Protein: FZD7
Frizzled-7 (Fz-7) (hFz7) (FzE3)

Gene: FZD7
Organism: Homo sapiens
Interactions: 87
UniProt ID: O75084

Gene Ontology (top 5):
GO:0004930 - G protein-coupled receptor activity
GO:0005109 - frizzled binding
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding
GO:0005886 - plasma membrane
GO:0006355 - regulation of DNA-templated transcription

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

270439

WNT3
Proto-oncogene Wnt-3

2

20

Small-scale

0.754

High

159299

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

20

Small-scale

0.724

High

270492

UBQL1
Ubiquilin-1

4

4

High-throughput

0.692

High

270455

FZD2
Frizzled-2

1

12

High-throughput

0.691

High

270440

WNT3A
Protein Wnt-3a

1

20

Small-scale

0.652

High

270428

LAMP1
Lysosome-associated membrane glycoprotein 1

2

1

High-throughput

0.628

High

270448

AT2B2
Plasma membrane calcium-transporting ATPase 2

2

4

High-throughput

0.628

High

270459

S39A4
Zinc transporter ZIP4

2

5

High-throughput

0.628

High

270436

WNT5A
Protein Wnt-5a

1

20

Small-scale

0.625

High

270444

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

2

High-throughput

0.621

High

270425

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

2

Small-scale

0.618

High

194658

FFAR2
Free fatty acid receptor 2

2

2

High-throughput

0.606

High

213670

AQP9
Aquaporin-9

2

2

High-throughput

0.606

High

226637

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

2

1

High-throughput

0.606

High

270435

HPCL1
Hippocalcin-like protein 1

2

2

High-throughput

0.606

High

270443

NCS1
Neuronal calcium sensor 1

2

2

High-throughput

0.606

High

270472

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

2

1

High-throughput

0.606

High

270488

UBQL2
Ubiquilin-2

2

4

High-throughput

0.606

High

166226

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

2

0

High-throughput

0.580

High

270426

MGST1
Microsomal glutathione S-transferase 1

2

0

High-throughput

0.580

High

270474

TM237
Transmembrane protein 237

2

0

High-throughput

0.580

High

270476

B2L13
Bcl-2-like protein 13

2

0

High-throughput

0.580

High

140078

SDCB1
Syntenin-1

1

19

Small-scale

0.578

High

270449

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

7

Small-scale

0.575

High

270450

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

5

Small-scale

0.575

High

270491

FZD10
Frizzled-10

1

10

High-throughput

0.575

High

270486

DAPLE
Protein Daple

1

2

Small-scale

0.561

High

71827

LEUTX
Paired-like homeodomain transcription factor LEUTX

2

1

High-throughput

0.553

High

270442

NCALD
Neurocalcin-delta

2

2

High-throughput

0.553

High

270445

DLG4
Disks large homolog 4

1

13

Small-scale

0.552

High

270446

S35B1
Solute carrier family 35 member B1

1

1

High-throughput

0.541

High

132540

UPK1A
Uroplakin-1a

1

9

High-throughput

0.536

High

186391

TM9S1
Transmembrane 9 superfamily member 1

1

1

High-throughput

0.536

High

270420

VNN2
Pantetheine hydrolase VNN2

1

3

High-throughput

0.536

High

270430

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

5

High-throughput

0.536

High

270432

FGFR4
Fibroblast growth factor receptor 4

1

5

High-throughput

0.536

High

270433

AT2B4
Plasma membrane calcium-transporting ATPase 4

1

5

High-throughput

0.536

High

270438

AGRE5
Adhesion G protein-coupled receptor E5

1

6

High-throughput

0.536

High

270457

ZACN
Ligand-gated cation channel ZACN

1

6

High-throughput

0.536

High

270460

SE6L2
Seizure 6-like protein 2

1

5

High-throughput

0.536

High

270462

NFXL1
NF-X1-type zinc finger protein NFXL1

1

