HitPredict

Interactor 1: DAB1 (O75553)
Disabled homolog 1
Gene: DAB1

Interactor 2: LDLR (P01130)
Low-density lipoprotein receptor (LDL receptor)
Gene: LDLR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.50	0.542

Property	Details
Experiments	10827173, 9837937
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 588 Hs			1 860
+	Hs
		351073 ARH_HUMAN (1-243): 1.04e-46: 168: 19.69		LDLR_HUMAN (1-860): 0: 697: 100.00
+	Hs
		351065 DAB2_HUMAN (8-587): 2.74e-41: 161: 23.98		LDLR_HUMAN (1-860): 0: 697: 100.00
+	Mm
		956234 DAB1_MOUSE (1-588): 3.86e-74: 249: 91.50		LRP8_MOUSE (3-851): 0: 604: 49.66
+	Hs
		269145 DAB1_HUMAN (1-588): 2.31e-74: 250: 100.00		LRP8_HUMAN (26-851): 0: 565: 45.42
+	Mm
		729617 DAB1_MOUSE (1-588): 3.86e-74: 249: 91.50		LDLR_MOUSE (5-197): 3.55e-17: 88.7: 20.62
+	Hs
		269133 DAB1_HUMAN (1-588): 2.31e-74: 250: 100.00		VLDLR_HUMAN (187-454): 1.14e-15: 83.7: 21.56
+	Mm
		956222 DAB1_MOUSE (1-588): 3.86e-74: 249: 91.50		VLDLR_MOUSE (187-454): 6.02e-15: 81.4: 21.56
+	Hs
		269134 DAB1_HUMAN (1-588): 2.31e-74: 250: 100.00		LRP2_HUMAN (677-844): 3.13e-11: 69.9: 15.48
+	Mm
		69879 DAB1_MOUSE (1-588): 3.86e-74: 249: 91.50		B1AXJ3_MOUSE (3-145): 3.28e-10: 66: 19.88
+	Mm
		57553 DAB1_MOUSE (1-588): 3.86e-74: 249: 91.50		LRP2_MOUSE (232-467): 2.06e-09: 63.7: 18.03
+	Mm
		956233 DAB1_MOUSE (1-588): 3.86e-74: 249: 91.50		LRP1_MOUSE (24-197): 2.28e-09: 63.7: 23.63
+	Hs
		269141 DAB1_HUMAN (1-588): 2.31e-74: 250: 100.00		LRP1_HUMAN (155-417): 9.84e-09: 61.8: 8.73
+	Hs
		992719 GULP1_HUMAN (17-293): 2.72e-60: 204: 21.43		LRP1_HUMAN (155-417): 9.84e-09: 61.8: 8.73
+	Hs
		957621 ANS1B_HUMAN (9-229): 2.08e-44: 171: 17.70		LRP2_HUMAN (677-844): 3.13e-11: 69.9: 15.48
+	Rn
		292326 DAB2_RAT (8-587): 1.42e-43: 168: 22.92		LRP2_RAT (185-425): 4.11e-12: 72.6: 21.79
+	Hs
		957612 ARH_HUMAN (1-243): 1.04e-46: 168: 19.69		LRP2_HUMAN (677-844): 3.13e-11: 69.9: 15.48
+	Hs
		270287 DAB2_HUMAN (8-587): 2.74e-41: 161: 23.98		LRP6_HUMAN (194-374): 7.63e-12: 71.8: 26.60
+	Hs
		992682 ANS1B_HUMAN (9-229): 2.08e-44: 171: 17.70		LRP1_HUMAN (155-417): 9.84e-09: 61.8: 8.73
+	Mm
		57554 DAB2_MOUSE (8-587): 1.14e-43: 168: 23.51		LRP2_MOUSE (232-467): 2.06e-09: 63.7: 18.03
+	Hs
		957165 DAB2_HUMAN (8-587): 2.74e-41: 161: 23.98		LRP2_HUMAN (677-844): 3.13e-11: 69.9: 15.48