Protein: RFC3
Replication factor C subunit 3 (Activator 1 38 kDa subunit) (A1 38 kDa subunit) (Activator 1 subunit 3) (Replication factor C 38 kDa subunit) (RF-C 38 kDa subunit) (RFC38)

Gene: RFC3
Organism: Homo sapiens
Interactions: 176
UniProt ID: P40938

Gene Ontology (top 5):
GO:0000731 - DNA synthesis involved in DNA repair
GO:0003677 - DNA binding
GO:0003689 - DNA clamp loader activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

769670

RFC4
Replication factor C subunit 4

11

16

Small-scale

0.977

High

829043

RFC5
Replication factor C subunit 5

4

16

High-throughput

0.892

High

769934

RFC1
Replication factor C subunit 1

3

20

Small-scale

0.853

High

550904

PCNA
Proliferating cell nuclear antigen

3

12

Small-scale

0.827

High

829252

CTF18
Chromosome transmission fidelity protein 18 homolog

2

19

Small-scale

0.806

High

829258

ATAD5
ATPase family AAA domain-containing protein 5

2

20

Small-scale

0.754

High

298581

RAD17
Cell cycle checkpoint protein RAD17

5

20

Small-scale

0.721

High

829263

DCC1
Sister chromatid cohesion protein DCC1

4

7

Small-scale

0.694

High

259565

BRD4
Bromodomain-containing protein 4

4

13

Small-scale

0.692

High

829205

ORC1
Origin recognition complex subunit 1

1

7

High-throughput

0.691

High

769819

RFC2
Replication factor C subunit 2

1

16

High-throughput

0.618

High

829188

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.618

High

371368

MYC
Myc proto-oncogene protein

2

3

High-throughput

0.611

High

284657

KHDR3
KH domain-containing, RNA-binding, signal transduction-associated protein 3

