Protein: RFC2
Replication factor C subunit 2 (Activator 1 40 kDa subunit) (A1 40 kDa subunit) (Activator 1 subunit 2) (Replication factor C 40 kDa subunit) (RF-C 40 kDa subunit) (RFC40)

Gene: RFC2
Organism: Homo sapiens
Interactions: 161
UniProt ID: P35250

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005663 - DNA replication factor C complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

769666

RFC4
Replication factor C subunit 4

10

17

Small-scale

0.969

High

769818

RFC5
Replication factor C subunit 5

9

17

Small-scale

0.965

High

550889

PCNA
Proliferating cell nuclear antigen

6

13

Small-scale

0.946

High

298578

RAD17
Cell cycle checkpoint protein RAD17

5

20

Small-scale

0.931

High

259532

BRD4
Bromodomain-containing protein 4

4

13

Small-scale

0.902

High

769815

RFC1
Replication factor C subunit 1

3

17

Small-scale

0.817

High

680790

PSA1
Proteasome subunit alpha type-1

2

1

High-throughput

0.783

High

240900

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.754

High

769863

BRD3
Bromodomain-containing protein 3

2

13

High-throughput

0.754

High

769884

CTF18
Chromosome transmission fidelity protein 18 homolog

1

17

Small-scale

0.724

High

769896

RAD9A
Cell cycle checkpoint control protein RAD9A

1

3

High-throughput

0.691

High

694756

RFA1
Replication protein A 70 kDa DNA-binding subunit

4

3

Small-scale

0.676

High

769900

DCC1
Sister chromatid cohesion protein DCC1

3

8

High-throughput

0.667

High

371318

MYC
Myc proto-oncogene protein

3

3

High-throughput

0.656

High

767537

RFA3
Replication protein A 14 kDa subunit

3

3

High-throughput

0.656

High

588042

RFA2
Replication protein A 32 kDa subunit

3

5

High-throughput

0.640

High

769837

H31
Histone H3.1

3

14

Small-scale

0.640

High

507602

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

High-throughput

0.618

High

674092

BRD2
Bromodomain-containing protein 2

1

16

High-throughput

0.618

High

769819

RFC3
Replication factor C subunit 3

1

16

High-throughput

0.618

High

769830

RD23B
UV excision repair protein RAD23 homolog B

1

2

High-throughput

0.618

High

769843

EP300
Histone acetyltransferase p300

1

12

High-throughput

0.618

High

769910

BRD7
Bromodomain-containing protein 7

1

8

High-throughput

0.618

High

487017

PARP1
Poly [ADP-ribose] polymerase 1

2

11

High-throughput

0.611

High

769865

ZIC1
Zinc finger protein ZIC 1

2

1

High-throughput

0.606

High

769817

BRCA1
Breast cancer type 1 susceptibility protein

2

2

High-throughput

0.584

High

769835

H4
Histone H4

2

8

High-throughput

0.584

High

769868

IF16
Gamma-interferon-inducible protein 16

2

2

High-throughput

0.584

High

769914

MCM9
DNA helicase MCM9

2

5

Small-scale

0.584

High

395595

ESR1
Estrogen receptor

2

6

High-throughput

0.571

High

769887

ESR2
Estrogen receptor beta

2

6

High-throughput

0.571

High

74441

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

1

High-throughput

0.536

High

140773

NOP56
Nucleolar protein 56

1

3

High-throughput

0.536

High

261702

HUS1
Checkpoint protein HUS1

1

2

High-throughput

0.536

High

446704

NPM
Nucleophosmin

1

3

High-throughput

0.536

High

563316

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

601579

HMGA1
High mobility group protein HMG-I/HMG-Y

1

1

High-throughput

0.536

High

693560

RL10
Large ribosomal subunit protein uL16

1

4

High-throughput

0.536

High

769821

KSYK
Tyrosine-protein kinase SYK

1

5

High-throughput

0.536

High

769833

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

769840

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

3

High-throughput

0.536

High

769842

SSRP1
FACT complex subunit SSRP1

1

8

High-throughput

0.536

High

769852

CUL3
Cullin-3

1

4

High-throughput

0.536

High

769869

H2B2E
Histone H2B type 2-E

1

16

High-throughput

0.536

High

769878

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

2

High-throughput

0.536

High

769880

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.536

High

769888

CSN5
COP9 signalosome complex subunit 5

1

3

High-throughput

0.536

High

769894

TCPQM
T-complex protein 1 subunit theta-like 2

1

4

High-throughput

0.536

High

769911

TF7L2
Transcription factor 7-like 2

1

11

High-throughput

0.536

High

769918

DAXX
Death domain-associated protein 6

1

1

High-throughput

0.536

High

571564

IRF2
Interferon regulatory factor 2

