HitPredict

Interactor 1: IGSF3 (O75054)
Immunoglobulin superfamily member 3 (IgSF3) (Glu-Trp-Ile EWI motif-containing protein 3) (EWI-3)
Gene: IGSF3

Interactor 2: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30639242, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~V-set
Common GO terms	GO:0016020 - membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1194 Hs			1 189
+	Hs
		253654 IGSF3_HUMAN (1-1194): 0: 758: 100.00		RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28
+	Hs
		253637 IGSF3_HUMAN (1-1194): 0: 758: 100.00		RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97
+	Hs
		349775 ROBO1_HUMAN (7-547): 2.78e-18: 93.5: 12.35		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		349096 NCAM1_HUMAN (33-559): 4.87e-18: 92.2: 13.96		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		255634 OBSL1_HUMAN (569-1111): 5.19e-26: 118: 11.36		RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97
+	Hs
		349043 ROBO1_HUMAN (7-547): 2.78e-18: 93.5: 12.35		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Hs
		348489 NCAM1_HUMAN (33-559): 4.87e-18: 92.2: 13.96		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Hs
		1070491 ROBO1_HUMAN (7-547): 2.78e-18: 93.5: 12.35		RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28
+	Hs
		530172 NCAM1_HUMAN (33-559): 4.87e-18: 92.2: 13.96		RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28
+	Hs
		350221 SDK2_HUMAN (583-1172): 1.81e-22: 107: 12.14		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		914108 SDK2_HUMAN (583-1172): 1.81e-22: 107: 12.14		RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88
+	Hs
		350746 ROBO1_HUMAN (7-547): 2.78e-18: 93.5: 12.35		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		349841 NCAM1_HUMAN (33-559): 4.87e-18: 92.2: 13.96		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		530160 NCAM1_HUMAN (33-559): 4.87e-18: 92.2: 13.96		RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97
+	Hs
		914506 ROBO1_HUMAN (7-547): 2.78e-18: 93.5: 12.35		RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88
+	Hs
		350405 TITIN_HUMAN (8-138): 9.96e-10: 65.7: 13.24		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		914253 TITIN_HUMAN (8-138): 9.96e-10: 65.7: 13.24		RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88