Protein: RFC5
Replication factor C subunit 5 (Activator 1 36 kDa subunit) (A1 36 kDa subunit) (Activator 1 subunit 5) (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36)

Gene: RFC5
Organism: Homo sapiens
Interactions: 203
UniProt ID: P40937

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005663 - DNA replication factor C complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

769669

RFC4
Replication factor C subunit 4

17

16

Small-scale

0.987

High

769818

RFC2
Replication factor C subunit 2

9

17

Small-scale

0.965

High

298580

RAD17
Cell cycle checkpoint protein RAD17

6

20

Small-scale

0.948

High

829130

ATAD5
ATPase family AAA domain-containing protein 5

5

20

Small-scale

0.919

High

829123

CTF18
Chromosome transmission fidelity protein 18 homolog

4

17

Small-scale

0.906

High

259564

BRD4
Bromodomain-containing protein 4

4

13

Small-scale

0.902

High

829043

RFC3
Replication factor C subunit 3

4

16

High-throughput

0.892

High

769933

RFC1
Replication factor C subunit 1

4

20

Small-scale

0.887

High

550903

PCNA
Proliferating cell nuclear antigen

4

12

Small-scale

0.882

High

829136

RAD9A
Cell cycle checkpoint control protein RAD9A

3

3

Small-scale

0.839

High

240968

PRKN
E3 ubiquitin-protein ligase parkin

2

5

High-throughput

0.754

High

829064

XIAP
E3 ubiquitin-protein ligase XIAP

5

6

High-throughput

0.722

High

829089

NAB2
NGFI-A-binding protein 2

5

0

High-throughput

0.691

High

829140

DCC1
Sister chromatid cohesion protein DCC1

4

7

High-throughput

0.691

High

694811

RFA1
Replication protein A 70 kDa DNA-binding subunit

4

3

Small-scale

0.686

High

506694

CTF8
Chromosome transmission fidelity protein 8 homolog

3

2

High-throughput

0.662

High

767588

RFA3
Replication protein A 14 kDa subunit

3

3

High-throughput

0.656

High

588096

RFA2
Replication protein A 32 kDa subunit

3

5

High-throughput

0.640

High

253191

RAD1
Cell cycle checkpoint protein RAD1

1

2

Small-scale

0.618

High

507636

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

High-throughput

0.618

High

674100

BRD2
Bromodomain-containing protein 2

1

16

High-throughput

0.618

High

829052

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.618

High

829086

BRD3
Bromodomain-containing protein 3

1

13

High-throughput

0.618

High

261706

HUS1
Checkpoint protein HUS1

2

2

Small-scale

0.611

High

371367

MYC
Myc proto-oncogene protein

2

3

High-throughput

0.611

High

487042

PARP1
Poly [ADP-ribose] polymerase 1

2

11

High-throughput

0.611

High

829076

CUL3
Cullin-3

2

5

High-throughput

0.611

High

829067

ARI5A
AT-rich interactive domain-containing protein 5A

2

1

High-throughput

0.606

High

829070

STF1
Steroidogenic factor 1

2

5

High-throughput

0.606

High

829074

BIRC2
Baculoviral IAP repeat-containing protein 2

2

7

High-throughput

0.606

High

829100

TASO2
Protein TASOR 2

2

4

High-throughput

0.606

High

829132

PP16B
Protein phosphatase 1 regulatory inhibitor subunit 16B

2

3

High-throughput

0.606

High

442625

RB
Retinoblastoma-associated protein

2

0

High-throughput

0.602

High

128824

MEN1
Menin

2

3

High-throughput

0.584

High

829059

H4
Histone H4

2

7

High-throughput

0.584

High

829062

H31
Histone H3.1

2

13

High-throughput

0.584

High

829155

ECT2
Protein ECT2

2

3

High-throughput

0.584

High

829163

ANLN
Anillin

2

3

High-throughput

0.584

High

829166

MCM9
DNA helicase MCM9

2

5

Small-scale

0.584

High

829169

ZRAN1
Ubiquitin thioesterase ZRANB1

2

4

High-throughput

0.584

High

600055

ZNF19
Zinc finger protein 19

2

0

High-throughput

0.580

High

666806

CCNC
Cyclin-C

2

0

High-throughput

0.580

High

829102

XAF1
XIAP-associated factor 1

2

0

High-throughput

0.580

High

829121

LMO3
LIM domain only protein 3

2

0

High-throughput

0.580

High

829126

EXOS8
Exosome complex component RRP43

2

0

High-throughput

0.580

High

829135

TSNAX
Translin-associated protein X

2

0

High-throughput

0.580

High

829139

ZN426
Zinc finger protein 426

2

0

High-throughput

0.580

High

395630

ESR1
