Protein: XCT
Cystine/glutamate transporter (Amino acid transport system xc-) (Calcium channel blocker resistance protein CCBR1) (Solute carrier family 7 member 11) (xCT)

Gene: XCT, SLC7A11
Organism: Homo sapiens
Interactions: 218
UniProt ID: Q9UPY5

Gene Ontology (top 5):
GO:0003333 - amino acid transmembrane transport
GO:0005886 - plasma membrane
GO:0006749 - glutathione metabolic process
GO:0008542 - visual learning
GO:0009636 - response to toxic substance

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

467653

4F2
Amino acid transporter heavy chain SLC3A2

6

11

Small-scale

0.933

High

1452329

SCN3B
Sodium channel regulatory subunit beta-3

1

5

High-throughput

0.691

High

1462625

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

6

High-throughput

0.691

High

591396

CD44
CD44 antigen

3

0

Small-scale

0.619

High

845864

MUC18
Cell surface glycoprotein MUC18

1

5

High-throughput

0.618

High

710577

EPHA2
Ephrin type-A receptor 2

2

15

High-throughput

0.601

High

374286

RASN
GTPase NRas

2

20

High-throughput

0.584

High

375020

RASH
GTPase HRas

2

20

High-throughput

0.584

High

376104

RASK
GTPase KRas

2

20

High-throughput

0.584

High

1212630

HECD3
E3 ubiquitin-protein ligase HECTD3

2

5

Small-scale

0.558

High

1059761

KRA11
Keratin-associated protein 1-1

2

1

High-throughput

0.553

High

1307473

KRA13
Keratin-associated protein 1-3

2

1

High-throughput

0.553

High

1341200

PPTC7
Protein phosphatase PTC7 homolog

2

1

High-throughput

0.549

High

1351543

HAVR2
Hepatitis A virus cellular receptor 2

1

0

High-throughput

0.546

High

260989

RAMP3
Receptor activity-modifying protein 3

1

1

High-throughput

0.536

High

688690

NKG2C
NKG2-C type II integral membrane protein

1

11

High-throughput

0.536

High

1090119

KLRB1
Killer cell lectin-like receptor subfamily B member 1

1

9

High-throughput

0.536

High

1098952

KLRD1
Natural killer cells antigen CD94

1

9

High-throughput

0.536

High

1273300

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

4

High-throughput

0.536

High

1432204

ADAM7
Disintegrin and metalloproteinase domain-containing protein 7

1

4

High-throughput

0.536

High

1460031

CLC2D
C-type lectin domain family 2 member D

1

9

High-throughput

0.536

High

1461854

CLC4E
C-type lectin domain family 4 member E

1

4

High-throughput

0.536

High

1459334

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

Small-scale

0.528

High

749421

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

0

High-throughput

0.513

High

1034849

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.513

High

1096943

FADD
FAS-associated death domain protein

1

0

High-throughput

0.513

High

1159251

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.513

High

1295049

TMM25
Transmembrane protein 25

1

0

High-throughput

0.513

High

1359103

ITLN1
Intelectin-1

1

0

High-throughput

0.513

High

724713

MK04
Mitogen-activated protein kinase 4

1

2

High-throughput

0.489

High

1239342

ARMC6
Armadillo repeat-containing protein 6

1

2

High-throughput

0.489

High

1310202

SFPA2
Pulmonary surfactant-associated protein A2

1

4

High-throughput

0.489

High

126877

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

218968

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

364036

EGFR
Epidermal growth factor receptor

1

15

Small-scale

0.479

High

463846

LYN
Tyrosine-protein kinase Lyn

1

9

High-throughput

0.479

High

466530

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

540756

LAMP1
Lysosome-associated membrane glycoprotein 1

1

11

High-throughput

0.479

High

581376

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

601503

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

715848

MARCS
Myristoylated alanine-rich C-kinase substrate

1

4

High-throughput

0.479

High

910257

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

953763

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

955762

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

962642

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

962862

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

975326

ARF6
ADP-ribosylation factor 6

1

7

High-throughput

0.479

High

978410

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

988833

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

1015910

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

1041374

CAV1
Caveolin-1

1

4

High-throughput

0.479

High

1151934

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

1271056

