HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: BRD3 (Q15059)
Bromodomain-containing protein 3 (RING3-like protein)
Gene: BRD3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	30554943
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0004674 - protein serine/threonine kinase activity GO:0005634 - nucleus GO:0006338 - chromatin remodeling
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 765 Hs			1 726
+	Hs
		541839 TOP1_HUMAN (1-765): 0: 952: 100.00		BRD2_HUMAN (5-700): 8.79e-139: 429: 57.95
+	Hs
		259356 TOP1_HUMAN (1-765): 0: 952: 100.00		BRD4_HUMAN (3-644): 3.51e-104: 349: 52.55
+	Hs
		542280 TOP1_HUMAN (1-765): 0: 952: 100.00		ZMYD8_HUMAN (3-713): 1.39e-58: 217: 12.28
+	Rn
		1231097 TOP1_RAT (1-765): 0: 944: 96.48		Q6AYL3_RAT (282-556): 1.42e-33: 133: 22.83
+	Hs
		541912 TOP1_HUMAN (1-765): 0: 952: 100.00		BRPF1_HUMAN (20-291): 2.19e-26: 117: 14.39
+	Hs
		542095 TOP1_HUMAN (1-765): 0: 952: 100.00		PB1_HUMAN (152-486): 2.23e-20: 99.1: 12.85
+	Hs
		1141173 NIPBL_HUMAN (2-213): 5.36e-35: 146: 14.29		BRD3_HUMAN (1-702): 1.03e-155: 470: 100.00
+	Hs
		260085 NIPBL_HUMAN (2-213): 5.36e-35: 146: 14.29		BRD4_HUMAN (3-644): 3.51e-104: 349: 52.55