HitPredict

Interactor 1: CYC8 (P14922)
General transcriptional corepressor CYC8 (Glucose repression mediator protein CYC8)
Gene: CYC8

Interactor 2: TUP1 (P16649)
General transcriptional corepressor TUP1 (Flocculation suppressor protein) (Glucose repression regulatory protein TUP1) (Repressor AER2)
Gene: TUP1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.991

The method score is based on:

Property Details
Experiments 9111019, 10722750, 2038333, 11805837, 8008070, 8943325, 26257283, 29053708, 30689022, 17634984, 18467557, 37968396, 21552514, 11069890, 10722672, 10802055, 11095729, 11525400, 22707714, 14525981 and 1 others

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Identification Methods biochemical, affinity chromatography technology, molecular sieving, surface plasmon resonance, biophysical, experimental interaction detection, coimmunoprecipitation, anti tag coimmunoprecipitation, pull down, two hybrid and 4 others

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Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains TPR_16~WD40
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0006972 - hyperosmotic response
and 4 others

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Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 966
Sc

1 713
+ Sp
+ Hs
+ Dm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Ca
+ Hs
+ Hs
+ Sp
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024