Estrogen receptor

2

6

High-throughput

0.571

High

175967

N4BP3
NEDD4-binding protein 3

2

1

High-throughput

0.553

High

829061

EF1A1
Elongation factor 1-alpha 1

1

1

High-throughput

0.541

High

829051

DAPK1
Death-associated protein kinase 1

1

2

High-throughput

0.536

High

140789

NOP56
Nucleolar protein 56

1

3

High-throughput

0.536

High

446725

NPM
Nucleophosmin

1

3

High-throughput

0.536

High

501927

H2AZ
Histone H2A.Z

1

5

High-throughput

0.536

High

541871

TOP1
DNA topoisomerase 1

1

2

High-throughput

0.536

High

563360

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.536

High

601585

HMGA1
High mobility group protein HMG-I/HMG-Y

1

1

High-throughput

0.536

High

693574

RL10
Large ribosomal subunit protein uL16

1

3

High-throughput

0.536

High

829050

HDGF
Hepatoma-derived growth factor

1

3

High-throughput

0.536

High

829060

RACK1
Small ribosomal subunit protein RACK1

1

3

High-throughput

0.536

High

829065

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

3

High-throughput

0.536

High

829068

SSRP1
FACT complex subunit SSRP1

1

8

High-throughput

0.536

High

829083

NUMA1
Nuclear mitotic apparatus protein 1

1

2

High-throughput

0.536

High

829091

H2B2E
Histone H2B type 2-E

1

14

High-throughput

0.536

High

829111

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

2

High-throughput

0.536

High

829112

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.536

High

829143

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.536

High

829178

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

2

High-throughput

0.536

High

829093

RBM48
RNA-binding protein 48

1

0

High-throughput

0.518

High

829108

CSN6
COP9 signalosome complex subunit 6

1

0

High-throughput

0.518

High

829175

MED31
Mediator of RNA polymerase II transcription subunit 31

1

0

High-throughput

0.518

High

829137

AKAP9
A-kinase anchor protein 9

1

5

High-throughput

0.515

High

829077

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.513

High

829147

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

0

High-throughput

0.513

High

829174

DRG1
Developmentally-regulated GTP-binding protein 1

1

0

High-throughput

0.513

High

829055

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

High-throughput

0.501

High

829057

SUMO2
Small ubiquitin-related modifier 2

1

3

High-throughput

0.501

High

683208

TNR5
Tumor necrosis factor receptor superfamily member 5

1

0

High-throughput

0.493

High

829149

GO45
Golgin-45

1

0

High-throughput

0.493

High

829157

EAF6
Chromatin modification-related protein MEAF6

1

0

High-throughput

0.493

High

488298

PPBI
Intestinal-type alkaline phosphatase

1

1

High-throughput

0.489

High

829080

I13R2
Interleukin-13 receptor subunit alpha-2

1

2

High-throughput

0.489

High

829144

DNAI2
Dynein axonemal intermediate chain 2

1

2

High-throughput

0.489

High

829170

SRP68
Signal recognition particle subunit SRP68

1

1

High-throughput

0.489

High

131785

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

6

High-throughput

0.479

High

157044

CTRO
Citron Rho-interacting kinase

1

4

High-throughput

0.479

High

190841

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

4

High-throughput

0.479

High

247718

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

285127

EED
Polycomb protein EED

1

4

High-throughput

0.479

High

293322

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.479

High

302415

RNF8
E3 ubiquitin-protein ligase RNF8

1

3

High-throughput

0.479

High

315227

RECQ4
ATP-dependent DNA helicase Q4

1

5

High-throughput

0.479

High

319483

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

324615

HEXI1
Protein HEXIM1

1

2

High-throughput

0.479

High

340842

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

6

High-throughput

0.479

High

362906

EGFR
Epidermal growth factor receptor

1

7

High-throughput

0.479

High

411508

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

418870

H2A1B
Histone H2A type 1-B/E

1

7

High-throughput

0.479

High

472499

