HitPredict

Interactor 1: TRIM3 (O75382)
Tripartite motif-containing protein 3 (EC 2.3.2.27) (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97)
Gene: TRIM3

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35563538, 25011449
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000209 - protein polyubiquitination GO:0005737 - cytoplasm GO:0005794 - Golgi apparatus GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 744 Hs			1 768
+	Hs
		1042484 TRIM2_HUMAN (1-744): 0: 565: 66.67		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042406 TRI56_HUMAN (1-742): 7.31e-89: 297: 20.87		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1023272 TRI32_HUMAN (1-742): 1.56e-84: 283: 16.38		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		584956 RO52_HUMAN (18-481): 1.33e-82: 272: 14.97		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042261 TRI11_HUMAN (9-480): 4.68e-74: 249: 18.58		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042482 TRIM5_HUMAN (15-446): 1.97e-70: 240: 16.60		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1041794 TRI68_HUMAN (14-493): 3.04e-68: 234: 14.12		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		536817 TRI27_HUMAN (9-478): 8.29e-67: 231: 15.26		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		170357 TIF1A_HUMAN (21-327): 8.05e-63: 229: 17.32		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		175678 TRI18_HUMAN (12-293): 2.93e-62: 222: 18.31		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042849 TRI33_HUMAN (21-323): 6.99e-57: 212: 20.50		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		734621 TRI23_HUMAN (18-169): 3.18e-13: 75.1: 27.78		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1041843 TRI65_HUMAN (20-248): 5.4e-13: 73.9: 26.20		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		536818 TRI27_HUMAN (9-478): 8.29e-67: 231: 15.26		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		584955 RO52_HUMAN (18-481): 1.33e-82: 272: 14.97		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		536962 TRI27_HUMAN (9-478): 8.29e-67: 231: 15.26		CUL5_HUMAN (25-768): 0: 597: 23.77