HitPredict

Interactor 1: DOK2 (O70469)
Docking protein 2 (Dok-related protein) (Dok-R) (Downstream of tyrosine kinase 2) (IL-four receptor-interacting protein) (FRIP) (p56(dok-2))
Gene: DOK2

Interactor 2: SRC (P05480)
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Gene: SRC

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.690

Property	Details
Experiments	15831486
Identification Methods	pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Mm			1 535
+	Hs
		235040 DOK2_HUMAN (4-412): 4.96e-142: 412: 74.04		SRC_HUMAN (1-535): 0: 645: 98.69
+	Hs
		235037 DOK2_HUMAN (4-412): 4.96e-142: 412: 74.04		YES_HUMAN (1-535): 0: 609: 73.85
+	Hs
		235036 DOK2_HUMAN (4-412): 4.96e-142: 412: 74.04		FYN_HUMAN (1-535): 0: 595: 68.70
+	Mm
		250950 DOK2_MOUSE (1-412): 1.11e-159: 457: 100.00		LYN_MOUSE (1-530): 0: 533: 52.35
+	Hs
		523124 DOK1_HUMAN (6-394): 5.32e-111: 336: 34.11		SRC_HUMAN (1-535): 0: 645: 98.69
+	Mm
		250948 DOK2_MOUSE (1-412): 1.11e-159: 457: 100.00		ABL1_MOUSE (50-535): 9.8e-172: 516: 40.16
+	Hs
		235035 DOK2_HUMAN (4-412): 4.96e-142: 412: 74.04		LCK_HUMAN (27-533): 0: 559: 54.01
+	Hs
		433460 DOK1_HUMAN (6-394): 5.32e-111: 336: 34.11		YES_HUMAN (1-535): 0: 609: 73.85
+	Hs
		235031 DOK2_HUMAN (4-412): 4.96e-142: 412: 74.04		ABL1_HUMAN (50-535): 1.03e-171: 516: 40.16
+	Hs
		454844 DOK1_HUMAN (6-394): 5.32e-111: 336: 34.11		FGR_HUMAN (1-534): 0: 584: 65.36
+	Hs
		235051 DOK2_HUMAN (4-412): 4.96e-142: 412: 74.04		CSK_HUMAN (83-524): 2.29e-171: 493: 39.38
+	Hs
		442876 DOK1_HUMAN (6-394): 5.32e-111: 336: 34.11		HCK_HUMAN (1-530): 0: 566: 55.66
+	Hs
		235052 DOK2_HUMAN (4-412): 4.96e-142: 412: 74.04		TXK_HUMAN (11-525): 9.96e-163: 474: 34.29
+	Mm
		639441 DOK1_MOUSE (6-393): 3.94e-113: 341: 34.51		LYN_MOUSE (1-530): 0: 533: 52.35
+	Hs
		433966 DOK1_HUMAN (6-394): 5.32e-111: 336: 34.11		LYN_HUMAN (1-530): 0: 534: 52.92
+	Hs
		789086 DOK1_HUMAN (6-394): 5.32e-111: 336: 34.11		ABL2_HUMAN (2-535): 1.44e-174: 525: 38.46
+	Mm
		337623 DOK1_MOUSE (6-393): 3.94e-113: 341: 34.51		ABL1_MOUSE (50-535): 9.8e-172: 516: 40.16
+	Hs
		337542 DOK1_HUMAN (6-394): 5.32e-111: 336: 34.11		ABL1_HUMAN (50-535): 1.03e-171: 516: 40.16
+	Hs
		789005 DOK1_HUMAN (6-394): 5.32e-111: 336: 34.11		TEC_HUMAN (62-527): 2.74e-155: 459: 35.79
+	Mm
		623689 DOK1_MOUSE (6-393): 3.94e-113: 341: 34.51		TEC_MOUSE (87-527): 6.89e-152: 450: 38.22