2

1

High-throughput

0.606

High

829228

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

2

1

High-throughput

0.606

High

240969

PRKN
E3 ubiquitin-protein ligase parkin

2

3

High-throughput

0.584

High

588097

RFA2
Replication protein A 32 kDa subunit

2

5

High-throughput

0.584

High

694812

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

3

High-throughput

0.584

High

767589

RFA3
Replication protein A 14 kDa subunit

2

3

High-throughput

0.584

High

829180

CCNF
Cyclin-F

2

2

High-throughput

0.584

High

829194

H4
Histone H4

2

7

High-throughput

0.584

High

829195

H31
Histone H3.1

2

13

High-throughput

0.584

High

829280

MCM9
DNA helicase MCM9

2

5

Small-scale

0.584

High

829200

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

829279

PICK1
PRKCA-binding protein

2

1

High-throughput

0.553

High

140790

NOP56
Nucleolar protein 56

1

3

High-throughput

0.536

High

158408

RFXK
DNA-binding protein RFXANK

1

3

High-throughput

0.536

High

253192

RAD1
Cell cycle checkpoint protein RAD1

1

2

High-throughput

0.536

High

290476

SURF6
Surfeit locus protein 6

1

1

High-throughput

0.536

High

446726

NPM
Nucleophosmin

1

3

High-throughput

0.536

High

487043

PARP1
Poly [ADP-ribose] polymerase 1

1

11

High-throughput

0.536

High

693575

RL10
Large ribosomal subunit protein uL16

1

3

High-throughput

0.536

High

829197

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

3

High-throughput

0.536

High

829198

SSRP1
FACT complex subunit SSRP1

1

8

High-throughput

0.536

High

829240

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.536

High

829261

RAD9A
Cell cycle checkpoint control protein RAD9A

1

3

High-throughput

0.536

High

829266

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.536

High

829282

IBTK
Inhibitor of Bruton tyrosine kinase

1

1

High-throughput

0.536

High

829284

DAXX
Death domain-associated protein 6

1

1

High-throughput

0.536

High

829293

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

2

High-throughput

0.536

High

829287

HECD1
E3 ubiquitin-protein ligase HECTD1

2

7

Small-scale

0.533

High

829181

MAGA9
Melanoma-associated antigen 9

1

0

High-throughput

0.513

High

829217

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

High-throughput

0.513

High

829189

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

High-throughput

0.501

High

829246

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

1

1

High-throughput

0.494

High

182485

GP182
G-protein coupled receptor 182

1

1

High-throughput

0.489

High

488299

PPBI
Intestinal-type alkaline phosphatase

1

1

High-throughput

0.489

High

829202

KLRD1
Natural killer cells antigen CD94

1

1

High-throughput

0.489

High

829215

P2RY6
P2Y purinoceptor 6

1

1

High-throughput

0.489

High

829255

TANK
TRAF family member-associated NF-kappa-B activator

1

1

High-throughput

0.489

High

829285

DNJ5B
DnaJ homolog subfamily C member 5B

1

1

High-throughput

0.489

High

829291

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

7

High-throughput

0.489

High

128825

MEN1
Menin

1

3

High-throughput

0.479

High

131786

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

6

High-throughput

0.479

High

238421

RAD21
Double-strand-break repair protein rad21 homolog

1

4

High-throughput

0.479

High

302416

RNF8
E3 ubiquitin-protein ligase RNF8

1

3

High-throughput

0.479

High

315228

RECQ4
ATP-dependent DNA helicase Q4

1

5

High-throughput

0.479

High

319484

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

324616

HEXI1
Protein HEXIM1

1

2

High-throughput

0.479

High

362907

EGFR
Epidermal growth factor receptor

1

5

High-throughput

0.479

High

400420

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

413335

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

418871

H2A1B
Histone H2A type 1-B/E

1

7

High-throughput

0.479

High

472500

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

3

High-throughput

0.479

High

506695

CTF8
Chromosome transmission fidelity protein 8 homolog

1

2

Small-scale

0.479

High

507637

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

High-throughput

0.479

High

606363

CEBPB
CCAAT/enhancer-binding protein beta

1

8

High-throughput

0.479

High

629620

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

674101

BRD2
Bromodomain-containing protein 2

1

16

High-throughput

0.479

High

754750

H2B1B
Histone H2B type 1-B

1

14

High-throughput

0.479

High

829182

NKX21
Homeobox protein Nkx-2.1

1

4

High-throughput

0.479

High

829184

CDK9
Cyclin-dependent kinase 9

1

2

High-throughput

0.479

High

829185

HDGF
Hepatoma-derived growth factor

1

3

High-throughput

0.479

High

829192

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

829193

RS6
Small ribosomal subunit protein eS6

1

5

High-throughput

0.479

High

829199

EP300
Histone acetyltransferase p300

1

12

High-throughput

0.479

High

829203

TIF1B
Transcription intermediary factor 1-beta

1

5

High-throughput

0.479

High

829204

G3BP1
Ras GTPase-activating protein-binding protein 1

1

3

High-throughput

0.479

High

829206

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

6

High-throughput

0.479

High

829207

BIRC3
Baculoviral IAP repeat-containing protein 3

1

5

High-throughput

0.479

High

829208

SNW1
SNW domain-containing protein 1

1

3

High-throughput

0.479

High

829209

CUL3
Cullin-3

1

4

High-throughput

0.479

High

829212

HAPR1
HUWE1-associated protein modifying stress responses 1

1

1

High-throughput

0.479

High

829213

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

829214

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

829216

PCBP1
Poly(rC)-binding protein 1

1

2

High-throughput

0.479

High

829218

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.479

High

829220

HIF1A
Hypoxia-inducible factor 1-alpha

1

4

High-throughput

0.479

High

829221

IF16
Gamma-interferon-inducible protein 16

1

2

High-throughput

0.479

High

829222

DUS7
Dual specificity protein phosphatase 7

1

1

High-throughput

0.479

High

829234

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.479

High

829235

MEPCE
7SK snRNA methylphosphate capping enzyme

1

2

High-throughput

0.479

High

829236

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

829237

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

