HitPredict

Interactor 1: SH21A (O60880)
SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)
Gene: SH2D1A

Interactor 2: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	16983070
Identification Methods	pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 128 Hs			1 191
+	Hs
		601202 ABL2_HUMAN (1-127): 1.86e-40: 144: 27.48		RHOQ_HUMAN (4-187): 7.38e-91: 266: 67.94
+	Hs
		462976 YES_HUMAN (1-127): 5.29e-40: 141: 19.40		RHOQ_HUMAN (4-187): 7.38e-91: 266: 67.94
+	Hs
		463321 LYN_HUMAN (1-125): 1.58e-39: 139: 19.85		RHOQ_HUMAN (4-187): 7.38e-91: 266: 67.94
+	Hs
		840986 ABL2_HUMAN (1-127): 1.86e-40: 144: 27.48		RHOJ_HUMAN (2-188): 2.68e-85: 252: 64.17
+	Hs
		463224 YES_HUMAN (1-127): 5.29e-40: 141: 19.40		RHOJ_HUMAN (2-188): 2.68e-85: 252: 64.17
+	Hs
		840944 ABL2_HUMAN (1-127): 1.86e-40: 144: 27.48		RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31
+	Hs
		463050 YES_HUMAN (1-127): 5.29e-40: 141: 19.40		RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31
+	Hs
		840940 ABL2_HUMAN (1-127): 1.86e-40: 144: 27.48		CDC42_HUMAN (1-191): 9.95e-80: 237: 100.00
+	Hs
		463041 YES_HUMAN (1-127): 5.29e-40: 141: 19.40		CDC42_HUMAN (1-191): 9.95e-80: 237: 100.00
+	Hs
		463059 YES_HUMAN (1-127): 5.29e-40: 141: 19.40		RHOG_HUMAN (1-191): 7.33e-80: 237: 60.73
+	Hs
		580912 ABL2_HUMAN (1-127): 1.86e-40: 144: 27.48		RAC2_HUMAN (1-191): 1.01e-77: 232: 68.75
+	Hs
		463043 YES_HUMAN (1-127): 5.29e-40: 141: 19.40		RHOA_HUMAN (5-191): 2.51e-78: 233: 53.48
+	Hs
		462971 YES_HUMAN (1-127): 5.29e-40: 141: 19.40		RAC2_HUMAN (1-191): 1.01e-77: 232: 68.75
+	Hs
		463312 LYN_HUMAN (1-125): 1.58e-39: 139: 19.85		RAC2_HUMAN (1-191): 1.01e-77: 232: 68.75
+	Hs
		840939 ABL2_HUMAN (1-127): 1.86e-40: 144: 27.48		RAC3_HUMAN (1-177): 7.58e-76: 227: 72.32
+	Hs
		462947 YES_HUMAN (1-127): 5.29e-40: 141: 19.40		RHOC_HUMAN (5-191): 3.38e-76: 228: 52.41
+	Hs
		463040 YES_HUMAN (1-127): 5.29e-40: 141: 19.40		RAC3_HUMAN (1-177): 7.58e-76: 227: 72.32
+	Hs
		463280 LYN_HUMAN (1-125): 1.58e-39: 139: 19.85		RHOC_HUMAN (5-191): 3.38e-76: 228: 52.41
+	Hs
		463428 LYN_HUMAN (1-125): 1.58e-39: 139: 19.85		RAC3_HUMAN (1-177): 7.58e-76: 227: 72.32
+	Hs
		463136 YES_HUMAN (1-127): 5.29e-40: 141: 19.40		RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82