Protein: MGRN1
E3 ubiquitin-protein ligase MGRN1 (EC 2.3.2.27) (Mahogunin RING finger protein 1) (RING finger protein 156) (RING-type E3 ubiquitin transferase MGRN1)

Gene: MGRN1
Organism: Homo sapiens
Interactions: 90
UniProt ID: O60291

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

244450

UB2D1
Ubiquitin-conjugating enzyme E2 D1

2

6

Small-scale

0.800

High

244493

TS101
Tumor susceptibility gene 101 protein

5

1

Small-scale

0.729

High

244451

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

6

High-throughput

0.698

High

244454

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

7

High-throughput

0.698

High

244455

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

6

High-throughput

0.698

High

244456

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

6

High-throughput

0.698

High

244457

UBC9
SUMO-conjugating enzyme UBC9

1

7

High-throughput

0.698

High

244489

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

9

High-throughput

0.698

High

244500

UBE2T
Ubiquitin-conjugating enzyme E2 T

1

7

High-throughput

0.698

High

244512

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

6

High-throughput

0.698

High

244478

ANR46
Ankyrin repeat domain-containing protein 46

4

1

High-throughput

0.697

High

244472

BTNL8
Butyrophilin-like protein 8

3

1

High-throughput

0.667

High

244431

ATRN
Attractin

3

4

High-throughput

0.662

High

244476

MEGF8
Multiple epidermal growth factor-like domains protein 8

3

4

High-throughput

0.662

High

244460

MSHR
Melanocyte-stimulating hormone receptor

3

2

Small-scale

0.640

High

244464

PDCD2
Programmed cell death protein 2

3

0

High-throughput

0.634

High

244508

AMFR
E3 ubiquitin-protein ligase AMFR

2

2

Small-scale

0.624

High

244482

UB2J2
Ubiquitin-conjugating enzyme E2 J2

1

9

High-throughput

0.621

High

244511

PSG8
Pregnancy-specific beta-1-glycoprotein 8

3

2

High-throughput

0.604

High

244505

INT7
Integrator complex subunit 7

2

0

High-throughput

0.602

High

244507

FBX2
F-box only protein 2

2

2

High-throughput

0.601

High

244463

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

2

0

High-throughput

0.585

High

244510

AT1B4
Protein ATP1B4

2

0

High-throughput

0.585

High

244435

LEG1
Galectin-1

2

0

High-throughput

0.576

High

244485

UB2Q2
Ubiquitin-conjugating enzyme E2 Q2

1

0

High-throughput

0.560

High

244465

PSG3
Pregnancy-specific beta-1-glycoprotein 3

2

2

High-throughput

0.549

High

244429

NMT2
Glycylpeptide N-tetradecanoyltransferase 2

1

1

High-throughput

0.536

High

244434

PPB1
Alkaline phosphatase, placental type

1

1

High-throughput

0.536

High

244436

PPBN
Alkaline phosphatase, germ cell type

1

1

High-throughput

0.536

High

244442

CALX
Calnexin

1

1

High-throughput

0.536

High

244443

NMT1
Glycylpeptide N-tetradecanoyltransferase 1

1

1

High-throughput

0.536

High

244470

HSDL1
Inactive hydroxysteroid dehydrogenase-like protein 1

1

1

High-throughput

0.536

High

244506

BTNL2
Butyrophilin-like protein 2

1

1

High-throughput

0.536

High

244477

TRI74
Tripartite motif-containing protein 74

1

0

High-throughput

0.518

High

144071

WNT7A
Protein Wnt-7a

1

0

High-throughput

0.513

High

244432

LY6H
Lymphocyte antigen 6H

1

0

High-throughput

0.513

High

244433

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

0

High-throughput

0.513

High

244440

ASM
Sphingomyelin phosphodiesterase

1

0

High-throughput

0.513

High

244441

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

0

High-throughput

0.513

High

244453

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

0

High-throughput

0.513

High

244462

PTC1
Protein patched homolog 1

1

0

High-throughput