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

3

High-throughput

0.479

High

629619

BTF3
Transcription factor BTF3

1

2

High-throughput

0.479

High

664661

CCND1
G1/S-specific cyclin-D1

1

2

High-throughput

0.479

High

754749

H2B1B
Histone H2B type 1-B

1

14

High-throughput

0.479

High

766266

PHB1
Prohibitin 1

1

2

High-throughput

0.479

High

829044

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

829045

NKX21
Homeobox protein Nkx-2.1

1

4

High-throughput

0.479

High

829046

SOX2
Transcription factor SOX-2

1

11

High-throughput

0.479

High

829047

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

4

High-throughput

0.479

High

829048

CENPA
Histone H3-like centromeric protein A

1

13

High-throughput

0.479

High

829053

FOXA1
Hepatocyte nuclear factor 3-alpha

1

1

High-throughput

0.479

High

829058

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

829063

H33
Histone H3.3

1

13

High-throughput

0.479

High

829066

KIF23
Kinesin-like protein KIF23

1

2

High-throughput

0.479

High

829069

TIF1B
Transcription intermediary factor 1-beta

1

5

High-throughput

0.479

High

829072

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

6

High-throughput

0.479

High

829073

BIRC3
Baculoviral IAP repeat-containing protein 3

1

6

High-throughput

0.479

High

829075

SNW1
SNW domain-containing protein 1

1

3

High-throughput

0.479

High

829079

HLTF
Helicase-like transcription factor

1

7

High-throughput

0.479

High

829081

MDC1
Mediator of DNA damage checkpoint protein 1

1

6

High-throughput

0.479

High

829084

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

829085

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

829087

PCBP1
Poly(rC)-binding protein 1

1

2

High-throughput

0.479

High

829088

T22D1
TSC22 domain family protein 1

1

3

High-throughput

0.479

High

829090

HIF1A
Hypoxia-inducible factor 1-alpha

1

4

High-throughput

0.479

High

829099

MYSM1
Deubiquitinase MYSM1

1

3

Small-scale

0.479

High

829103

ZN746
Zinc finger protein 746

1

1

High-throughput

0.479

High

829107

MEPCE
7SK snRNA methylphosphate capping enzyme

1

2

High-throughput

0.479

High

829109

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

829110

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

6

High-throughput

0.479

High

829116

ZBT38
Zinc finger and BTB domain-containing protein 38

1

2

Small-scale

0.479

High

829120

COP1
E3 ubiquitin-protein ligase COP1

1

1

High-throughput

0.479

High

829122

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

3

High-throughput

0.479

High

829124

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

3

Small-scale

0.479

High

829125

ESR2
Estrogen receptor beta

1

6

High-throughput

0.479

High

829129

CI072
Guanine nucleotide exchange factor C9orf72

1

4

High-throughput

0.479

High

829131

CIC
Protein capicua homolog

1

9

High-throughput

0.479

High

829134

CDC5L
Cell division cycle 5-like protein

1

3

High-throughput

0.479

High

829138

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

5

High-throughput

0.479

High

829141

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

4

Small-scale

0.479

High

829142

FACD2
Fanconi anemia group D2 protein

1

7

High-throughput

0.479

High

829145

SPRTN
DNA-dependent metalloprotease SPRTN

1

3

High-throughput

0.479

High

829146

CCDC8
Coiled-coil domain-containing protein 8

1

2

High-throughput

0.479

High

829150

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

2

High-throughput

0.479

High

829151

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

5

High-throughput

0.479

High

829158

PIDD1
p53-induced death domain-containing protein 1

1

1

Small-scale

0.479

High

829159

RC3H2
Roquin-2

1

5

High-throughput

0.479

High

829162

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

829164

FBX6
F-box only protein 6

1

1

High-throughput

0.479

High

829167

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

829168

PD1L1
Programmed cell death 1 ligand 1

1

1

Small-scale

0.479

High

829172

FZR1
Fizzy-related protein homolog

