Protein: RRS1
Regulator of ribosome biosynthesis

Gene: RRS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 169
UniProt ID: Q08746

Gene Ontology (top 5):
GO:0000055 - ribosomal large subunit export from nucleus
GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0030687 - preribosome, large subunit precursor

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

733965

RPF2
Ribosome biogenesis protein RPF2

11

2

Small-scale

0.980

High

994463

BRX1
Ribosome biogenesis protein BRX1

2

6

Small-scale

0.757

High

731885

EBP2
rRNA-processing protein EBP2

9

1

Small-scale

0.749

High

864700

NOG2
Nucleolar GTP-binding protein 2

7

2

Small-scale

0.737

High

754929

SSF1
Ribosome biogenesis protein SSF1

2

0

High-throughput

0.736

High

755346

RPF1
Ribosome production factor 1

2

0

High-throughput

0.699

High

764267

NOC2
Nucleolar complex protein 2

5

0

Small-scale

0.678

High

973477

NOG1
Nucleolar GTP-binding protein 1

4

1

Small-scale

0.672

High

778881

NOP2
25S rRNA

3

2

Small-scale

0.650

High

860905

PESC
Pescadillo homolog

3

1

High-throughput

0.650

High

866281

NOP15
Ribosome biogenesis protein 15

3

2

High-throughput

0.650

High

996384

MAK21
Ribosome biogenesis protein MAK21

3

4

High-throughput

0.646

High

754216

CIC1
Proteasome-interacting protein CIC1

3

1

High-throughput

0.643

High

992544

NOC3
Nucleolar complex-associated protein 3

3

3

High-throughput

0.643

High

776535

RLP7
Ribosome biogenesis protein RLP7

3

2

Small-scale

0.642

High

638885

SPB4
ATP-dependent rRNA helicase SPB4

3

3

High-throughput

0.633

High

976882

HAS1
ATP-dependent RNA helicase HAS1

3

3

High-throughput

0.633

High

471455

RL11A
Large ribosomal subunit protein uL5A

3

2

Small-scale

0.630

High

996388

RL11B
Large ribosomal subunit protein uL5B

3

2

Small-scale

0.614

High

865771

NOP13
Nucleolar protein 13

2

1

High-throughput

0.601

High

979064

DHR1
Probable ATP-dependent RNA helicase DHR1

2

2

High-throughput

0.601

High

982906

RRP5
rRNA biogenesis protein RRP5

2

2

High-throughput

0.601

High

864514

DBP6
ATP-dependent RNA helicase DBP6

2

2

High-throughput

0.594

High

859987

CGR1
rRNA-processing protein CGR1

2

0

High-throughput

0.588

High

630896

NLE1
Ribosome assembly protein 4

2

1

Small-scale

0.584

High

996381

NOP53
Ribosome biogenesis protein NOP53

2

1

High-throughput

0.584

High

792619

UTP10
U3 small nucleolar RNA-associated protein 10

2

0

High-throughput

0.576

High

703133

MRT4
Ribosome assembly factor MRT4

2

2

High-throughput

0.571

High

757367

FKBP3
Peptidyl-prolyl cis-trans isomerase

2

1

High-throughput

0.571

High

996377

NIP7
60S ribosome subunit biogenesis protein NIP7

2

1

High-throughput

0.571

High

996379

YTM1
Ribosome biogenesis protein YTM1

2

3

High-throughput

0.571

High

811246

MPS3
Spindle pole body assembly component MPS3

1

0

Small-scale

0.568

High

766608

NOP16
Nucleolar protein 16

2

0

High-throughput

0.547

High

977779

ARX1
Probable metalloprotease ARX1

2

0

High-throughput

0.547

High

696424

PP12
Serine/threonine-protein phosphatase PP1-2

1

1

High-throughput

0.536

High

996332

RS10A
Small ribosomal subunit protein eS10A

2

1

High-throughput

0.533

High

399658

RLA0
Large ribosomal subunit protein uL10

2

2

Small-scale

0.521

High

535145

RL3
Large ribosomal subunit protein uL3

2

1

Small-scale

0.521

High

593718

DBP4
ATP-dependent RNA helicase HCA4

1

3

High-throughput

0.515

High

733170

DBP7
ATP-dependent RNA helicase DBP7

1

3

High-throughput

0.515

High

765992

DPO5
rDNA transcriptional regulator POL5

1

1

High-throughput

0.515

High

810940

MTR4
ATP-dependent RNA helicase DOB1

1

1

High-throughput

0.515

High

584813

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.513

High

698738

ORC2
Origin recognition complex subunit 2

1

0

High-throughput

0.493

High

755757

ORC6
Origin recognition complex subunit 6

1

0

High-throughput

0.493

High

860763

UTP22
U3 small nucleolar RNA-associated protein 22

1

0

High-throughput

0.493

High

987102

ESF1
Pre-rRNA-processing protein ESF1

1

0

High-throughput

0.493

High

996376

TCO89
Target of rapamycin complex 1 subunit TCO89

1

0

High-throughput

0.493

High

769683

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.489

High

996272

HRK1
Serine/threonine-protein kinase HRK1

1

1

High-throughput

0.489

High

996382

RTK1
Probable serine/threonine-protein kinase RTK1

1

1

High-throughput

0.489