0.513

High

244486

CANT1
Soluble calcium-activated nucleotidase 1

1

0

High-throughput

0.513

High

244488

T106A
Transmembrane protein 106A

1

0

High-throughput

0.513

High

244495

SIRPD
Signal-regulatory protein delta

1

0

High-throughput

0.513

High

244498

PGES2
Prostaglandin E synthase 2

1

0

High-throughput

0.513

High

244499

SDF2L
Stromal cell-derived factor 2-like protein 1

1

0

High-throughput

0.513

High

244514

AP1M2
AP-1 complex subunit mu-2

1

0

High-throughput

0.513

High

244502

TMPS4
Transmembrane protease serine 4

1

0

High-throughput

0.493

High

244437

PSG1
Pregnancy-specific beta-1-glycoprotein 1

1

2

High-throughput

0.489

High

126926

APBB1
Amyloid beta precursor protein binding family B member 1

1

1

Small-scale

0.479

High

244444

ARRB2
Beta-arrestin-2

1

1

Small-scale

0.479

High

244445

MC4R
Melanocortin receptor 4

1

2

Small-scale

0.479

High

244448

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

1

Small-scale

0.479

High

244449

ARRB1
Beta-arrestin-1

1

1

Small-scale

0.479

High

244459

ACTHR
Adrenocorticotropic hormone receptor

1

2

Small-scale

0.479

High

244461

CUL3
Cullin-3

1

1

High-throughput

0.479

High

244479

MFN1
Mitofusin-1

1

1

Small-scale

0.479

High

244491

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

1

Small-scale

0.479

High

244501

FBX6
F-box only protein 6

1

2

High-throughput

0.479

High

217573

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

244430

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

244446

HSP74
Heat shock 70 kDa protein 4

1

0

Small-scale

0.458

High

244447

HD
Huntingtin

1

0

Small-scale

0.458

High

244452

ATX3
Ataxin-3

1

0

Small-scale

0.458

High

244458

TBA4A
Tubulin alpha-4A chain

1

0

Small-scale

0.458

High

244467

DUS6
Dual specificity protein phosphatase 6

1

0

High-throughput

0.458

High

244468

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

244474

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

244475

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

244480

CHERP
Calcium homeostasis endoplasmic reticulum protein

1

0

High-throughput

0.458

High

244484

MRAP
Melanocortin-2 receptor accessory protein

1

0

Small-scale

0.458

High

244497

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

170571

CLGN
Calmegin

1

1

High-throughput

0.445

High

244483

ZNT7
Zinc transporter 7

1

0

High-throughput

0.426

High

244496

CENPH
Centromere protein H

1

0

High-throughput

0.426

High

244509

YLAT1
Y+L amino acid transporter 1

1

0

High-throughput

0.426

High

244481

CI040
Uncharacterized protein C9orf40

2

0

High-throughput

0.328

High

244494

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

2

0

High-throughput

0.328

High

244466

TAZ
Tafazzin

2

0

High-throughput

0.318

High

244439

EDN3
Endothelin-3

2

0

High-throughput

0.313

High

244487

PATE1
Prostate and testis expressed protein 1

2

0

High-throughput

0.313

High

244438

PSPC
Surfactant protein C

1

0

High-throughput

0.279

Low

244471

GPAT2
Glycerol-3-phosphate acyltransferase 2, mitochondrial

1

0

High-throughput

0.279

Low

244473

IGFL3
Insulin growth factor-like family member 3

1

0

High-throughput

0.279

Low

244490

ESPB1
Epididymal sperm-binding protein 1

1

0

High-throughput

0.279

Low

244492

TAFA4
Chemokine-like protein TAFA-4

1

0

High-throughput

0.279

Low

244503

CBLN4
Cerebellin-4

1

0

High-throughput

0.279

Low

244504

UQCC1
Ubiquinol-cytochrome c reductase complex assembly factor 1

1

0

High-throughput

0.279

Low

244513

PRG3
Proteoglycan 3

1

0

High-throughput

0.279

Low

244469

DB109
Beta-defensin 109B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025