Protein: IMA6
Importin subunit alpha-6 (Karyopherin subunit alpha-5)

Gene: IMA6, KPNA5
Organism: Homo sapiens
Interactions: 85
UniProt ID: O15131

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0006606 - protein import into nucleus
GO:0006607 - NLS-bearing protein import into nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

179089

NUP50
Nuclear pore complex protein Nup50

7

20

High-throughput

0.968

High

179070

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

5

10

High-throughput

0.718

High

179036

IMA5
Importin subunit alpha-5

1

8

High-throughput

0.691

High

179047

IMB1
Importin subunit beta-1

1

20

High-throughput

0.691

High

179056

SPOPL
Speckle-type POZ protein-like

3

9

High-throughput

0.675

High

179008

MCES
mRNA cap guanine-N(7) methyltransferase

3

5

High-throughput

0.662

High

179011

IMA7
Importin subunit alpha-7

1

8

High-throughput

0.618

High

179035

RAB7A
Ras-related protein Rab-7a

1

2

High-throughput

0.618

High

179009

SPOP
Speckle-type POZ protein

2

9

Small-scale

0.614

High

179032

CDN1B
Cyclin-dependent kinase inhibitor 1B

2

8

Small-scale

0.611

High

179046

CHD4
Chromodomain-helicase-DNA-binding protein 4

2

20

Small-scale

0.611

High

179086

KBTB4
Kelch repeat and BTB domain-containing protein 4

3

6

Small-scale

0.609

High

179022

CFTR
Cystic fibrosis transmembrane conductance regulator

2

6

High-throughput

0.608

High

179019

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

2

6

High-throughput

0.606

High

179025

LMNB1
Lamin-B1

2

12

High-throughput

0.606

High

179030

MLH1
DNA mismatch repair protein Mlh1

2

3

High-throughput

0.606

High

179031

RAD52
DNA repair protein RAD52 homolog

2

1

High-throughput

0.606

High

179039

PO6F2
POU domain, class 6, transcription factor 2

2

10

High-throughput

0.606

High

179055

ZN326
DBIRD complex subunit ZNF326

2

3

High-throughput

0.606

High

179061

ATOSB
Atos homolog protein B

2

1

High-throughput

0.606

High

179071

KAT5
Histone acetyltransferase KAT5

2

7

High-throughput

0.606

High

179072

DCPS
m7GpppX diphosphatase

2

2

High-throughput

0.606

High

179078

RPC3
DNA-directed RNA polymerase III subunit RPC3

2

5

High-throughput

0.606

High

179083

NMNA1
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

2

7

High-throughput

0.606

High

179023

PTN2
Tyrosine-protein phosphatase non-receptor type 2

2

2

High-throughput

0.584

High

179060

MEPCE
7SK snRNA methylphosphate capping enzyme

2

6

High-throughput

0.584

High

179051

NRF1
Nuclear respiratory factor 1

2

0

High-throughput

0.580

High

179062

SEN54
tRNA-splicing endonuclease subunit Sen54

2

0

High-throughput

0.580

High

179068

SR1IP
Protein SREK1IP1

2

3

High-throughput

0.574

High

179054

LARP7
La-related protein 7

2

7

Small-scale

0.571

High

179024

WT1
Wilms tumor protein

1

8

High-throughput

0.541

High

133065

FOXE1
Forkhead box protein E1

1

5

High-throughput

0.536

High

140661

NOP56
Nucleolar protein 56

1

13

High-throughput

0.536

High

179012

MCE1
mRNA-capping enzyme

1

4

High-throughput

0.536

High

179034

NU153
Nuclear pore complex protein Nup153

1

20

High-throughput

0.536

High

179044

CUL3
Cullin-3

1

13

High-throughput

0.536

High

179045

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

11

High-throughput

0.536

High

179057

NIPBL
Nipped-B-like protein

1

5

High-throughput

0.536

High

179063

RBM45
RNA-binding protein 45

1

1

High-throughput

0.536

High

179064

KLHL7
Kelch-like protein 7

1

3

High-throughput

0.536

High

179066

NOPC1
NOP protein chaperone 1

1

2

High-throughput

0.536

High

179076

MTA3
Metastasis-associated protein MTA3

1

14

High-throughput

0.536

High

179077

AN32E
Acidic leucine-rich nuclear phosphoprotein 32 family member E

1

11

High-throughput

0.536

High

179080

ADNP
Activity-dependent neuroprotector homeobox protein

1

4

High-throughput

0.536

High

179082

EAF6
Chromatin modification-related protein MEAF6

1

2

High-throughput

0.536

High

179084

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

20

High-throughput

0.536

High

179087

LYAR
Cell growth-regulating nucleolar protein

1

4

High-throughput

0.536

High

179088

AIPL1
Aryl-hydrocarbon-interacting protein-like 1

1

0

High-throughput

0.513

High

179029

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

1

11

High-throughput

0.508

High

179027

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

14

Small-scale

0.501

High

179040

RBBP4
Histone-binding protein RBBP4

1

12

Small-scale

0.501

High

179049

TWST1
Twist-related protein 1

1

2

Small-scale

0.501

High

179052

HIF1A
Hypoxia-inducible factor 1-alpha

1

13

Small-scale

0.501

High

179075

EPAS1
Endothelial PAS domain-containing protein 1

1

13

Small-scale

0.501

High

179085

BRMS1
Breast cancer metastasis-suppressor 1

1

0

Small-scale

0.486

High

179043

ATM
Serine-protein kinase ATM

1

6

Small-scale

0.481

High

179090

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

179010

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.479

High

179013

NU155
Nuclear pore complex protein Nup155

1

2

High-throughput

0.479

High

179014

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

7

Small-scale

0.479

High

179016

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.479

High

179017

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

12

High-throughput

0.479

High

179018

MYCN
N-myc proto-oncogene protein

1

7

High-throughput

0.479

High

179020

PARP1
Poly [ADP-ribose] polymerase 1

1

4

High-throughput

0.479

High

179021

TAU
Microtubule-associated protein tau

1

9

High-throughput

0.479

High

179028

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

179033

MCM2
DNA replication licensing factor MCM2

1

6

High-throughput

0.479

High

179037

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

5

High-throughput

0.479

High

179038

H31
Histone H3.1

1

7

High-throughput

0.479

High

179042

SKP2
S-phase kinase-associated protein 2

1

5

Small-scale

0.479

High

179050

E2F4
Transcription factor E2F4

1

2

High-throughput

0.479

High

179053

CL16A
Protein CLEC16A

1

3

High-throughput

0.479

High

179065

SLX4
Structure-specific endonuclease subunit SLX4

1

7

High-throughput

0.479

High

179067

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

7

High-throughput

0.479

High

179069

P66B
Transcriptional repressor p66-beta

1

5

High-throughput

0.479

High

179073

CI072
Guanine nucleotide exchange factor C9orf72

1

4

High-throughput

0.479

High

179074

PHB2
Prohibitin-2

1

5

Small-scale

0.479

High

179079

AICDA
Single-stranded DNA cytosine deaminase

1

5

Small-scale

0.479

High

179026

IL32
Interleukin-32

1

0

Small-scale

0.460

High

179015

ZRAB2
Zinc finger Ran-binding domain-containing protein 2

1

0

High-throughput

0.458

High

179041

AHNK
Neuroblast differentiation-associated protein AHNAK

1

0

High-throughput

0.458

High

179048

SF01
Splicing factor 1

1

7

High-throughput

0.457

High

179059

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.437

High

179081

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.437

High

179058

SYNE3
Nesprin-3

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025