Protein: TFEB
Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35)

Gene: TFEB
Organism: Homo sapiens
Interactions: 45
UniProt ID: P19484

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

269090

MITF
Microphthalmia-associated transcription factor

4

13

Small-scale

0.903

High

623614

TFE3
Transcription factor E3

4

13

Small-scale

0.903

High

168933

TFEC
Transcription factor EC

2

13

High-throughput

0.811

High

623613

TFEB
Transcription factor EB

2

13

Small-scale

0.754

High

623619

1433E
14-3-3 protein epsilon

4

8

High-throughput

0.699

High

623616

1433B
14-3-3 protein beta/alpha

3

20

High-throughput

0.662

High

623618

1433G
14-3-3 protein gamma

2

20

High-throughput

0.628

High

623621

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.628

High

623630

RRAGA
Ras-related GTP-binding protein A

1

9

Small-scale

0.618

High

623637

RRAGC
Ras-related GTP-binding protein C

1

9

Small-scale

0.618

High

623615

1433T
14-3-3 protein theta

2

20

Small-scale

0.611

High

623626

TAF9
Transcription initiation factor TFIID subunit 9

2

1

High-throughput

0.611

High

623623

1433F
14-3-3 protein eta

2

20

High-throughput

0.601

High

623635

SRPK1
SRSF protein kinase 1

1

2

High-throughput

0.550

High

488152

IFIT1
Antiviral innate immune response effector IFIT1

1

3

High-throughput

0.536

High

529051

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.536

High

623638

EMAL4
Echinoderm microtubule-associated protein-like 4

1

2

High-throughput

0.536

High

623639

TBC14
TBC1 domain family member 14

1

2

High-throughput

0.536

High

563168

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.518

High

187003

PPM1G
Protein phosphatase 1G

1

0

High-throughput

0.513

High

346845

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.513

High

623617

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

1

High-throughput

0.489

High

623632

PGAM4
Probable phosphoglycerate mutase 4

1

1

High-throughput

0.489

High

172462

XPO1
Exportin-1

1

7

High-throughput

0.479

High

334334

TRI16
Tripartite motif-containing protein 16

1

3

Small-scale

0.479

High

456602

ANXA2
Annexin A2

1

2

Small-scale

0.479

High

593811

PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

1

8

Small-scale

0.479

High

623620

H4
Histone H4

1

11

High-throughput

0.479

High

623622

SUMO1
Small ubiquitin-related modifier 1

1

3

Small-scale

0.479

High

623624

FOXO1
Forkhead box protein O1

1

4

High-throughput

0.479

High

623627

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.479

High

623641

CHIP
E3 ubiquitin-protein ligase CHIP

1

2

Small-scale

0.479

High

623642

HDAC5
Histone deacetylase 5

1

11

Small-scale

0.479

High

623633

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

623640

FBXL5
F-box/LRR-repeat protein 5

1

0

Small-scale

0.458

High

623629

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

8

High-throughput

0.445

High

623628

FBX42
F-box only protein 42

1

3

High-throughput

0.437

High

623631

FABD
Malonyl-CoA-acyl carrier protein transacylase, mitochondrial

1

2

High-throughput

0.437

High

623634

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.426

High

623643

KAD6
Adenylate kinase isoenzyme 6

1

0

High-throughput

0.426

High

360373

COX2
Cytochrome c oxidase subunit 2

1

1

High-throughput

0.407

High

617468

ATP5J
ATP synthase peripheral stalk subunit F6, mitochondrial

1

0

High-throughput

0.279

Low

623625

GPNMB
Transmembrane glycoprotein NMB

1

0

High-throughput

0.279

Low

623636

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025