1

0

High-throughput

0.513

High

769926

EXOS1
Exosome complex component CSL4

1

0

High-throughput

0.513

High

769832

SUMO2
Small ubiquitin-related modifier 2

1

4

High-throughput

0.501

High

769924

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

8

High-throughput

0.489

High

769913

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

Small-scale

0.480

High

128808

MEN1
Menin

1

3

High-throughput

0.479

High

131767

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

6

High-throughput

0.479

High

157017

CTRO
Citron Rho-interacting kinase

1

4

High-throughput

0.479

High

159539

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

1

High-throughput

0.479

High

190832

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

4

High-throughput

0.479

High

247703

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

293292

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.479

High

315202

RECQ4
ATP-dependent DNA helicase Q4

1

5

High-throughput

0.479

High

340837

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

6

High-throughput

0.479

High

400385

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

418862

H2A1B
Histone H2A type 1-B/E

1

8

High-throughput

0.479

High

472482

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

3

High-throughput

0.479

High

664653

CCND1
G1/S-specific cyclin-D1

1

2

High-throughput

0.479

High

754741

H2B1B
Histone H2B type 1-B

1

16

High-throughput

0.479

High

766239

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

769820

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

769822

GATA4
Transcription factor GATA-4

1

1

High-throughput

0.479

High

769823

NKX21
Homeobox protein Nkx-2.1

1

4

High-throughput

0.479

High

769824

SOX2
Transcription factor SOX-2

1

11

High-throughput

0.479

High

769825

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

4

High-throughput

0.479

High

769826

CENPA
Histone H3-like centromeric protein A

1

14

High-throughput

0.479

High

769828

PMS1
PMS1 protein homolog 1

1

4

High-throughput

0.479

High

769829

PMS2
Mismatch repair endonuclease PMS2

1

4

High-throughput

0.479

High

769834

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

769838

H33
Histone H3.3

1

14

High-throughput

0.479

High

769839

VIGLN
Vigilin

1

3

High-throughput

0.479

High

769841

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

769844

TP53B
TP53-binding protein 1

1

3

High-throughput

0.479

High

769845

NFX1
Transcriptional repressor NF-X1

1

2

High-throughput

0.479

High

769846

TIF1B
Transcription intermediary factor 1-beta

1

5

High-throughput

0.479

High

769847

SKP2
S-phase kinase-associated protein 2

1

2

Small-scale

0.479

High

769848

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

6

High-throughput

0.479

High

769849

BIRC3
Baculoviral IAP repeat-containing protein 3

1

5

High-throughput

0.479

High

769850

SNW1
SNW domain-containing protein 1

1

3

High-throughput

0.479

High

769851

CUL1
Cullin-1

1

4

Small-scale

0.479

High

769854

HLTF
Helicase-like transcription factor

1

7

High-throughput

0.479

High

769856

MDC1
Mediator of DNA damage checkpoint protein 1

1

6

High-throughput

0.479

High

769858

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

1

Small-scale

0.479

High

769859

HAPR1
HUWE1-associated protein modifying stress responses 1

1

1

High-throughput

0.479

High

769860

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

1

High-throughput

0.479

High

769861

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

769862

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

769864

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.479

High

769867

HIF1A
Hypoxia-inducible factor 1-alpha

1

4

High-throughput

0.479

High

769871

IFIX
Pyrin and HIN domain-containing protein 1

1

2

High-throughput

0.479

High

769873

PAXI1
PAX-interacting protein 1

1

8

High-throughput

0.479

High

769874

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

769875

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

6

High-throughput

0.479

High

769877

SETD3
Actin-histidine N-methyltransferase

1

1

High-throughput

0.479

High

769879

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

1

3

Small-scale

0.479

High

769883

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

3

High-throughput

