Protein: RFC4
Replication factor C subunit 4 (Activator 1 37 kDa subunit) (A1 37 kDa subunit) (Activator 1 subunit 4) (Replication factor C 37 kDa subunit) (RF-C 37 kDa subunit) (RFC37)

Gene: RFC4
Organism: Homo sapiens
Interactions: 205
UniProt ID: P35249

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005663 - DNA replication factor C complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

769669

RFC5
Replication factor C subunit 5

17

16

Small-scale

0.987

High

769670

RFC3
Replication factor C subunit 3

11

16

Small-scale

0.977

High

769666

RFC2
Replication factor C subunit 2

10

17

Small-scale

0.969

High

298577

RAD17
Cell cycle checkpoint protein RAD17

6

20

Small-scale

0.948

High

550888

PCNA
Proliferating cell nuclear antigen

6

12

Small-scale

0.944

High

769765

ATAD5
ATPase family AAA domain-containing protein 5

6

20

Small-scale

0.940

High

259531

BRD4
Bromodomain-containing protein 4

5

13

Small-scale

0.926

High

769667

RFC1
Replication factor C subunit 1

5

17

Small-scale

0.919

High

769754

CTF18
Chromosome transmission fidelity protein 18 homolog

4

17

Small-scale

0.906

High

253188

RAD1
Cell cycle checkpoint protein RAD1

2

2

High-throughput

0.811

High

240899

PRKN
E3 ubiquitin-protein ligase parkin

2

3

High-throughput

0.754

High

769728

BRD3
Bromodomain-containing protein 3

2

13

High-throughput

0.754

High

371317

MYC
Myc proto-oncogene protein

6

3

High-throughput

0.726

High

769771

RAD9A
Cell cycle checkpoint control protein RAD9A

1

3

High-throughput

0.691

High

769773

DCC1
Sister chromatid cohesion protein DCC1

4

7

High-throughput

0.691

High

506693

CTF8
Chromosome transmission fidelity protein 8 homolog

3

2

High-throughput

0.662

High

769782

RNF41
E3 ubiquitin-protein ligase NRDP1

5

3

Small-scale

0.658

High

767536

RFA3
Replication protein A 14 kDa subunit

3

3

High-throughput

0.656

High

694755

RFA1
Replication protein A 70 kDa DNA-binding subunit

3

3

Small-scale

0.640

High

769700

H31
Histone H3.1

3

13

Small-scale

0.640

High

674091

BRD2
Bromodomain-containing protein 2

1

16

High-throughput

0.618

High

769710

EP300
Histone acetyltransferase p300

1

12

High-throughput

0.618

High

769787

BRD7
Bromodomain-containing protein 7

1

8

High-throughput

0.618

High

769801

UBQL2
Ubiquilin-2

1

1

High-throughput

0.618

High

769686

EPHA4
Ephrin type-A receptor 4

2

0

High-throughput

0.602

High

769729

TAF12
Transcription initiation factor TFIID subunit 12

2

0

High-throughput

0.602

High

769738

TAF2
Transcription initiation factor TFIID subunit 2

2

0

High-throughput

0.602

High

769786

TAF9B
Transcription initiation factor TFIID subunit 9B

2

0

High-throughput

0.602

High

769688

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

2

2

Small-scale

0.595

High

413302

P53
Cellular tumor antigen p53

2

1

High-throughput

0.584

High

588041

RFA2
Replication protein A 32 kDa subunit

2

5

High-throughput

0.584

High

769696

H4
Histone H4

2

7

High-throughput

0.584

High

769789

ANLN
Anillin

2

3

High-throughput

0.584

High

769790

MCM9
DNA helicase MCM9

2

5

Small-scale

0.584

High

769724

I13R2
Interleukin-13 receptor subunit alpha-2

2

2

High-throughput

0.574

High

769758

ESR2
Estrogen receptor beta

2

6

High-throughput

0.571

High

769713

TIF1B
Transcription intermediary factor 1-beta

1

5

High-throughput

0.561

High

74440

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

1

High-throughput

0.536

High

140772

NOP56
Nucleolar protein 56

1

3

High-throughput

0.536

High

261701

HUS1
Checkpoint protein HUS1

1

2

High-throughput

0.536

High

446703

NPM
Nucleophosmin

1

3

High-throughput

0.536

High

487016

PARP1
Poly [ADP-ribose] polymerase 1

1

11

High-throughput

0.536

High

501925

H2AZ
Histone H2A.Z

1

5

High-throughput

0.536

High

541860

TOP1
DNA topoisomerase 1

1

2

High-throughput

0.536

High

693559

RL10
Large ribosomal subunit protein uL16

1

3

High-throughput

0.536

High

769684

HDGF
Hepatoma-derived growth factor

1

3

High-throughput

0.536

High

769693

