HitPredict

Interactor 1: TP4A3 (O75365)
Protein tyrosine phosphatase type IVA 3 (EC 3.1.3.48) (PRL-R) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3)
Gene: PTP4A3

Interactor 2: ECM29 (Q5VYK3)
Proteasome adapter and scaffold protein ECM29 (Ecm29 proteasome adapter and scaffold) (Proteasome-associated protein ECM29 homolog)
Gene: ECPAS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	17353931
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005769 - early endosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 173 Hs			1 1845
+	Hs
		985181 DUS2_HUMAN (2-154): 7.14e-31: 115: 18.71		ECM29_HUMAN (1-1845): 0: 1279: 100.00
+	Hs
		1047843 CC14A_HUMAN (5-169): 4.17e-36: 133: 23.78		CKAP5_HUMAN (817-1838): 1.5e-38: 161: 11.55
+	Mm
		139429 PTEN_MOUSE (5-163): 2.46e-41: 144: 18.86		CAND1_MOUSE (282-1301): 3.43e-34: 146: 12.77
+	Hs
		890725 PTEN_HUMAN (5-163): 2.34e-41: 144: 18.86		CAND1_HUMAN (282-1301): 2.08e-34: 146: 12.77
+	Sc
		707911 CDC14_YEAST (11-169): 1.4e-37: 137: 22.73		GCN1_YEAST (3-1436): 5.59e-36: 152: 13.40
+	Sp
		1013477 FLP1_SCHPO (3-160): 6.58e-39: 140: 21.97		GCN1_SCHPO (364-1573): 6.67e-33: 142: 13.79
+	Hs
		260591 TP4A3_HUMAN (1-173): 7.13e-57: 177: 100.00		GCN1_HUMAN (34-1064): 1.01e-12: 75.9: 11.52
+	Hs
		155496 TP4A3_HUMAN (1-173): 7.13e-57: 177: 100.00		TNPO2_HUMAN (412-1129): 5.49e-09: 63.2: 10.00
+	Hs
		127228 PTEN_HUMAN (5-163): 2.34e-41: 144: 18.86		IPO5_HUMAN (260-1256): 3.58e-16: 87.1: 10.19
+	Hs
		1167728 TPTE2_HUMAN (6-168): 1.11e-42: 150: 15.85		GCN1_HUMAN (34-1064): 1.01e-12: 75.9: 11.52
+	Hs
		672165 TENS2_HUMAN (4-168): 8.07e-39: 142: 13.74		2AAA_HUMAN (1242-1703): 6.29e-14: 79.2: 13.42
+	Hs
		879832 TPTE_HUMAN (6-168): 3.19e-40: 144: 15.30		GCN1_HUMAN (34-1064): 1.01e-12: 75.9: 11.52
+	Hs
		56511 PTPC1_HUMAN (2-171): 8.66e-36: 133: 20.73		2AAA_HUMAN (1242-1703): 6.29e-14: 79.2: 13.42
+	Hs
		253731 AUXI_HUMAN (9-151): 2.72e-33: 126: 15.48		2AAA_HUMAN (1242-1703): 6.29e-14: 79.2: 13.42
+	Hs
		127251 DUS2_HUMAN (2-154): 7.14e-31: 115: 18.71		IPO5_HUMAN (260-1256): 3.58e-16: 87.1: 10.19
+	Hs
		56512 PTPC1_HUMAN (2-171): 8.66e-36: 133: 20.73		2AAB_HUMAN (1115-1669): 2.22e-10: 67.7: 14.97
+	Hs
		672262 DUS9_HUMAN (18-168): 1.2e-32: 121: 19.36		2AAA_HUMAN (1242-1703): 6.29e-14: 79.2: 13.42
+	Hs
		985191 DUS2_HUMAN (2-154): 7.14e-31: 115: 18.71		GCN1_HUMAN (34-1064): 1.01e-12: 75.9: 11.52
+	Hs
		1273211 DUS23_HUMAN (30-161): 2.35e-28: 104: 26.32		TNPO1_HUMAN (410-1097): 3.23e-13: 77.1: 12.20