1

4

High-throughput

0.479

High

829173

RUVB2
RuvB-like 2

1

11

High-throughput

0.479

High

829176

ZN330
Zinc finger protein 330

1

1

High-throughput

0.479

High

829177

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.479

High

829179

MAFB
Transcription factor MafB

1

7

High-throughput

0.479

High

2930

A0A0C4DGQ7
EMAP like 2

1

2

High-throughput

0.470

High

829092

ZMAT1
Zinc finger matrin-type protein 1

1

0

High-throughput

0.460

High

829094

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.460

High

222786

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

289944

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

799780

COIL
Coilin

1

0

High-throughput

0.458

High

829114

NIN
Ninein

1

0

High-throughput

0.458

High

829118

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

829133

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

829154

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

829160

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.458

High

829165

MKS1
Tectonic-like complex member MKS1

1

0

High-throughput

0.458

High

829098

RIF1
Telomere-associated protein RIF1

1

3

High-throughput

0.457

High

273409

KDM4A
Lysine-specific demethylase 4A

1

6

Small-scale

0.445

High

429449

JUN
Transcription factor Jun

1

5

High-throughput

0.445

High

829054

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

2

High-throughput

0.445

High

829082

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

2

High-throughput

0.445

High

829156

LN28A
Protein lin-28 homolog A

1

2

High-throughput

0.445

High

348899

EMAL2
Echinoderm microtubule-associated protein-like 2

1

1

High-throughput

0.439

High

829078

TRI29
Tripartite motif-containing protein 29

1

4

Small-scale

0.437

High

829096

RC3H1
Roquin-1

1

2

High-throughput

0.437

High

829101

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.437

High

829106

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

829115

FBXL6
F-box/LRR-repeat protein 6

1

2

High-throughput

0.437

High

829128

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.437

High

829148

ATG5
Autophagy protein 5

1

1

High-throughput

0.437

High

829152

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

829153

RPAP3
RNA polymerase II-associated protein 3

1

1

High-throughput

0.437

High

829161

CPAP
Centrosomal P4.1-associated protein

1

1

High-throughput

0.437

High

829171

HECD1
E3 ubiquitin-protein ligase HECTD1

1

7

High-throughput

0.437

High

829049

CEBPA
CCAAT/enhancer-binding protein alpha

1

8

High-throughput

0.408

High

957

SIM26
Small integral membrane protein 26

1

2

High-throughput

0.407

High

327844

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

2

High-throughput

0.407

High

829095

LITD1
LINE-1 type transposase domain-containing protein 1

1

1

High-throughput

0.407

High

829104

NBEL2
Neurobeachin-like protein 2

1

2

High-throughput

0.407

High

142668

TRI38
E3 ubiquitin-protein ligase TRIM38

5

0

High-throughput

0.376

High

70917

CMI2B
Ciliary microtubule inner protein 2B

2

0

High-throughput

0.316

High

300312

KRT34
Keratin, type I cuticular Ha4

2

0

High-throughput

0.316

High

829127

DDT4L
DNA damage-inducible transcript 4-like protein

2

0

High-throughput

0.316

High

431738

ITB1
Integrin beta-1

2

0

High-throughput

0.313

High

829071

U119A
Protein unc-119 homolog A

1

0

High-throughput

0.282

High

829097

PI3R6
Phosphoinositide 3-kinase regulatory subunit 6

1

0

High-throughput

0.269

Low

829105

CAN12
Calpain-12

1

0

High-throughput

0.269

Low

829056

YPEL3
Protein yippee-like 3

1

0

High-throughput

0.251

Low

124256

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.249

Low

271959

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.249

Low

829113

SPICE
Spindle and centriole-associated protein 1

1

0

High-throughput

0.249

Low

829117

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low

829119

ARK74
Aflatoxin B1 aldehyde reductase member 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025