HitPredict

Interactor 1: O62609 (O62609)
Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
Gene: Med

Interactor 2: MAD (P42003)
Protein mothers against dpp
Gene: MAD

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.88 1.00 0.941

The method score is based on:

Property Details
Experiments 9502724, 16951053, 18588885, 23847101, 23935523, 9693372
Identification Methods pull down, affinity chromatography technology
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains MH1~MH1, MH2~MH2
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
and 21 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 771
Dm

1 455
+ Dm
+ Dm
+ Dm
+ Dm
+ Hs
+ Hs
+ Mm
+ Hs
+ Mm
+ Ce
+ Hs
+ Mm
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Ce

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024