6

High-throughput

0.479

High

829239

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

2

Small-scale

0.479

High

829242

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

829247

SIR6
NAD-dependent protein deacylase sirtuin-6

1

1

High-throughput

0.479

High

829248

ZBT38
Zinc finger and BTB domain-containing protein 38

1

2

Small-scale

0.479

High

829249

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

829251

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

3

High-throughput

0.479

High

829253

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

3

Small-scale

0.479

High

829254

ESR2
Estrogen receptor beta

1

6

High-throughput

0.479

High

829257

CI072
Guanine nucleotide exchange factor C9orf72

1

3

High-throughput

0.479

High

829259

CIC
Protein capicua homolog

1

9

High-throughput

0.479

High

829260

CDC5L
Cell division cycle 5-like protein

1

3

High-throughput

0.479

High

829262

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

5

High-throughput

0.479

High

829264

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

4

Small-scale

0.479

High

829265

FACD2
Fanconi anemia group D2 protein

1

7

High-throughput

0.479

High

829267

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

2

High-throughput

0.479

High

829268

SPRTN
DNA-dependent metalloprotease SPRTN

1

3

High-throughput

0.479

High

829269

CCDC8
Coiled-coil domain-containing protein 8

1

2

High-throughput

0.479

High

829271

CHM4B
Charged multivesicular body protein 4b

1

2

High-throughput

0.479

High

829272

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

5

High-throughput

0.479

High

829274

ECT2
Protein ECT2

1

3

High-throughput

0.479

High

829275

BRD7
Bromodomain-containing protein 7

1

8

High-throughput

0.479

High

829276

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

829277

ANLN
Anillin

1

3

High-throughput

0.479

High

829278

FBX6
F-box only protein 6

1

1

High-throughput

0.479

High

829286

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

829289

FZR1
Fizzy-related protein homolog

1

4

High-throughput

0.479

High

829290

FAF1
FAS-associated factor 1

1

2

High-throughput

0.479

High

829292

FAN1
Fanconi-associated nuclease 1

1

1

Small-scale

0.479

High

829295

MAFB
Transcription factor MafB

1

7

High-throughput

0.479

High

171843

ZN263
Zinc finger protein 263

1

0

Small-scale

0.458

High

194029

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

279293

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

536656

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

567283

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.458

High

620181

NUCL
Nucleolin

1

0

High-throughput

0.458

High

767116

MERL
Merlin

1

0

High-throughput

0.458

High

783190

TRI23
E3 ubiquitin-protein ligase TRIM23

1

0

High-throughput

0.458

High

829186

TXTP
Tricarboxylate transport protein, mitochondrial

1

0

High-throughput

0.458

High

829187

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.458

High

829191

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.458

High

829196

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

829201

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

0

High-throughput

0.458

High

829223

DDR2
Discoidin domain-containing receptor 2

1

3

High-throughput

0.457

High

429450

JUN
Transcription factor Jun

1

5

High-throughput

0.445

High

529261

TAU
Microtubule-associated protein tau

1

7

High-throughput

0.445

High

829225

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.445

High

829244

RYBP
RING1 and YY1-binding protein

1

2

High-throughput

0.445

High

136842

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

1

High-throughput

0.437

High

157045

CTRO
Citron Rho-interacting kinase

1

4

High-throughput

0.437

High

293323

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.437

High

411509

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.437

High

829210

TRI29
Tripartite motif-containing protein 29

1

4

Small-scale

0.437

High

829227

RC3H1
Roquin-1

1

2

High-throughput

0.437

High

829229

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.437

High

829233

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

829245

FBXL6
F-box/LRR-repeat protein 6

1

2

High-throughput

0.437

High

829256

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.437

High

829270

ATG5
Autophagy protein 5

1

1

High-throughput

0.437

High

829273

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

829294

PHLA3
Pleckstrin homology-like domain family A member 3

1

1

High-throughput

0.437

High

829183

CEBPA
CCAAT/enhancer-binding protein alpha

1

8

High-throughput

0.408

High

958

SIM26
Small integral membrane protein 26

1

2

High-throughput

0.407

High

829219

FSCN1
Fascin

1

1

Small-scale

0.407

High

829232

PKHG7
Pleckstrin homology domain-containing family G member 7

1

1

High-throughput

0.407

High

580739

PVR
Poliovirus receptor

2

0

High-throughput

0.328

High

829230

ANR40
Ankyrin repeat domain-containing protein 40

2

0

High-throughput

0.316

High

154802

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

1

0

High-throughput

0.279

Low

239017

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.279

Low

749312

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

0

High-throughput

0.279

Low

829226

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

0

High-throughput

0.279

Low

829243

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

829283

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

829211

MESD
LRP chaperone MESD

1

0

High-throughput

0.265

Low

576620

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

0

High-throughput

0.249

Low

829190

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.249

Low

829224

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

829231

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

829238

TM11B
Transmembrane protease serine 11B

1

0

High-throughput

0.249

Low

829250

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

829281

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

1

0

High-throughput

0.249

Low

829288

CLC4E
C-type lectin domain family 4 member E

1

0

High-throughput

0.249

Low

829241

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025