Protein: MBD1
Methyl-CpG-binding domain protein 1 (CXXC-type zinc finger protein 3) (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1)

Gene: MBD1
Organism: Homo sapiens
Interactions: 81
UniProt ID: Q9UIS9

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005694 - chromosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1139865

SETB1
Histone-lysine N-methyltransferase SETDB1

2

16

Small-scale

0.830

High

188384

HDAC3
Histone deacetylase 3

1

20

Small-scale

0.730

High

1094750

CAF1A
Chromatin assembly factor 1 subunit A

3

4

Small-scale

0.686

High

1250475

MCAF1
Activating transcription factor 7-interacting protein 1

3

7

Small-scale

0.672

High

853433

CBX5
Chromobox protein homolog 5

3

20

Small-scale

0.671

High

1110162

HDAC1
Histone deacetylase 1

1

20

Small-scale

0.665

High

1368191

HDAC2
Histone deacetylase 2

1

20

Small-scale

0.665

High

297709

PIAS1
E3 SUMO-protein ligase PIAS1

2

2

Small-scale

0.639

High

216558

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

6

Small-scale

0.578

High

397169

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

129823

CBX4
E3 SUMO-protein ligase CBX4

1

20

Small-scale

0.561

High

1404825

RING2
E3 ubiquitin-protein ligase RING2

1

20

Small-scale

0.561

High

1330971

CGAS
Cyclic GMP-AMP synthase

2

0

Small-scale

0.559

High

844068

HD
Huntingtin

1

0

High-throughput

0.543

High

688183

EF1G
Elongation factor 1-gamma

1

1

High-throughput

0.541

High

857581

NOTC1
Neurogenic locus notch homolog protein 1

1

4

High-throughput

0.541

High

1058348

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.541

High

1460485

NOTC3
Neurogenic locus notch homolog protein 3

1

4

High-throughput

0.541

High

166204

AIM2
Interferon-inducible protein AIM2

1

4

High-throughput

0.536

High

331395

KI20A
Kinesin-like protein KIF20A

1

4

High-throughput

0.536

High

487862

PARP1
Poly [ADP-ribose] polymerase 1

1

10

High-throughput

0.536

High

1054813

SUH
Recombining binding protein suppressor of hairless

1

5

High-throughput

0.536

High

1235563

IFIX
Pyrin and HIN domain-containing protein 1

1

4

High-throughput

0.536

High

1406274

KIF2C
Kinesin-like protein KIF2C

1

4

High-throughput

0.536

High

1404108

NELL2
Protein kinase C-binding protein NELL2

1

7

High-throughput

0.532

High

1460487

PIAS3
E3 SUMO-protein ligase PIAS3

1

2

Small-scale

0.529

High

297879

PIAS2
E3 SUMO-protein ligase PIAS2

1

2

Small-scale

0.527

High

158350

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.518

High

1106777

SNPC2
snRNA-activating protein complex subunit 2

1

0

High-throughput

0.518

High

1353697

ZN384
Zinc finger protein 384

1

0

High-throughput

0.518

High

1407125

MDFI
MyoD family inhibitor

1

0

High-throughput

0.518

High

838195

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

2

Small-scale

0.515

High

991456

SUMO1
Small ubiquitin-related modifier 1

1

1

Small-scale

0.515

High

423414

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

465052

SP1
Transcription factor Sp1

1

9

Small-scale

0.501

High

1217074

MCAF2
Activating transcription factor 7-interacting protein 2

1

1

Small-scale

0.501

High

1143712

Q15156
Protein PML

1

20

Small-scale

0.500

High

270528

MEGF6
Multiple epidermal growth factor-like domains protein 6

1

5

High-throughput

0.494

High

666733

TENA
Tenascin

1

3

High-throughput

0.494

High

943627

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

3

High-throughput

0.494

High

1092509

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

1

High-throughput

0.494

High

1324545

LTBP4
Latent-transforming growth factor beta-binding protein 4

1

6

High-throughput

0.494

High

1369248

NELL1
Protein kinase C-binding protein NELL1

1

7

High-throughput

0.494

High

1371470

DVL3
Segment polarity protein dishevelled homolog DVL-3

1

3

High-throughput

0.494

High

1395363

CC136
Coiled-coil domain-containing protein 136

1

3

High-throughput

0.494

High

1449058

LTBP3
Latent-transforming growth factor beta-binding protein 3

1

6

High-throughput

0.494

High

1460486

JAG2
Protein jagged-2

1

5

High-throughput

0.494

High

505623

ATX1L
Ataxin-1-like

1

2

High-throughput

0.481

High

1396147

Z512B
Zinc finger protein 512B

1

10

High-throughput

0.481

High

1436539

ECT2
Protein ECT2

1

4

High-throughput

0.481

High

1460484

TEN1
Teneurin-1

1

6

Small-scale

0.481

High

180956

TIF1A
Transcription intermediary factor 1-alpha

1

18

High-throughput

0.479

High

373437

MYC
Myc proto-oncogene protein

1

11

Small-scale

0.479

High

385191

K1C14
Keratin, type I cytoskeletal 14

1

5

Small-scale

0.479

High

424282

S10A8
Protein S100-A8

1

4

Small-scale

0.479

High

520643

RARA
Retinoic acid receptor alpha

1

20

Small-scale

0.479

High

551324

PCNA
Proliferating cell nuclear antigen

1

4

Small-scale

0.479

High

883728

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.479

High

888378

MCM2
DNA replication licensing factor MCM2

1

6

High-throughput

0.479

High

966989

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

980505

H4
Histone H4

1

10

High-throughput

0.479

High

998923

H31
Histone H3.1

1

20

Small-scale

0.479

High

1045884

TF65
Transcription factor p65

1

9

High-throughput

0.479

High

1142005

EEA1
Early endosome antigen 1

1

5

High-throughput

0.479

High

1290799

ZCH18
Zinc finger CCCH domain-containing protein 18

1

6

High-throughput

0.479

High

1380238

FBXW7
F-box/WD repeat-containing protein 7

1

9

High-throughput

0.479

High

1401434

CIC
Protein capicua homolog

1

16

High-throughput

0.479

High

1459229

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1288939

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

1

High-throughput

0.445

High

1400903

PRAM
PML-RARA-regulated adapter molecule 1

1

8

Small-scale

0.437

High

1434176

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

1119349

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

62713

A4QMR6
LOC161527 protein

1

1

High-throughput

0.417

High

705600

GRN
Progranulin

1

0

High-throughput

0.282

High

1024487

S25A3
Solute carrier family 25 member 3

1

0

High-throughput

0.282

High

1362091

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

1

0

High-throughput

0.282

High

611580

LOX12
Polyunsaturated fatty acid lipoxygenase ALOX12

1

0

Small-scale

0.249

Low

761100

GBRA3
Gamma-aminobutyric acid receptor subunit alpha-3

1

0

High-throughput

0.249

Low

1253009

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.249

Low

505399

CC159
Coiled-coil domain-containing protein 159

1

0

High-throughput

0.238

Low

255268

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025