HitPredict

Interactor 1: KS6A5 (O75582)
Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL)
Gene: RPS6KA5

Interactor 2: HS904 (Q58FG1)
Putative heat shock protein HSP 90-alpha A4 (Heat shock 90 kDa protein 1 alpha-like 2) (Heat shock protein 90-alpha D) (Heat shock protein 90Ad)
Gene: HSP90AA4P

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	28514442
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 802 Hs			1 418
+	Hs
		272878 KS6A4_HUMAN (18-786): 0: 727: 59.38		HS904_HUMAN (1-418): 0: 547: 100.00
+	Hs
		270363 KS6A5_HUMAN (17-802): 0: 825: 100.00		HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41
+	Hs
		270364 KS6A5_HUMAN (17-802): 0: 825: 100.00		HS90B_HUMAN (96-256): 4.57e-41: 156: 51.85
+	Hs
		1073431 KS6A1_HUMAN (4-752): 0: 714: 40.27		H90B2_HUMAN (2-304): 8.06e-80: 252: 34.81
+	Hs
		272843 KS6A4_HUMAN (18-786): 0: 727: 59.38		HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41
+	Hs
		272844 KS6A4_HUMAN (18-786): 0: 727: 59.38		HS90B_HUMAN (96-256): 4.57e-41: 156: 51.85
+	Hs
		431876 KS6A1_HUMAN (4-752): 0: 714: 40.27		HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41
+	Hs
		438193 KS6A1_HUMAN (4-752): 0: 714: 40.27		HS90B_HUMAN (96-256): 4.57e-41: 156: 51.85
+	Hs
		432343 KS6A6_HUMAN (3-752): 0: 688: 39.55		HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41
+	Hs
		438601 KS6A6_HUMAN (3-752): 0: 688: 39.55		HS90B_HUMAN (96-256): 4.57e-41: 156: 51.85
+	Hs
		272876 KS6A4_HUMAN (18-786): 0: 727: 59.38		H90B4_HUMAN (112-275): 1.78e-26: 112: 42.42
+	Hs
		850666 KS6A3_HUMAN (366-776): 2.03e-107: 347: 23.47		H90B2_HUMAN (2-304): 8.06e-80: 252: 34.81
+	Hs
		431672 KS6A3_HUMAN (366-776): 2.03e-107: 347: 23.47		HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41
+	Hs
		431873 KS6A2_HUMAN (423-760): 1.49e-107: 347: 25.78		HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41
+	Hs
		438011 KS6A3_HUMAN (366-776): 2.03e-107: 347: 23.47		HS90B_HUMAN (96-256): 4.57e-41: 156: 51.85
+	Hs
		438190 KS6A2_HUMAN (423-760): 1.49e-107: 347: 25.78		HS90B_HUMAN (96-256): 4.57e-41: 156: 51.85
+	Hs
		431573 AKT2_HUMAN (365-708): 1.8e-103: 329: 29.36		HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41
+	Hs
		432376 AKT3_HUMAN (384-708): 4.16e-100: 320: 28.45		HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41
+	Hs
		437928 AKT2_HUMAN (365-708): 1.8e-103: 329: 29.36		HS90B_HUMAN (96-256): 4.57e-41: 156: 51.85
+	Bt
		964601 AKT1_BOVIN (383-708): 3.86e-100: 320: 27.99		HS90B_BOVIN (96-256): 4.94e-41: 156: 51.85