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

1287473

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

10

Small-scale

0.479

High

1366917

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

1396660

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.479

High

1433584

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

1438248

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

162982

TERT
Telomerase reverse transcriptase

1

0

Small-scale

0.460

High

173566

XPO1
Exportin-1

1

1

High-throughput

0.445

High

250950

TPST1
Protein-tyrosine sulfotransferase 1

1

6

High-throughput

0.445

High

573723

ENPL
Endoplasmin

1

10

High-throughput

0.445

High

606055

CAN2
Calpain-2 catalytic subunit

1

1

High-throughput

0.445

High

719761

HLAF
HLA class I histocompatibility antigen, alpha chain F

1

1

High-throughput

0.445

High

755647

TTK
Dual specificity protein kinase TTK

1

6

High-throughput

0.445

High

837268

ACTY
Beta-centractin

1

2

High-throughput

0.445

High

839405

MTOR
Serine/threonine-protein kinase mTOR

1

7

High-throughput

0.445

High

839519

PI4KA
Phosphatidylinositol 4-kinase alpha

1

3

High-throughput

0.445

High

938635

PSA
Puromycin-sensitive aminopeptidase

1

2

High-throughput

0.445

High

945878

EPIPL
Epiplakin

1

1

High-throughput

0.445

High

983616

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

1

High-throughput

0.445

High

1105836

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

1

4

High-throughput

0.445

High

1204823

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

1

High-throughput

0.445

High

1217227

RIF1
Telomere-associated protein RIF1

1

2

High-throughput

0.445

High

1224789

RN213
E3 ubiquitin-protein ligase RNF213

1

1

High-throughput

0.445

High

1294522

VRK2
Serine/threonine-protein kinase VRK2

1

3

High-throughput

0.445

High

1312305

MIRO2
Mitochondrial Rho GTPase 2

1

20

High-throughput

0.445

High

1316786

WDFY3
WD repeat and FYVE domain-containing protein 3

1

6

High-throughput

0.445

High

1323860

INT1
Integrator complex subunit 1

1

1

High-throughput

0.445

High

1339474

TOIP2
Torsin-1A-interacting protein 2

1

1

High-throughput

0.445

High

1364072

NICA
Nicastrin

1

1

High-throughput

0.445

High

1365793

GCN1
Stalled ribosome sensor GCN1

1

2

High-throughput

0.445

High

1382608

EXOC4
Exocyst complex component 4

1

1

High-throughput

0.445

High

1386802

GCP3
Gamma-tubulin complex component 3

1

4

High-throughput

0.445

High

1410686

APOL2
Apolipoprotein L2

1

1

High-throughput

0.445

High

1410978

CSTN3
Calsyntenin-3

1

2

High-throughput

0.445

High

1411657

ADPGK
ADP-dependent glucokinase

1

3

High-throughput

0.445

High

1412558

GCP2
Gamma-tubulin complex component 2

1

4

High-throughput

0.445

High

1415053

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

1

2

High-throughput

0.445

High

1417522

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.445

High

1420155

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

2

High-throughput

0.445

High

1449716

MDN1
Midasin

1

1

High-throughput

0.445

High

1454420

STK26
Serine/threonine-protein kinase 26

1

3

High-throughput

0.445

High

1459562

GCP4
Gamma-tubulin complex component 4

1

4

High-throughput

0.445

High

1459958

DDX20
Probable ATP-dependent RNA helicase DDX20

1

2

High-throughput

0.445

High

1460355

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

2

High-throughput

0.445

High

1460469

LCAP
Leucyl-cystinyl aminopeptidase

1

2

High-throughput

0.445

High

1461261

AMFR
E3 ubiquitin-protein ligase AMFR

1

7

High-throughput

0.445

High

125664

LEG9
Galectin-9

1

13

High-throughput

0.437

High

155137

SOCS2
Suppressor of cytokine signaling 2

1

9

Small-scale

0.437

High

227710

SPOP
Speckle-type POZ protein

1

1

High-throughput

0.437

High

639330

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

3

Small-scale

0.437

High

956543

RAB2A
Ras-related protein Rab-2A

1

13

High-throughput

0.437

High

957693

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

1

Small-scale

0.437

High

1005251

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.437

High

1293210

TMM17
Transmembrane protein 17

1

4

High-throughput

0.437

High

245559

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

0

High-throughput

0.426

High

292779

RENR
Renin receptor

1

0

High-throughput

0.426

High

608206

PYRG1
CTP synthase 1

1

0

High-throughput

0.426

High

637980

NF1
Neurofibromin

1