High

141562

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.479

High

383390

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.479

High

408166

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

413747

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

480359

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

482495

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

594081

MAK11
Protein MAK11

1

3

High-throughput

0.479

High

634462

SPB1
27S pre-rRNA

1

2

High-throughput

0.479

High

634808

KRR1
KRR1 small subunit processome component

1

1

High-throughput

0.479

High

663928

TF3B
Transcription factor IIIB 70 kDa subunit

1

1

High-throughput

0.479

High

699743

DRS1
ATP-dependent RNA helicase DRS1

1

1

High-throughput

0.479

High

700664

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.479

High

715501

RRP1
Ribosomal RNA-processing protein 1

1

1

High-throughput

0.479

High

742083

NOP4
Nucleolar protein 4

1

1

High-throughput

0.479

High

766723

NUG1
Nuclear GTP-binding protein NUG1

1

2

High-throughput

0.479

High

768063

NSA2
Ribosome biogenesis protein NSA2

1

1

High-throughput

0.479

High

865686

IPI3
Pre-rRNA-processing protein IPI3

1

2

High-throughput

0.479

High

866866

RCM1
25S rRNA

1

2

High-throughput

0.479

High

979114

RRB1
Ribosome assembly protein RRB1

1

3

High-throughput

0.479

High

979466

PUF6
Pumilio homology domain family member 6

1

1

High-throughput

0.479

High

979741

UTP14
U3 small nucleolar RNA-associated protein 14

1

1

High-throughput

0.479

High

980173

ERB1
Ribosome biogenesis protein ERB1

1

2

High-throughput

0.479

High

986486

FKBP4
FK506-binding protein 4

1

1

High-throughput

0.479

High

986587

JIP5
WD repeat-containing protein JIP5

1

3

High-throughput

0.479

High

987680

NOC4
Nucleolar complex protein 4

1

4

High-throughput

0.479

High

994058

NOP12
Nucleolar protein 12

1

3

High-throughput

0.479

High

996385

RL7B
Large ribosomal subunit protein uL30B

1

2

High-throughput

0.479

High

615190

BUR1
Serine/threonine-protein kinase BUR1

1

1

High-throughput

0.470

High

819967

PUS4
tRNA pseudouridine synthase 4

1

1

High-throughput

0.470

High

859646

LSG1
Large subunit GTPase 1

1

2

High-throughput

0.470

High

972667

SKI8
Antiviral protein SKI8

1

3

High-throughput

0.470

High

978551

DOT1
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.470

High

986412

YL455
PWWP domain-containing protein YLR455W

1

1

High-throughput

0.470

High

405869

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.458

High

501265

MAK16
Protein MAK16

1

0

High-throughput

0.458

High

635170

YCQ6
Uncharacterized protein YCR016W

1

0

High-throughput

0.458

High

645694

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

688471

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

698190

AFG2
ATPase family gene 2 protein

1

0

High-throughput

0.458

High

732257

RRP14
Ribosomal RNA-processing protein 14

1

0

High-throughput

0.458

High

746277

YBC8
UPF0642 protein YBL028C

1

0

High-throughput

0.458

High

748735

ENP1
Essential nuclear protein 1

1

0

High-throughput

0.458

High

755262

IPI1
Pre-rRNA-processing protein IPI1

1

0

High-throughput

0.458

High

756883

RIX1
Pre-rRNA-processing protein RIX1

1

0

High-throughput

0.458

High

774588

BMT5
25S rRNA

1

0

High-throughput

0.458

High

797410

LOC1
60S ribosomal subunit assembly/export protein LOC1

1

0

High-throughput

0.458

High

810600

ALB1
Ribosome biogenesis protein ALB1

1

0

High-throughput

0.458

High

859526

NSA1
Ribosome biogenesis protein NSA1

1

0

High-throughput

0.458

High

866528

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

978444

RRP17
Ribosomal RNA-processing protein 17

1

0

High-throughput

0.458

High

987650

RRP15
Ribosomal RNA-processing protein 15

1

0

High-throughput

0.458

High

992626

RLP24
Ribosome biogenesis protein RLP24

1

0

High-throughput

0.458

High

993175

BUD20
Bud site selection protein 20

1

0

High-throughput

0.458

High

996378

MDN1
Midasin

1

0

High-throughput

0.458

High

996386

DBP10
ATP-dependent RNA helicase DBP10

1

0

High-throughput

0.458

High

996387

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.458

High

404723

RL7A
Large ribosomal subunit protein uL30A

1

2

High-throughput

0.445

High

960027

SEN1
Helicase SEN1

1

1

Small-scale

0.445

High

750954

RIM11
Serine/threonine-protein kinase RIM11/MSD1

1

1

Small-scale

0.439

High

