Protein: TOP3A
DNA topoisomerase 3-alpha (EC 5.6.2.1) (DNA topoisomerase III alpha)

Gene: TOP3A
Organism: Homo sapiens
Interactions: 90
UniProt ID: Q13472

Gene Ontology (top 5):
GO:0000724 - double-strand break repair via homologous recombination
GO:0003677 - DNA binding
GO:0003697 - single-stranded DNA binding
GO:0003917 - DNA topoisomerase type I (single strand cut, ATP-independent) activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

867585

BLM
RecQ-like DNA helicase BLM

13

11

Small-scale

0.983

High

1035358

RMI1
RecQ-mediated genome instability protein 1

10

5

Small-scale

0.975

High

1035338

FANCM
Fanconi anemia group M protein

3

6

Small-scale

0.857

High

1035355

TDRD3
Tudor domain-containing protein 3

1

4

Small-scale

0.710

High

1035342

RMI2
RecQ-mediated genome instability protein 2

5

0

Small-scale

0.687

High

176596

FANCA
Fanconi anemia group A protein

5

0

Small-scale

0.676

High

552655

RFA2
Replication protein A 32 kDa subunit

3

1

Small-scale

0.656

High

651129

RFA1
Replication protein A 70 kDa DNA-binding subunit

3

1

Small-scale

0.656

High

848025

MECP2
Methyl-CpG-binding protein 2

2

1

High-throughput

0.628

High

295529

RECQ5
ATP-dependent DNA helicase Q5

1

10

Small-scale

0.618

High

720391

RFA3
Replication protein A 14 kDa subunit

2

1

Small-scale

0.611

High

836723

DNLI3
DNA ligase 3

2

1

High-throughput

0.611

High

1035336

ECHD2
Enoyl-CoA hydratase domain-containing protein 2, mitochondrial

3

1

High-throughput

0.609

High

602093

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

2

0

High-throughput

0.602

High

671067

ATPD
ATP synthase subunit delta, mitochondrial

2

0

High-throughput

0.602

High

885858

YBEY
Endoribonuclease YbeY

2

0

High-throughput

0.602

High

1035325

THEM4
Acyl-coenzyme A thioesterase THEM4

2

0

High-throughput

0.602

High

1035335

NIT1
Deaminated glutathione amidase

2

0

High-throughput

0.602

High

1035346

SLX1
Structure-specific endonuclease subunit SLX1

2

0

High-throughput

0.602

High

1035350

TMM70
Transmembrane protein 70, mitochondrial

2

0

High-throughput

0.602

High

63139

CCD69
Coiled-coil domain-containing protein 69

2

0

High-throughput

0.585

High

1035332

RM21
Large ribosomal subunit protein bL21m

2

1

High-throughput

0.574

High

386677

P53
Cellular tumor antigen p53

2

3

Small-scale

0.571

High

1035326

CE162
Centrosomal protein of 162 kDa

2

1

High-throughput

0.571

High

1035339

CENPS
Centromere protein S

2

0

Small-scale

0.559

High

1035345

TSNAX
Translin-associated protein X

1

1

Small-scale

0.552

High

518989

PIP
Prolactin-inducible protein

1

1

High-throughput

0.536

High

1035320

H2B2E
Histone H2B type 2-E

1

2

High-throughput

0.536

High

1035347

LSMD1
N-alpha-acetyltransferase 38, NatC auxiliary subunit

1

2

High-throughput

0.536

High

1035349

FEM1A
Protein fem-1 homolog A

1

1

High-throughput

0.536

High

1035315

SPIDR
DNA repair-scaffolding protein

1

0

Small-scale

0.530

High

612478

XPA
DNA repair protein complementing XP-A cells

1

0

High-throughput

0.513

High

857465

HMGA2
High mobility group protein HMGI-C

1

0

High-throughput

0.513

High

1035343

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.513

High

1035354

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.513

High

1035360

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

0

High-throughput

0.513

High

1035361

RT18B
Small ribosomal subunit protein mS40

1

0

High-throughput

0.513

High

1035318

TERF2
Telomeric repeat-binding factor 2

1

0

Small-scale

0.493

High

1035328

RIF1
Telomere-associated protein RIF1

1

1

Small-scale

0.484

High

326626

SNAI1
Zinc finger protein SNAI1

1

1

High-throughput

0.479

High

440502

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.479

High

455403

PARP1
Poly [ADP-ribose] polymerase 1

1

6

High-throughput

0.479

High

749462

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

803110

IF2M
Translation initiation factor IF-2, mitochondrial

1

1

High-throughput

0.479

High

981232

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

3

High-throughput

0.479

High

1029384

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.479

High

1035314

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1035324

SYAM
Alanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

1035331

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

1035333

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

1035337

MIB1
E3 ubiquitin-protein ligase MIB1

1

2

Small-scale

0.479

High

1035352

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

174392

FANCG
Fanconi anemia group G protein

1

0

Small-scale

0.458

High

224423

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.458

High

319823

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

Small-scale

0.458

High

569691

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

590898

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

799220

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

917221

H4
Histone H4

1

0

High-throughput

0.458

High

1012584

FP100
Fanconi anemia core complex-associated protein 100

1

0

Small-scale

0.458

High

1035329

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

1035330

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

1035340

HROB
Homologous recombination OB-fold protein

1

0

Small-scale

0.458

High

1035356

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1035359

ETAA1
Ewing's tumor-associated antigen 1

1

0

Small-scale

0.458

High

496970

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.445

High

861737

PLK1
Serine/threonine-protein kinase PLK1

1

1

High-throughput

0.445

High

1035322

ERC6L
DNA excision repair protein ERCC-6-like

1

1

High-throughput

0.445

High

1035353

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1035334

SHLD2
Shieldin complex subunit 2

1

0

Small-scale

0.426

High

1035323

OXLD1
Oxidoreductase-like domain-containing protein 1

3

0

High-throughput

0.347

High

326313

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

2

0

High-throughput

0.328

High

537205

CX7A2
Cytochrome c oxidase subunit 7A2, mitochondrial

2

0

High-throughput

0.328

High

823256

MRP
MARCKS-related protein

2

0

High-throughput

0.328

High

1035321

ODAPH
Odontogenesis associated phosphoprotein

2

0

High-throughput

0.328

High

1035344

MET2A
tRNA N(3)-methylcytidine methyltransferase METTL2A

2

0

High-throughput

0.328

High

182978

GR6
Protein GR6

1

0

High-throughput

0.279

Low

495703

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

0

High-throughput

0.279

Low

815363

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.279

Low

879881

NDUV3
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

1

0

High-throughput

0.279

Low

1035316

MAP7
Ensconsin

1

0

High-throughput

0.279

Low

1035317

ICAM4
Intercellular adhesion molecule 4

1

0

High-throughput

0.279

Low

1035319

RM23
Large ribosomal subunit protein uL23m

1

0

High-throughput

0.279

Low

1035327

ATPF1
ATP synthase mitochondrial F1 complex assembly factor 1

1

0

High-throughput

0.279

Low

1035341

SRB4D
Scavenger receptor cysteine-rich domain-containing group B protein

1

0

High-throughput

0.279

Low

1035351

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.279

Low

270033

RF1M
Peptide chain release factor 1, mitochondrial

1

0

High-throughput

0.249

Low

384790

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

1035348

TMM79
Transmembrane protein 79

1

0

Small-scale

0.249

Low

1035357

Q9H8E5
cDNA FLJ13705 fis, clone PLACE2000302

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024