2

High-throughput

0.536

High

270464

AGRG6
Adhesion G-protein coupled receptor G6

1

6

High-throughput

0.536

High

270465

O13J1
Olfactory receptor 13J1

1

5

High-throughput

0.536

High

270466

GOGA5
Golgin subfamily A member 5

1

1

High-throughput

0.536

High

270469

TM9S4
Transmembrane 9 superfamily member 4

1

1

High-throughput

0.536

High

270470

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

1

High-throughput

0.536

High

270473

CERS2
Ceramide synthase 2

1

3

High-throughput

0.536

High

270480

TTYH1
Protein tweety homolog 1

1

2

High-throughput

0.536

High

270485

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

1

High-throughput

0.536

High

104934

APRIO
Alternative prion protein

1

2

High-throughput

0.523

High

270421

CLPT1
Putative lipid scramblase CLPTM1

1

0

High-throughput

0.518

High

270451

ADCY1
Adenylate cyclase type 1

1

0

High-throughput

0.518

High

270454

HAP28
28 kDa heat- and acid-stable phosphoprotein

1

0

High-throughput

0.518

High

270477

PIP30
PSME3-interacting protein

1

0

High-throughput

0.518

High

270484

AIG1
Androgen-induced gene 1 protein

1

0

High-throughput

0.518

High

270487

CLN8
Protein CLN8

1

0

High-throughput

0.518

High

270479

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

1

2

High-throughput

0.515

High

270481

S39A2
Zinc transporter ZIP2

1

5

High-throughput

0.515

High

161175

EI24
Etoposide-induced protein 2.4 homolog

1

0

High-throughput

0.513

High

270427

PPAL
Lysosomal acid phosphatase

1

0

High-throughput

0.513

High

270429

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

High-throughput

0.513

High

270456

MSMO1
Methylsterol monooxygenase 1

1

0

High-throughput

0.513

High

270471

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

0

High-throughput

0.513

High

270475

SGMR1
Sigma non-opioid intracellular receptor 1

1

0

High-throughput

0.513

High

270483

UBQL4
Ubiquilin-4

1

4

High-throughput

0.494

High

270452

TRAF2
TNF receptor-associated factor 2

1

3

High-throughput

0.489

High

270458

TRI68
E3 ubiquitin-protein ligase TRIM68

1

1

High-throughput

0.489

High

270467

SG1C1
Secretoglobin family 1C member 1

1

2

High-throughput

0.489

High

270482

TMM9B
Transmembrane protein 9B

1

1

High-throughput

0.489

High

270419

LRP6
Low-density lipoprotein receptor-related protein 6

1

5

Small-scale

0.484

High

270423

PRIO
Major prion protein

1

0

High-throughput

0.484

High

270422

EGFR
Epidermal growth factor receptor

1

5

High-throughput

0.479

High

270424

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

5

High-throughput

0.479

High

270434

BASI
Basigin

1

4

High-throughput

0.479

High

270490

ZNRF3
E3 ubiquitin-protein ligase ZNRF3

1

6

Small-scale

0.479

High

270493

EPN1
Epsin-1

1

1

Small-scale

0.479

High

270461

RSPO2
R-spondin-2

1

0

Small-scale

0.458

High

270489

VATH
V-type proton ATPase subunit H

1

0

High-throughput

0.458

High

270437

OR1D4
Olfactory receptor 1D4

1

5

High-throughput

0.445

High

270453

TRDN
Triadin

1

3

High-throughput

0.445

High

270447

ALEX
Protein ALEX

1

0

High-throughput

0.438

High

270463

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

65212

TIKI2
Metalloprotease TIKI2

1

0

Small-scale

0.426

High

270441

SYJ2B
Synaptojanin-2-binding protein

1

16

High-throughput

0.407

High

270431

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

0

High-throughput

0.279

Low

270468

BRI3B
BRI3-binding protein

1

0

High-throughput

0.279

Low

270478

SHRPN
Sharpin

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025