0

High-throughput

0.426

High

870179

LIMS1
LIM and senescent cell antigen-like-containing domain protein 1

1

0

High-throughput

0.426

High

897621

KNTC1
Kinetochore-associated protein 1

1

0

High-throughput

0.426

High

921833

COPB
Coatomer subunit beta

1

0

High-throughput

0.426

High

944596

GEMI4
Gem-associated protein 4

1

0

High-throughput

0.426

High

945332

NU107
Nuclear pore complex protein Nup107

1

0

High-throughput

0.426

High

1131430

GANAB
Neutral alpha-glucosidase AB

1

0

High-throughput

0.426

High

1156718

NF2L2
Nuclear factor erythroid 2-related factor 2

1

0

High-throughput

0.426

High

1210135

SNP47
Synaptosomal-associated protein 47

1

0

High-throughput

0.426

High

1245234

BRAT1
Integrator complex assembly factor BRAT1

1

0

High-throughput

0.426

High

1293752

CNDG2
Condensin-2 complex subunit G2

1

0

High-throughput

0.426

High

1315154

EXOC8
Exocyst complex component 8

1

0

High-throughput

0.426

High

1347260

EXOC6
Exocyst complex component 6

1

0

High-throughput

0.426

High

1356281

ABHD3
Phospholipase ABHD3

1

0

High-throughput

0.426

High

1356955

NU133
Nuclear pore complex protein Nup133

1

0

High-throughput

0.426

High

1365926

NU205
Nuclear pore complex protein Nup205

1

0

High-throughput

0.426

High

1387081

COQ8B
Atypical kinase COQ8B, mitochondrial

1

0

High-throughput

0.426

High

1403617

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.426

High

1430051

INT2
Integrator complex subunit 2

1

0

High-throughput

0.426

High

1434537

HEAT1
HEAT repeat-containing protein 1

1

0

High-throughput

0.426

High

1462628

C2CD2
C2 domain-containing protein 2

1

0

High-throughput

0.426

High

1462629

LAS1L
Ribosomal biogenesis protein LAS1L

1

0

High-throughput

0.426

High

1462631

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

0

High-throughput

0.426

High

73869

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

1

High-throughput

0.407

High

161846

RIOK3
Serine/threonine-protein kinase RIO3

1

1

High-throughput

0.407

High

177341

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

4

High-throughput

0.407

High

187575

FANCA
Fanconi anemia group A protein

1

2

High-throughput

0.407

High

273240

CAND2
Cullin-associated NEDD8-dissociated protein 2

1

2

High-throughput

0.407

High

295553

PSD10
26S proteasome non-ATPase regulatory subunit 10

1

3

High-throughput

0.407

High

317384

ACL6B
Actin-like protein 6B

1

1

High-throughput

0.407

High

585830

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

1

3

High-throughput

0.407

High

853140

ACDSB
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial

1

3

High-throughput

0.407

High

906249

SSDH
Succinate-semialdehyde dehydrogenase, mitochondrial

1

1

High-throughput

0.407

High

958540

ACTZ
Alpha-centractin

1

2

High-throughput

0.407

High

977611

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

1

High-throughput

0.407

High

997187

TBA4A
Tubulin alpha-4A chain

1

2

High-throughput

0.407

High

1052384

RN5A
2-5A-dependent ribonuclease

1

6

High-throughput

0.407

High

1102294

ATM
Serine-protein kinase ATM

1

3

High-throughput

0.407

High

1129584

ESPL1
Separin

1

1

High-throughput

0.407

High

1135949

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

1

High-throughput

0.407

High

1200293

FAKD1
FAST kinase domain-containing protein 1, mitochondrial

1

1

High-throughput

0.407

High

1210639

SYVM
Valine--tRNA ligase, mitochondrial

1

1

High-throughput

0.407

High

1235750

SCMC2
Mitochondrial adenyl nucleotide antiporter SLC25A25

1

1

High-throughput

0.407

High

1242105

TTC27
Tetratricopeptide repeat protein 27

1

3

High-throughput

0.407

High

1244389

SKI3
Superkiller complex protein 3

1

2

High-throughput

0.407

High

1257965

UBP34
Ubiquitin carboxyl-terminal hydrolase 34

1

2

High-throughput

0.407

High

1277541

MON2
Protein MON2 homolog

1

5

High-throughput

0.407

High

1333095

ANR52
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

1

4

High-throughput

0.407

High

1350920

HUMMR
Protein MGARP

1

1

High-throughput

0.407

High

1351322

DMXL2
DmX-like protein 2

1

2

High-throughput

0.407

High

1385179

ATG2B
Autophagy-related protein 2 homolog B

1

1

High-throughput

0.407

High

1388883

HOOK2
Protein Hook homolog 2

1

2

High-throughput

0.407

High

1395520

CLMN
Calmin

1

1

High-throughput

0.407

High

1415983

IFT27
Intraflagellar transport protein 27 homolog

1

14

High-throughput

0.407

High

1416041

SYTM