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

769704

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

3

High-throughput

0.536

High

769708

FAK1
Focal adhesion kinase 1

1

4

High-throughput

0.536

High

769709

SSRP1
FACT complex subunit SSRP1

1

8

High-throughput

0.536

High

769732

H2B2E
Histone H2B type 2-E

1

14

High-throughput

0.536

High

769768

TCPQM
T-complex protein 1 subunit theta-like 2

1

4

High-throughput

0.536

High

769774

HIRP3
HIRA-interacting protein 3

1

1

High-throughput

0.536

High

769794

IBTK
Inhibitor of Bruton tyrosine kinase

1

1

High-throughput

0.536

High

769805

SRPK3
SRSF protein kinase 3

1

7

High-throughput

0.536

High

769811

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

2

High-throughput

0.536

High

769730

FSCN1
Fascin

2

1

Small-scale

0.521

High

769673

NOTC1
Neurogenic locus notch homolog protein 1

1

0

High-throughput

0.513

High

769674

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.513

High

769679

TAF6
Transcription initiation factor TFIID subunit 6

1

0

High-throughput

0.513

High

769722

CAPR1
Caprin-1

1

0

High-throughput

0.513

High

769755

PSPC1
Paraspeckle component 1

1

0

High-throughput

0.513

High

769767

UIMC1
BRCA1-A complex subunit RAP80

1

0

High-throughput

0.513

High

769807

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

0

High-throughput

0.513

High

769814

OAS3
2'-5'-oligoadenylate synthase 3

1

0

High-throughput

0.513

High

769692

SUMO2
Small ubiquitin-related modifier 2

1

3

High-throughput

0.501

High

769760

TANK
TRAF family member-associated NF-kappa-B activator

1

1

High-throughput

0.489

High

769800

SRP68
Signal recognition particle subunit SRP68

1

1

High-throughput

0.489

High

769804

G3BP2
Ras GTPase-activating protein-binding protein 2

1

3

High-throughput

0.489

High

769808

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

7

High-throughput

0.489

High

128807

MEN1
Menin

1

3

High-throughput

0.479

High

131766

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

6

High-throughput

0.479

High

157016

CTRO
Citron Rho-interacting kinase

1

4

High-throughput

0.479

High

159538

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

1

High-throughput

0.479

High

293291

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.479

High

302403

RNF8
E3 ubiquitin-protein ligase RNF8

1

3

High-throughput

0.479

High

315201

RECQ4
ATP-dependent DNA helicase Q4

1

6

High-throughput

0.479

High

319455

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

324591

HEXI1
Protein HEXIM1

1

2

High-throughput

0.479

High

334513

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

3

Small-scale

0.479

High

340836

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

6

High-throughput

0.479

High

362871

EGFR
Epidermal growth factor receptor

1

5

High-throughput

0.479

High

400384

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

411469

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

418861

H2A1B
Histone H2A type 1-B/E

1

7

High-throughput

0.479

High

472481

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

3

High-throughput

0.479

High

504713

FBSP1
F-box/SPRY domain-containing protein 1

1

4

High-throughput

0.479

High

520525

RARA
Retinoic acid receptor alpha

1

6

Small-scale

0.479

High

606327

CEBPB
CCAAT/enhancer-binding protein beta

1

8

High-throughput

0.479

High

664652

CCND1
G1/S-specific cyclin-D1

1

2

High-throughput

0.479

High

713898

PML
Protein PML

1

4

Small-scale

0.479

High

769668

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.479

High

769671

GATA4
Transcription factor GATA-4

1

1

High-throughput

0.479

High

769672

NKX21
Homeobox protein Nkx-2.1

1

4

High-throughput

0.479

High

769676

SOX2
Transcription factor SOX-2

1

11

High-throughput

0.479

High

769680

CDK9
Cyclin-dependent kinase 9

1

2

High-throughput

0.479

High

769683

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

3

High-throughput

0.479

High

769685

PMS1
PMS1 protein homolog 1

1

2

High-throughput

