HitPredict

Interactor 1: SRS10 (O75494)
Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein)
Gene: SRSF10

Interactor 2: RBM39 (Q14498)
RNA-binding protein 39 (CAPER alpha) (CAPERalpha) (Hepatocellular carcinoma protein 1) (RNA-binding motif protein 39) (RNA-binding region-containing protein 2) (Splicing factor HCC1)
Gene: RBM39

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	28302793
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0016607 - nuclear speck GO:0048024 - regulation of mRNA splicing, via spliceosome GO:0050733 - RS domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 262 Hs			1 530
+	Hs
		1054669 PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46		RBM39_HUMAN (1-530): 2.78e-101: 316: 100.00
+	Hs
		951964 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		RBM39_HUMAN (1-530): 2.78e-101: 316: 100.00
+	Hs
		963985 SRSF2_HUMAN (4-90): 1.89e-24: 99.3: 45.65		RBM39_HUMAN (1-530): 2.78e-101: 316: 100.00
+	Hs
		1031328 PABP4_HUMAN (2-99): 3.59e-20: 91.3: 18.37		RBM39_HUMAN (1-530): 2.78e-101: 316: 100.00
+	Hs
		267093 SRS10_HUMAN (1-262): 2.41e-34: 126: 100.00		PUF60_HUMAN (141-513): 7.12e-66: 225: 19.41
+	Hs
		266904 SRS10_HUMAN (1-262): 2.41e-34: 126: 100.00		PABP1_HUMAN (41-426): 4.09e-61: 214: 19.08
+	Hs
		516744 PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46		PABP1_HUMAN (41-426): 4.09e-61: 214: 19.08
+	Hs
		1031490 PABP4_HUMAN (2-99): 3.59e-20: 91.3: 18.37		PUF60_HUMAN (141-513): 7.12e-66: 225: 19.41
+	Hs
		516466 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		PABP1_HUMAN (41-426): 4.09e-61: 214: 19.08
+	Hs
		516495 PABP4_HUMAN (2-99): 3.59e-20: 91.3: 18.37		PABP1_HUMAN (41-426): 4.09e-61: 214: 19.08
+	Sc
		376562 PABP_YEAST (2-98): 4.25e-20: 91: 24.74		PABP_YEAST (40-441): 6.66e-53: 190: 12.17
+	Hs
		474017 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		PAB4L_HUMAN (247-522): 4e-43: 159: 18.15
+	Hs
		474021 PABP4_HUMAN (2-99): 3.59e-20: 91.3: 18.37		PAB4L_HUMAN (247-522): 4e-43: 159: 18.15
+	Hs
		266976 SRS10_HUMAN (1-262): 2.41e-34: 126: 100.00		ELAV2_HUMAN (434-530): 7.45e-16: 81.1: 10.89
+	Zm
		9810 B4F8E1_MAIZE (5-181): 1.38e-33: 122: 36.16		A0A1D6EZQ5_MAIZE (149-323): 8.87e-17: 85.1: 30.90
+	Hs
		951977 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		SF3B4_HUMAN (238-395): 5.66e-23: 103: 22.79
+	Hs
		1020353 PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46		ELAV2_HUMAN (434-530): 7.45e-16: 81.1: 10.89
+	Hs
		951937 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		ELAV2_HUMAN (434-530): 7.45e-16: 81.1: 10.89
+	Hs
		1020249 PABP4_HUMAN (2-99): 3.59e-20: 91.3: 18.37		ELAV2_HUMAN (434-530): 7.45e-16: 81.1: 10.89
+	Hs
		162035 PABP4_HUMAN (2-99): 3.59e-20: 91.3: 18.37		HNRDL_HUMAN (144-309): 3.62e-15: 79.7: 31.93