HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: BRD2 (P25440)
Bromodomain-containing protein 2 (O27.1.1)
Gene: BRD2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	31753913, 30554943
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0004674 - protein serine/threonine kinase activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 765 Hs			1 801
+	Hs
		542032 TOP1_HUMAN (1-765): 0: 952: 100.00		BRD3_HUMAN (53-764): 8.33e-122: 384: 56.56
+	Rn
		1231097 TOP1_RAT (1-765): 0: 944: 96.48		Q6AYL3_RAT (323-598): 3.85e-35: 138: 24.28
+	Hs
		542233 TOP1_HUMAN (1-765): 0: 952: 100.00		BRD7_HUMAN (25-283): 2.94e-29: 126: 17.28
+	Hs
		259356 TOP1_HUMAN (1-765): 0: 952: 100.00		BRD4_HUMAN (291-641): 4.15e-23: 108: 17.38
+	Hs
		542242 TOP1_HUMAN (1-765): 0: 952: 100.00		BAZ1A_HUMAN (49-197): 1.08e-22: 106: 21.94
+	Hs
		542095 TOP1_HUMAN (1-765): 0: 952: 100.00		PB1_HUMAN (306-773): 2.04e-17: 89.5: 12.33
+	Hs
		1141173 NIPBL_HUMAN (2-213): 5.36e-35: 146: 14.29		BRD3_HUMAN (53-764): 8.33e-122: 384: 56.56
+	Hs
		260085 NIPBL_HUMAN (2-213): 5.36e-35: 146: 14.29		BRD4_HUMAN (291-641): 4.15e-23: 108: 17.38