HitPredict

Interactor 1: BRD4 (O60885)
Bromodomain-containing protein 4 (Protein HUNK1)
Gene: BRD4

Interactor 2: RFC4 (P35249)
Replication factor C subunit 4 (Activator 1 37 kDa subunit) (A1 37 kDa subunit) (Activator 1 subunit 4) (Replication factor C 37 kDa subunit) (RF-C 37 kDa subunit) (RFC37)
Gene: RFC4

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.926

Property	Details
Experiments	12192049, 31753913, 32416067, 24981860, 30554943
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	AAA~Bromodomain
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0019899 - enzyme binding
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 1362 Hs			1 363
+	Hs
		259532 BRD4_HUMAN (1-1362): 1.08e-122: 416: 100.00		RFC2_HUMAN (1-358): 8.75e-89: 272: 33.80
+	Hs
		259564 BRD4_HUMAN (1-1362): 1.08e-122: 416: 100.00		RFC5_HUMAN (26-356): 1.57e-82: 256: 36.45
+	Hs
		259565 BRD4_HUMAN (1-1362): 1.08e-122: 416: 100.00		RFC3_HUMAN (38-361): 5.37e-68: 219: 24.21
+	Hs
		769728 BRD3_HUMAN (37-737): 8.76e-57: 213: 47.73		RFC4_HUMAN (1-363): 7.89e-109: 324: 100.00
+	Hs
		674091 BRD2_HUMAN (3-737): 5.3e-54: 206: 46.43		RFC4_HUMAN (1-363): 7.89e-109: 324: 100.00
+	Hs
		769863 BRD3_HUMAN (37-737): 8.76e-57: 213: 47.73		RFC2_HUMAN (1-358): 8.75e-89: 272: 33.80
+	Hs
		674092 BRD2_HUMAN (3-737): 5.3e-54: 206: 46.43		RFC2_HUMAN (1-358): 8.75e-89: 272: 33.80
+	Hs
		829086 BRD3_HUMAN (37-737): 8.76e-57: 213: 47.73		RFC5_HUMAN (26-356): 1.57e-82: 256: 36.45
+	Hs
		674100 BRD2_HUMAN (3-737): 5.3e-54: 206: 46.43		RFC5_HUMAN (26-356): 1.57e-82: 256: 36.45
+	Hs
		769787 BRD7_HUMAN (238-731): 9.86e-30: 129: 10.56		RFC4_HUMAN (1-363): 7.89e-109: 324: 100.00
+	Hs
		674101 BRD2_HUMAN (3-737): 5.3e-54: 206: 46.43		RFC3_HUMAN (38-361): 5.37e-68: 219: 24.21
+	Hs
		769910 BRD7_HUMAN (238-731): 9.86e-30: 129: 10.56		RFC2_HUMAN (1-358): 8.75e-89: 272: 33.80
+	Hs
		829275 BRD7_HUMAN (238-731): 9.86e-30: 129: 10.56		RFC3_HUMAN (38-361): 5.37e-68: 219: 24.21