Interactor 1: LRP6 (O75581)
Low-density lipoprotein receptor-related protein 6 (LRP-6)
Gene: LRP6

Interactor 2: FZD8 (Q9H461)
Frizzled-8 (Fz-8) (hFz8)
Gene: FZD8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.58 0.60 0.595

The method score is based on:

Property Details
Experiments 15908424, 11448771
Identification Methods affinity chromatography technology, pull down
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005102 - signaling receptor binding
GO:0005886 - plasma membrane
GO:0017147 - Wnt-protein binding
GO:0042813 - Wnt receptor activity
GO:0060070 - canonical Wnt signaling pathway
and 1 others

more...

Homologous interactions 4

Homologous interactions

Color coding for hit scores

1 1613
Hs

1 694
+ Hs
+ Hs
+ Dm
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024