842052

MRK1
Serine/threonine-protein kinase MRK1

1

1

Small-scale

0.439

High

355678

H2B1
Histone H2B.1

1

1

High-throughput

0.437

High

356039

H2B2
Histone H2B.2

1

1

High-throughput

0.437

High

358295

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.437

High

407371

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.437

High

426189

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.437

High

472434

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

480929

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

481436

RL2A
Large ribosomal subunit protein uL2A

1

1

High-throughput

0.437

High

663549

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

706535

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

743038

GBLP
Small ribosomal subunit protein RACK1

1

3

High-throughput

0.437

High

752710

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.437

High

820217

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.437

High

841447

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.437

High

967806

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.437

High

996383

YRA1
RNA annealing protein YRA1

1

1

Small-scale

0.437

High

406420

RL15A
Large ribosomal subunit protein eL15A

1

1

High-throughput

0.407

High

479041

RL43A
Large ribosomal subunit protein eL43A

1

1

High-throughput

0.407

High

513031

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.407

High

534855

RL30
Large ribosomal subunit protein eL30

1

1

High-throughput

0.407

High

564388

RL8A
Large ribosomal subunit protein eL8A

1

1

High-throughput

0.407

High

829716

RL4B
Large ribosomal subunit protein uL4B

1

1

High-throughput

0.407

High

902115

H3
Histone H3

1

1

High-throughput

0.407

High

641091

RL5
Large ribosomal subunit protein uL18

4

0

Small-scale

0.364

High

864625

BRE5
UBP3-associated protein BRE5

1

0

High-throughput

0.279

Low

964740

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

1

0

High-throughput

0.279

Low

968060

KIN4
Serine/threonine-protein kinase KIN4

1

0

High-throughput

0.279

Low

985926

RGC1
Regulator of the glycerol channel 1

1

0

High-throughput

0.279

Low

549846

UBC4
Ubiquitin-conjugating enzyme E2 4

1

0

High-throughput

0.269

Low

732653

YKC3
Uncharacterized protein YKL023W

1

0

High-throughput

0.269

Low

748063

GDT1
Divalent cation/proton antiporter GDT1

1

0

High-throughput

0.269

Low

753089

OSH3
Oxysterol-binding protein homolog 3

1

0

High-throughput

0.269

Low

755988

YHS7
Uncharacterized protein YHR127W

1

0

High-throughput

0.269

Low

764014

SAW1
Single-strand annealing weakened protein 1

1

0

High-throughput

0.269

Low

766775

BIM1
Protein BIM1

1

0

High-throughput

0.269

Low

797615

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

0

High-throughput

0.269

Low

842772

OCA1
Putative tyrosine-protein phosphatase OCA1

1

0

High-throughput

0.269

Low

978507

RPN9
26S proteasome regulatory subunit RPN9

1

0

High-throughput

0.269

Low

984150

NSE3
Non-structural maintenance of chromosome element 3

1

0

High-throughput

0.269

Low

985805

YL407
Uncharacterized protein YLR407W

1

0

High-throughput

0.269

Low

996380

THP3
Protein THP3

1

0

High-throughput

0.269

Low

996390

SAS5
Something about silencing protein 5

1

0

High-throughput

0.269

Low

516922

SIR4
Regulatory protein SIR4

1

0

Small-scale

0.265

Low

408490

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

0

High-throughput

0.249

Low

471298

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

604633

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

0

High-throughput

0.249

Low

698967

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.249

Low

730156

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

737233

LONM
Lon protease homolog, mitochondrial

1

0

High-throughput

0.249

Low

762629

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

775279

ULP2
Ubiquitin-like-specific protease 2

1

0

High-throughput

0.249

Low

866808

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

991320

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

995818

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

996389

DPH3
Diphthamide biosynthesis protein 3

1

0

Small-scale

0.249

Low

857049

NUP84
Nucleoporin NUP84

1

0

High-throughput

0.238

Low

357737

RL28
Large ribosomal subunit protein uL15

1

0

High-throughput

0.232

Low

368472

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024