HitPredict

Interactor 1: SRS10 (O75494)
Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein)
Gene: SRSF10

Interactor 2: SRSF5 (Q13243)
Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5)
Gene: SRSF5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006376 - mRNA splice site recognition and 1 others more... GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 262 Hs			1 272
+	Zm
		30171 A0A1D6K4S7_MAIZE (1-94): 1.05e-30: 120: 39.00		A0A1D6M1U3_MAIZE (2-184): 1.23e-65: 210: 34.20
+	At
		1338059 SL30A_ARATH (9-244): 8.07e-42: 145: 33.48		SR30_ARATH (6-191): 3.33e-56: 183: 34.38
+	Hs
		992863 SRS12_HUMAN (1-251): 1.31e-38: 137: 46.33		SRSF1_HUMAN (2-170): 6.55e-57: 184: 43.68
+	Hs
		993783 SRS12_HUMAN (1-251): 1.31e-38: 137: 46.33		SRSF4_HUMAN (5-265): 3.78e-51: 176: 53.64
+	Hs
		266972 SRS10_HUMAN (1-262): 2.41e-34: 126: 100.00		SRSF1_HUMAN (2-170): 6.55e-57: 184: 43.68
+	At
		186869 SL30A_ARATH (9-244): 8.07e-42: 145: 33.48		SR34_ARATH (6-268): 3.39e-47: 161: 31.90
+	At
		1163070 CYP59_ARATH (6-259): 5.13e-31: 121: 19.29		SR30_ARATH (6-191): 3.33e-56: 183: 34.38
+	Hs
		1029020 SRS12_HUMAN (1-251): 1.31e-38: 137: 46.33		SRSF6_HUMAN (5-184): 1.35e-48: 165: 61.96
+	Hs
		266973 SRS10_HUMAN (1-262): 2.41e-34: 126: 100.00		SRSF4_HUMAN (5-265): 3.78e-51: 176: 53.64
+	Hs
		266979 SRS10_HUMAN (1-262): 2.41e-34: 126: 100.00		SRSF9_HUMAN (2-211): 1.47e-52: 172: 33.02
+	Hs
		266981 SRS10_HUMAN (1-262): 2.41e-34: 126: 100.00		SRSF6_HUMAN (5-184): 1.35e-48: 165: 61.96
+	At
		955324 CYP59_ARATH (6-259): 5.13e-31: 121: 19.29		SRS31_ARATH (6-267): 2.4e-48: 162: 27.24
+	At
		186862 CYP59_ARATH (6-259): 5.13e-31: 121: 19.29		SR34_ARATH (6-268): 3.39e-47: 161: 31.90
+	At
		1163069 CYP59_ARATH (6-259): 5.13e-31: 121: 19.29		Q9SPI1_ARATH (6-268): 1.48e-46: 159: 31.80
+	At
		1257937 SL30A_ARATH (9-244): 8.07e-42: 145: 33.48		RSZ33_ARATH (5-80): 2.24e-13: 70.5: 51.32
+	Hs
		266904 SRS10_HUMAN (1-262): 2.41e-34: 126: 100.00		PABP1_HUMAN (98-189): 1.16e-15: 78.6: 18.56
+	Hs
		952060 SRS12_HUMAN (1-251): 1.31e-38: 137: 46.33		SRSF3_HUMAN (4-78): 1.85e-11: 62.8: 47.56
+	Hs
		516744 PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46		PABP1_HUMAN (98-189): 1.16e-15: 78.6: 18.56
+	At
		1163064 CYP59_ARATH (6-259): 5.13e-31: 121: 19.29		RSZ33_ARATH (5-80): 2.24e-13: 70.5: 51.32
+	Hs
		266964 SRS10_HUMAN (1-262): 2.41e-34: 126: 100.00		SRSF3_HUMAN (4-78): 1.85e-11: 62.8: 47.56