0.479

High

769687

FOXA1
Hepatocyte nuclear factor 3-alpha

1

1

High-throughput

0.479

High

769694

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

769695

RS6
Small ribosomal subunit protein eS6

1

6

High-throughput

0.479

High

769697

H2B1C
Histone H2B type 1-C/E/F/G/I

1

14

High-throughput

0.479

High

769699

1433Z
14-3-3 protein zeta/delta

1

1

High-throughput

0.479

High

769702

H33
Histone H3.3

1

13

High-throughput

0.479

High

769703

VIGLN
Vigilin

1

3

High-throughput

0.479

High

769707

KIF23
Kinesin-like protein KIF23

1

2

High-throughput

0.479

High

769711

NFX1
Transcriptional repressor NF-X1

1

2

High-throughput

0.479

High

769714

G3BP1
Ras GTPase-activating protein-binding protein 1

1

3

High-throughput

0.479

High

769716

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

6

High-throughput

0.479

High

769717

BIRC3
Baculoviral IAP repeat-containing protein 3

1

5

High-throughput

0.479

High

769718

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

769719

SNW1
SNW domain-containing protein 1

1

3

High-throughput

0.479

High

769720

CUL3
Cullin-3

1

4

High-throughput

0.479

High

769725

MDC1
Mediator of DNA damage checkpoint protein 1

1

6

High-throughput

0.479

High

769726

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

1

High-throughput

0.479

High

769727

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

769731

HIF1A
Hypoxia-inducible factor 1-alpha

1

4

High-throughput

0.479

High

769735

MYSM1
Deubiquitinase MYSM1

1

1

Small-scale

0.479

High

769737

ZN746
Zinc finger protein 746

1

1

High-throughput

0.479

High

769740

PAXI1
PAX-interacting protein 1

1

8

High-throughput

0.479

High

769741

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.479

High

769742

MEPCE
7SK snRNA methylphosphate capping enzyme

1

2

High-throughput

0.479

High

769743

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

769744

SETD3
Actin-histidine N-methyltransferase

1

1

High-throughput

0.479

High

769749

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

769751

ZBT38
Zinc finger and BTB domain-containing protein 38

1

2

Small-scale

0.479

High

769752

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

769753

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

3

High-throughput

0.479

High

769756

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

3

Small-scale

0.479

High

769757

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

769764

CI072
Guanine nucleotide exchange factor C9orf72

1

3

High-throughput

0.479

High

769766

CIC
Protein capicua homolog

1

9

High-throughput

0.479

High

769769

CDC5L
Cell division cycle 5-like protein

1

3

High-throughput

0.479

High

769770

RING2
E3 ubiquitin-protein ligase RING2

1

4

High-throughput

0.479

High

769772

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

5

High-throughput

0.479

High

769775

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

4

Small-scale

0.479

High

769776

FACD2
Fanconi anemia group D2 protein

1

7

High-throughput

0.479

High

769778

SPRTN
DNA-dependent metalloprotease SPRTN

1

3

High-throughput

0.479

High

769779

CHM4B
Charged multivesicular body protein 4b

1

2

High-throughput

0.479

High

769780

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

5

High-throughput

0.479

High

769783

ECT2
Protein ECT2

1

3

High-throughput

0.479

High

769785

PIDD1
p53-induced death domain-containing protein 1

1

1

Small-scale

0.479

High

769788

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

769792

WWOX
WW domain-containing oxidoreductase

1

2

High-throughput

0.479

High

769793

PD1L1
Programmed cell death 1 ligand 1

1

1

Small-scale

0.479

High

769798

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

769803

FZR1
Fizzy-related protein homolog

1

4

High-throughput

0.479

High

769806

RUVB2
RuvB-like 2

1

11

High-throughput

0.479

High

769809

FAN1
Fanconi-associated nuclease 1

1

1

Small-scale

0.479

High

769810

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.479

High

769812

MAFB
