HitPredict

Interactor 1: BRD4 (O60885)
Bromodomain-containing protein 4 (Protein HUNK1)
Gene: BRD4

Interactor 2: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	31239290, 32416067, 30554943
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0004674 - protein serine/threonine kinase activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005694 - chromosome and 1 others more... GO:0006338 - chromatin remodeling
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1362 Hs			1 765
+	Hs
		542032 BRD3_HUMAN (37-737): 8.76e-57: 213: 47.73		TOP1_HUMAN (1-765): 0: 952: 100.00
+	Hs
		541839 BRD2_HUMAN (3-737): 5.3e-54: 206: 46.43		TOP1_HUMAN (1-765): 0: 952: 100.00
+	Hs
		542233 BRD7_HUMAN (238-731): 9.86e-30: 129: 10.56		TOP1_HUMAN (1-765): 0: 952: 100.00
+	Hs
		542095 PB1_HUMAN (15-951): 7.52e-20: 98.6: 11.32		TOP1_HUMAN (1-765): 0: 952: 100.00
+	Rn
		1231097 Q6AYL3_RAT (336-596): 1.04e-18: 90.9: 22.61		TOP1_RAT (1-765): 0: 944: 96.48
+	Hs
		260085 BRD4_HUMAN (1-1362): 1.08e-122: 416: 100.00		NIPBL_HUMAN (2-213): 5.36e-35: 146: 14.29
+	Hs
		1141173 BRD3_HUMAN (37-737): 8.76e-57: 213: 47.73		NIPBL_HUMAN (2-213): 5.36e-35: 146: 14.29