HitPredict

Interactor 1: RAD1 (O60671)
Cell cycle checkpoint protein RAD1 (hRAD1) (Rad1-like DNA damage checkpoint protein)
Gene: RAD1

Interactor 2: RAD17 (O75943)
Cell cycle checkpoint protein RAD17 (hRad17) (RF-C/activator 1 homolog)
Gene: RAD17

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.746

Property	Details
Experiments	11418864, 33961781, 27387238, 19535328, 12578958, 10884395, 31353086
Identification Methods	affinity chromatography technology, pull down, biochemical, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000077 - DNA damage checkpoint signaling GO:0005654 - nucleoplasm GO:0006281 - DNA repair GO:0006974 - DNA damage response
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 282 Hs			1 681
+	Hs
		253188 RAD1_HUMAN (1-282): 2.17e-126: 362: 100.00		RFC4_HUMAN (58-407): 5.91e-75: 247: 15.45
+	Hs
		253191 RAD1_HUMAN (1-282): 2.17e-126: 362: 100.00		RFC5_HUMAN (64-433): 6.07e-74: 243: 15.95
+	Hs
		253192 RAD1_HUMAN (1-282): 2.17e-126: 362: 100.00		RFC3_HUMAN (90-460): 9.08e-64: 217: 12.77
+	Sp
		645670 RAD1_SCHPO (24-277): 3.8e-89: 269: 28.36		RAD17_SCHPO (42-529): 5.46e-76: 257: 23.61
+	Sc
		744208 RAD17_YEAST (21-261): 3.63e-71: 226: 16.92		RAD24_YEAST (38-482): 3.96e-65: 229: 23.40