0.479

High

769885

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

3

Small-scale

0.479

High

769886

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

769892

CI072
Guanine nucleotide exchange factor C9orf72

1

3

High-throughput

0.479

High

769895

CDC5L
Cell division cycle 5-like protein

1

3

High-throughput

0.479

High

769897

PITX2
Pituitary homeobox 2

1

3

High-throughput

0.479

High

769898

BARD1
BRCA1-associated RING domain protein 1

1

4

High-throughput

0.479

High

769899

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

5

High-throughput

0.479

High

769901

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

4

Small-scale

0.479

High

769902

FACD2
Fanconi anemia group D2 protein

1

7

High-throughput

0.479

High

769903

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

2

High-throughput

0.479

High

769904

SPRTN
DNA-dependent metalloprotease SPRTN

1

3

High-throughput

0.479

High

769905

CCDC8
Coiled-coil domain-containing protein 8

1

2

High-throughput

0.479

High

769906

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

7

High-throughput

0.479

High

769908

ECT2
Protein ECT2

1

3

High-throughput

0.479

High

769912

ANLN
Anillin

1

3

High-throughput

0.479

High

769916

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

769917

WWOX
WW domain-containing oxidoreductase

1

2

High-throughput

0.479

High

769919

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

769921

FZR1
Fizzy-related protein homolog

1

4

High-throughput

0.479

High

769923

CE164
Centrosomal protein of 164 kDa

1

5

High-throughput

0.479

High

769927

ZN330
Zinc finger protein 330

1

1

High-throughput

0.479

High

769929

MAFB
Transcription factor MafB

1

7

High-throughput

0.479

High

385505

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

639357

5NTD
5'-nucleotidase

1

0

High-throughput

0.458

High

769816

T2FA
General transcription factor IIF subunit 1

1

0

High-throughput

0.458

High

769855

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

769866

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

769876

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

769889

DDX11
ATP-dependent DNA helicase DDX11

1

0

Small-scale

0.458

High

769890

CDCA5
Sororin

1

0

High-throughput

0.458

High

769930

SCC4
MAU2 chromatid cohesion factor homolog

1

0

High-throughput

0.458

High

273407

KDM4A
Lysine-specific demethylase 4A

1

6

Small-scale

0.445

High

429401

JUN
Transcription factor Jun

1

5

High-throughput

0.445

High

529212

TAU
Microtubule-associated protein tau

1

7

High-throughput

0.445

High

769857

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

2

High-throughput

0.445

High

769881

RYBP
RING1 and YY1-binding protein

1

2

High-throughput

0.445

High

769909

LN28A
Protein lin-28 homolog A

1

2

High-throughput

0.445

High

769836

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

1

High-throughput

0.437

High

769853

TRI29
Tripartite motif-containing protein 29

1

4

Small-scale

0.437

High

769872

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

769891

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.437

High

769907

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

769920

HECD1
E3 ubiquitin-protein ligase HECTD1

1

7

High-throughput

0.437

High

769922

LIMC1
LIM and calponin homology domains-containing protein 1

1

3

High-throughput

0.437

High

769928

PHLA3
Pleckstrin homology-like domain family A member 3

1

1

High-throughput

0.437

High

769893

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

769827

CEBPA
CCAAT/enhancer-binding protein alpha

1

8

High-throughput

0.408

High

769831

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

3

High-throughput

0.407

High

169460

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

0

High-throughput

0.316

High

769870

OTU1
Ubiquitin thioesterase OTU1

2

0

High-throughput

0.316

High

531010

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

0

Small-scale

0.313

High

328636

VAMP5
Vesicle-associated membrane protein 5

1

0

High-throughput

0.279

Low

769925

KLH20
Kelch-like protein 20

1

0

Small-scale

0.251

Low

769882

CEP76
Centrosomal protein of 76 kDa

1

0

High-throughput

0.249

Low

769915

SO1C1
Solute carrier organic anion transporter family member 1C1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025