Transcription factor MafB

1

7

High-throughput

0.479

High

711608

3MG
DNA-3-methyladenine glycosylase

1

0

Small-scale

0.458

High

769682

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

769690

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

769698

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

769701

PRAME
Melanoma antigen preferentially expressed in tumors

1

0

Small-scale

0.458

High

769705

EWS
RNA-binding protein EWS

1

0

High-throughput

0.458

High

769712

TADBP
TAR DNA-binding protein 43

1

0

High-throughput

0.458

High

769745

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

769748

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

0

High-throughput

0.458

High

769777

DDX24
ATP-dependent RNA helicase DDX24

1

0

High-throughput

0.458

High

769791

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

769797

HDAC6
Protein deacetylase HDAC6

1

0

High-throughput

0.458

High

769799

TES
Testin

1

0

High-throughput

0.458

High

273406

KDM4A
Lysine-specific demethylase 4A

1

6

Small-scale

0.445

High

429400

JUN
Transcription factor Jun

1

5

High-throughput

0.445

High

563315

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.445

High

769715

STF1
Steroidogenic factor 1

1

5

Small-scale

0.445

High

769733

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.445

High

769736

PKHA7
Pleckstrin homology domain-containing family A member 7

1

10

High-throughput

0.445

High

769750

RYBP
RING1 and YY1-binding protein

1

2

High-throughput

0.445

High

769784

LN28A
Protein lin-28 homolog A

1

2

High-throughput

0.445

High

769721

TRI29
Tripartite motif-containing protein 29

1

4

Small-scale

0.437

High

769723

GRB7
Growth factor receptor-bound protein 7

1

1

Small-scale

0.437

High

769739

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

769746

ZCH18
Zinc finger CCCH domain-containing protein 18

1

4

High-throughput

0.437

High

769762

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.437

High

769781

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

769802

HECD1
E3 ubiquitin-protein ligase HECTD1

1

7

High-throughput

0.437

High

769747

S2611
Sodium-independent sulfate anion transporter

1

0

High-throughput

0.426

High

769813

MYH4
Myosin-4

1

0

High-throughput

0.426

High

769678

CEBPA
CCAAT/enhancer-binding protein alpha

1

8

High-throughput

0.408

High

946

SIM26
Small integral membrane protein 26

1

2

High-throughput

0.407

High

248678

PEPL
Periplakin

1

3

High-throughput

0.407

High

769689

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

2

High-throughput

0.407

High

769706

TAGL
Transgelin

1

1

High-throughput

0.407

High

769734

LITD1
LINE-1 type transposase domain-containing protein 1

1

1

High-throughput

0.407

High

769759

EVPL
Envoplakin

1

2

High-throughput

0.407

High

342517

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.279

Low

619308

LFA3
Lymphocyte function-associated antigen 3

1

0

High-throughput

0.279

Low

769675

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.279

Low

769677

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.279

Low

769681

RB27A
Ras-related protein Rab-27A

1

0

High-throughput

0.279

Low

389091

FINC
Fibronectin

1

0

High-throughput

0.249

Low

769763

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.249

Low

69480

A2ML1
Alpha-2-macroglobulin-like protein 1

1

0

High-throughput

0.232

Low

328426

SCEL
Sciellin

1

0

High-throughput

0.232

Low

370163

CYTN
Cystatin-SN

1

0

High-throughput

0.232

Low

391787

SMR3B
Submaxillary gland androgen-regulated protein 3B

1

0

High-throughput

0.232

Low

619550

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.232

Low

635826

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

High-throughput

0.232

Low

769691

LYSC
Lysozyme C

1

0

High-throughput

0.232

Low

769761

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.232

Low

769795

SPRR3
Small proline-rich protein 3

1

0

High-throughput

0.232

Low

769796

CRNN
Cornulin

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025