HitPredict

Interactor 1: IGSF3 (O75054)
Immunoglobulin superfamily member 3 (IgSF3) (Glu-Trp-Ile EWI motif-containing protein 3) (EWI-3)
Gene: IGSF3

Interactor 2: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~V-set
Common GO terms	GO:0016020 - membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1194 Hs			1 192
+	Hs
		253624 IGSF3_HUMAN (1-1194): 0: 758: 100.00		RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67
+	Hs
		253622 IGSF3_HUMAN (1-1194): 0: 758: 100.00		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		253673 IGSF3_HUMAN (1-1194): 0: 758: 100.00		RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64
+	Hs
		253635 IGSF3_HUMAN (1-1194): 0: 758: 100.00		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19
+	Hs
		253648 IGSF3_HUMAN (1-1194): 0: 758: 100.00		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		253636 IGSF3_HUMAN (1-1194): 0: 758: 100.00		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		253638 IGSF3_HUMAN (1-1194): 0: 758: 100.00		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		256062 OBSL1_HUMAN (569-1111): 5.19e-26: 118: 11.36		RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64
+	Hs
		925776 ROBO1_HUMAN (7-547): 2.78e-18: 93.5: 12.35		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		564764 ROBO1_HUMAN (7-547): 2.78e-18: 93.5: 12.35		RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67
+	Hs
		894044 MYLK_HUMAN (668-1141): 7.03e-22: 105: 12.15		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		1331019 ROBO1_HUMAN (7-547): 2.78e-18: 93.5: 12.35		RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64
+	Hs
		894644 ROBO1_HUMAN (7-547): 2.78e-18: 93.5: 12.35		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		901110 ROBO1_HUMAN (7-547): 2.78e-18: 93.5: 12.35		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		436602 ROBO1_HUMAN (7-547): 2.78e-18: 93.5: 12.35		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45
+	Ce
		136793 UNC89_CAEEL (571-775): 1.82e-09: 64.6: 11.01		RAC1_CAEEL (1-192): 2.2e-83: 246: 82.81
+	Ce
		104464 UNC89_CAEEL (571-775): 1.82e-09: 64.6: 11.01		G5EBV3_CAEEL (2-192): 6.22e-78: 232: 65.45
+	Ce
		136794 UNC89_CAEEL (571-775): 1.82e-09: 64.6: 11.01		CDC42_CAEEL (1-192): 5.89e-76: 227: 69.27
+	Ce
		136800 UNC89_CAEEL (571-775): 1.82e-09: 64.6: 11.01		RHO1_CAEEL (5-192): 4.91e-75: 225: 59.04