Threonine--tRNA ligase, mitochondrial

1

1

High-throughput

0.407

High

1449379

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

1

High-throughput

0.407

High

1462627

DOP1B
Protein DOP1B

1

2

High-throughput

0.407

High

1462630

BIG1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1

1

5

High-throughput

0.407

High

1391078

OTUB1
Ubiquitin thioesterase OTUB1

5

0

Small-scale

0.371

High

1326677

IT70B
Intraflagellar transport protein 70B

2

0

High-throughput

0.313

High

337200

APOM
Apolipoprotein M

1

0

High-throughput

0.279

Low

1090979

TRAF2
TNF receptor-associated factor 2

1

0

High-throughput

0.279

Low

1460251

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.279

Low

1089287

TRI26
Tripartite motif-containing protein 26

1

0

Small-scale

0.249

Low

1383281

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.249

Low

1413002

CNPY3
Protein canopy homolog 3

1

0

Small-scale

0.249

Low

128492

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

0

High-throughput

0.232

Low

137294

EXOC5
Exocyst complex component 5

1

0

High-throughput

0.232

Low

173767

BTAF1
TATA-binding protein-associated factor 172

1

0

High-throughput

0.232

Low

275791

NDUS2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

1

0

High-throughput

0.232

Low

302997

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

0

High-throughput

0.232

Low

327667

ELP1
Elongator complex protein 1

1

0

High-throughput

0.232

Low

335650

AGM1
Phosphoacetylglucosamine mutase

1

0

High-throughput

0.232

Low

405359

OAT
Ornithine aminotransferase, mitochondrial

1

0

High-throughput

0.232

Low

539102

UMPS
Uridine 5'-monophosphate synthase

1

0

High-throughput

0.232

Low

611700

ERCC2
General transcription and DNA repair factor IIH helicase subunit XPD

1

0

High-throughput

0.232

Low

722765

AL1B1
Aldehyde dehydrogenase X, mitochondrial

1

0

High-throughput

0.232

Low

884857

PPM1F
Protein phosphatase 1F

1

0

High-throughput

0.232

Low

1092725

AF1Q
Protein AF1q

1

0

High-throughput

0.232

Low

1131911

COG2
Conserved oligomeric Golgi complex subunit 2

1

0

High-throughput

0.232

Low

1149480

SKI2
Superkiller complex protein 2

1

0

High-throughput

0.232

Low

1160620

SMN
Survival motor neuron protein

1

0

High-throughput

0.232

Low

1206259

PREP
Presequence protease, mitochondrial

1

0

High-throughput

0.232

Low

1215387

DCAF8
DDB1- and CUL4-associated factor 8

1

0

High-throughput

0.232

Low

1243258

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

1

0

High-throughput

0.232

Low

1251572

THADA
tRNA

1

0

High-throughput

0.232

Low

1307367

ZNG1B
Zinc-regulated GTPase metalloprotein activator 1B

1

0

High-throughput

0.232

Low

1325289

VPS8
Vacuolar protein sorting-associated protein 8 homolog

1

0

High-throughput

0.232

Low

1333213

AFG2A
ATPase family gene 2 protein homolog A

1

0

High-throughput

0.232

Low

1336984

SIMC1
SUMO-interacting motif-containing protein 1

1

0

High-throughput

0.232

Low

1339042

NUP43
Nucleoporin Nup43

1

0

High-throughput

0.232

Low

1359277

CA054
Uncharacterized protein C1orf54

1

0

High-throughput

0.232

Low

1360359

ATRIP
ATR-interacting protein

1

0

High-throughput

0.232

Low

1385769

INT12
Integrator complex subunit 12

1

0

High-throughput

0.232

Low

1389626

SAAL1
Protein SAAL1

1

0

High-throughput

0.232

Low

1398256

H6ST2
Heparan-sulfate 6-O-sulfotransferase 2

1

0

High-throughput

0.232

Low

1413836

HGH1
Protein HGH1 homolog

1

0

High-throughput

0.232

Low

1436080

GEMI7
Gem-associated protein 7

1

0

High-throughput

0.232

Low

1437041

COG4
Conserved oligomeric Golgi complex subunit 4

1

0

High-throughput

0.232

Low

1446377

INO1
Inositol-3-phosphate synthase 1

1

0

High-throughput

0.232

Low

1446725

TMM9B
Transmembrane protein 9B

1

0

High-throughput

0.232

Low

1449394

FIRRM
FIGNL1-interacting regulator of recombination and mitosis

1

0

High-throughput

0.232

Low

1449560

SMC4
Structural maintenance of chromosomes protein 4

1

0

High-throughput

0.232

Low

1450420

PANK4
4'-phosphopantetheine phosphatase

1

0

High-throughput

0.232

Low

1451591

GEMI8
Gem-associated protein 8

1

0

High-throughput

0.232

Low

1451976

NSMA3
Sphingomyelin phosphodiesterase 4

1

0

High-throughput

0.232

Low

1452021

P4HTM
Transmembrane prolyl 4-hydroxylase

1

0

High-throughput

0.232

Low

1460104

GPN3
GPN-loop GTPase 3

1

0

High-throughput

0.232

Low

1462626

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025