HitPredict

Interactor 1: IGSF3 (O75054)
Immunoglobulin superfamily member 3 (IgSF3) (Glu-Trp-Ile EWI motif-containing protein 3) (EWI-3)
Gene: IGSF3

Interactor 2: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.80	0.675

Property	Details
Experiments	34079125, 31871319
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~V-set
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1194 Hs			1 196
+	Hs
		253645 IGSF3_HUMAN (1-1194): 0: 758: 100.00		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		253638 IGSF3_HUMAN (1-1194): 0: 758: 100.00		RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67
+	Hs
		253622 IGSF3_HUMAN (1-1194): 0: 758: 100.00		RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57
+	Hs
		253648 IGSF3_HUMAN (1-1194): 0: 758: 100.00		RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53
+	Hs
		253635 IGSF3_HUMAN (1-1194): 0: 758: 100.00		RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54
+	Hs
		253636 IGSF3_HUMAN (1-1194): 0: 758: 100.00		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Hs
		253624 IGSF3_HUMAN (1-1194): 0: 758: 100.00		RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74
+	Hs
		120236 IGSF3_HUMAN (1-1194): 0: 758: 100.00		RHOD_HUMAN (7-182): 3.37e-66: 203: 53.98
+	Hs
		915725 SDK2_HUMAN (583-1172): 1.81e-22: 107: 12.14		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Hs
		925776 ROBO1_HUMAN (7-547): 2.78e-18: 93.5: 12.35		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		894044 MYLK_HUMAN (668-1141): 7.03e-22: 105: 12.15		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Hs
		901110 ROBO1_HUMAN (7-547): 2.78e-18: 93.5: 12.35		RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67
+	Hs
		916112 ROBO1_HUMAN (7-547): 2.78e-18: 93.5: 12.35		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Hs
		530163 NCAM1_HUMAN (33-559): 4.87e-18: 92.2: 13.96		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Hs
		436602 ROBO1_HUMAN (7-547): 2.78e-18: 93.5: 12.35		RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16
+	Hs
		894644 ROBO1_HUMAN (7-547): 2.78e-18: 93.5: 12.35		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Ce
		136793 UNC89_CAEEL (571-775): 1.82e-09: 64.6: 11.01		RAC1_CAEEL (1-196): 5.29e-80: 238: 53.57
+	Hs
		564764 ROBO1_HUMAN (7-547): 2.78e-18: 93.5: 12.35		RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74
+	Ce
		104464 UNC89_CAEEL (571-775): 1.82e-09: 64.6: 11.01		G5EBV3_CAEEL (2-196): 7.03e-76: 227: 48.72
+	Ce
		136800 UNC89_CAEEL (571-775): 1.82e-09: 64.6: 11.01		RHO1_CAEEL (1-196): 4.36e-75: 225: 78.57