HitPredict

Interactor 1: MED6 (O75586)
Mediator of RNA polymerase II transcription subunit 6 (Activator-recruited cofactor 33 kDa component) (ARC33) (Mediator complex subunit 6) (hMed6) (Renal carcinoma antigen NY-REN-28)
Gene: MED6

Interactor 2: CDK19 (Q9BWU1)
Cyclin-dependent kinase 19 (EC 2.7.11.22) (CDC2-related protein kinase 6) (Cell division cycle 2-like protein kinase 6) (Cell division protein kinase 19) (Cyclin-dependent kinase 11) (Death-preventing kinase)
Gene: CDK19

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.947

Property	Details
Experiments	24981860, 26186194, 28514442, 33961781, 32707033, 23602568
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Med6~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 246 Hs			1 502
+	Hs
		270486 MED6_HUMAN (1-246): 1.59e-147: 413: 100.00		CDK8_HUMAN (1-502): 1.77e-150: 439: 76.69
+	Hs
		73024 MED6_HUMAN (1-246): 1.59e-147: 413: 100.00		B4DUB1_HUMAN (152-502): 1.59e-138: 406: 100.00
+	Dm
		1229242 MED6_DROME (1-244): 3.59e-121: 346: 44.88		CDK8_DROME (1-413): 7.19e-138: 407: 77.24
+	Sc
		754273 MED6_YEAST (13-150): 3.93e-46: 157: 27.14		SSN3_YEAST (41-376): 4.15e-75: 248: 43.64