Protein: GDF8
Growth/differentiation factor 8 (GDF-8) (Myostatin)

Gene: GDF8, MSTN
Organism: Homo sapiens
Interactions: 33
UniProt ID: O14793

Gene Ontology (top 5):
GO:0005102 - signaling receptor binding
GO:0005125 - cytokine activity
GO:0005615 - extracellular space
GO:0007179 - transforming growth factor beta receptor signaling pathway
GO:0007517 - muscle organ development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

164751

GDF8
Growth/differentiation factor 8

2

16

Small-scale

0.838

High

164764

AVR2B
Activin receptor type-2B

2

20

Small-scale

0.785

High

164754

FSTL3
Follistatin-related protein 3

1

9

Small-scale

0.724

High

164752

GDF11
Growth/differentiation factor 11

1

17

High-throughput

0.691

High

164766

PRTG
Protogenin

1

2

High-throughput

0.691

High

164776

GDF15
Growth/differentiation factor 15

1

16

High-throughput

0.691

High

164759

BMP1
Bone morphogenetic protein 1

3

11

Small-scale

0.643

High

164757

FURIN
Furin

2

3

Small-scale

0.552

High

164775

WFKN1
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1

1

13

Small-scale

0.536

High

164758

CO6A2

1

8

High-throughput

0.536

High

164762

PCSK6
Proprotein convertase subtilisin/kexin type 6

1

9

High-throughput

0.536

High

164765

GAS6
Growth arrest-specific protein 6

1

14

High-throughput

0.536

High

164767

METRL
Meteorin-like protein

1

1

High-throughput

0.536

High

164771

VWDE
von Willebrand factor D and EGF domain-containing protein

1

6

High-throughput

0.536

High

164773

PCSK9
Proprotein convertase subtilisin/kexin type 9

1

3

High-throughput

0.536

High

164782

JAG2
Protein jagged-2

1

5

High-throughput

0.536

High

164756

A4
Amyloid-beta precursor protein

1

18

High-throughput

0.501

High

164753

ATS2
A disintegrin and metalloproteinase with thrombospondin motifs 2

1

6

High-throughput

0.489

High

164755

OXSR1
Serine/threonine-protein kinase OSR1

1

2

High-throughput

0.489

High

164763

LAMB2
Laminin subunit beta-2

1

5

High-throughput

0.489

High

164769

PLGT2
Protein O-glucosyltransferase 2

1

1

High-throughput

0.489

High

164770

MEGF8
Multiple epidermal growth factor-like domains protein 8

1

9

High-throughput

0.489

High

164772

PGLT1
Protein O-glucosyltransferase 1

1

1

High-throughput

0.489

High

164774

APBP2
Amyloid protein-binding protein 2

1

1

High-throughput

0.489

High

164777

CELR1
Cadherin EGF LAG seven-pass G-type receptor 1

1

4

High-throughput

0.489

High

164779

KLH42
Kelch-like protein 42

1

1

High-throughput

0.489

High

164780

ADA21
Disintegrin and metalloproteinase domain-containing protein 21

1

4

High-throughput

0.489

High

164781

ATS7
A disintegrin and metalloproteinase with thrombospondin motifs 7

1

6

High-throughput

0.489

High

164760

PERF
Perforin-1

1

0

High-throughput

0.279

Low

164761

ZNF24
Zinc finger protein 24

1

0

High-throughput

0.279

Low

164768

UTP25
U3 small nucleolar RNA-associated protein 25 homolog

1

0

High-throughput

0.279

Low

164778

CHPF2
Chondroitin sulfate glucuronyltransferase

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025