Protein: SFRP4
Secreted frizzled-related protein 4 (sFRP-4) (Frizzled protein, human endometrium) (FrpHE)

Gene: SFRP4
Organism: Homo sapiens
Interactions: 53
UniProt ID: Q6FHJ7

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0002092 - positive regulation of receptor internalization
GO:0005615 - extracellular space
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

274162

ANR17
Ankyrin repeat domain-containing protein 17

3

1

High-throughput

0.861

High

1232367

ANKH1
Ankyrin repeat and KH domain-containing protein 1

3

1

High-throughput

0.861

High

1054187

P2R3A
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha

3

0

High-throughput

0.638

High

1232375

SIR1
NAD-dependent protein deacetylase sirtuin-1

3

0

High-throughput

0.638

High

1232381

TBB1
Tubulin beta-1 chain

3

0

High-throughput

0.638

High

697916

CALR
Calreticulin

2

2

High-throughput

0.628

High

683474

IKBA
NF-kappa-B inhibitor alpha

1

2

Small-scale

0.618

High

1232378

PASK
PAS domain-containing serine/threonine-protein kinase

2

1

High-throughput

0.611

High

1232385

AKA11
A-kinase anchor protein 11

2

0

High-throughput

0.585

High

1232369

DHB11
Estradiol 17-beta-dehydrogenase 11

2

0

High-throughput

0.580

High

1108922

AQP6
Aquaporin-6

2

1

High-throughput

0.553

High

224130

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

1

3

High-throughput

0.541

High

410901

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

5

High-throughput

0.541

High

467924

PFKAM
ATP-dependent 6-phosphofructokinase, muscle type

1

1

High-throughput

0.541

High

764372

CTNA1
Catenin alpha-1

1

1

High-throughput

0.541

High

787181

BMR1A
Bone morphogenetic protein receptor type-1A

1

2

High-throughput

0.541

High

928694

PMS2
Mismatch repair endonuclease PMS2

1

1

High-throughput

0.541

High

1050801

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

2

High-throughput

0.541

High

1090061

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

1

High-throughput

0.541

High

1106578

SMAD4
Mothers against decapentaplegic homolog 4

1

2

High-throughput

0.541

High

1215309

DCAF8
DDB1- and CUL4-associated factor 8

1

1

High-throughput

0.536

High

170197

AURKA
Aurora kinase A

1

0

High-throughput

0.518

High

659509

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.518

High

839035

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

0

High-throughput

0.518

High

1232374

AP2M1
AP-2 complex subunit mu

1

0

High-throughput

0.518

High

1232377

RHG07
Rho GTPase-activating protein 7

1

0

High-throughput

0.518

High

1162986

H2B2E
Histone H2B type 2-E

1

1

High-throughput

0.515

High

156291

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

1

0

High-throughput

0.513

High

373995

RASN
GTPase NRas

1

1

High-throughput

0.494

High

1144246

PGFRL
Platelet-derived growth factor receptor-like protein

1

6

High-throughput

0.494

High

842787

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

1

High-throughput

0.481

High

654516

FBLN1
Fibulin-1

1

2

High-throughput

0.479

High

1231820

H2B2C
Putative histone H2B type 2-C

1

1

High-throughput

0.479

High

1232376

DCAF5
DDB1- and CUL4-associated factor 5

1

1

High-throughput

0.479

High

791460

SYUA
Alpha-synuclein

1

0

High-throughput

0.460

High

1232372

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

0

High-throughput

0.458

High

1232380

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

1232386

DICER
Endoribonuclease Dicer

1

0

High-throughput

0.458

High

1232387

FBW1A
F-box/WD repeat-containing protein 1A

1

0

Small-scale

0.458

High

1232366

SAMD1
Sterile alpha motif domain-containing protein 1

1

1

High-throughput

0.445

High

1232368

ARF
Tumor suppressor ARF

1

0

High-throughput

0.438

High

772318

FBN2
Fibrillin-2 [Cleaved into: Placensin]

1

1

High-throughput

0.437

High

1232383

LRP1B
Low-density lipoprotein receptor-related protein 1B

1

5

High-throughput

0.437

High

1232365

ATAD2
ATPase family AAA domain-containing protein 2

1

0

High-throughput

0.426

High

1232379

UCK2
Uridine-cytidine kinase 2

1

0

High-throughput

0.426

High

725402

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

3

0

High-throughput

0.347

High

1232382

DCA16
DDB1- and CUL4-associated factor 16

3

0

High-throughput

0.347

High

1232370

B3GL2
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2

2

0

High-throughput

0.318

High

553832

KCRU
Creatine kinase U-type, mitochondrial

1

0

High-throughput

0.282

High

1232384

NARF
Nuclear prelamin A recognition factor

1

0

High-throughput

0.282

High

1232373

JPH3
Junctophilin-3

1

0

High-throughput

0.268

Low

1232371

RASF8
Ras association domain-containing protein 8

1

0

High-throughput

0.249

Low

702127

ITPI2
Protein ITPRID2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025