HitPredict

Interactor 1: DEDD (O75618)
Death effector domain-containing protein (DEDPro1) (Death effector domain-containing testicular molecule) (FLDED-1)
Gene: DEDD

Interactor 2: FADD (Q13158)
FAS-associated death domain protein (FAS-associating death domain-containing protein) (Growth-inhibiting gene 3 protein) (Mediator of receptor induced toxicity)
Gene: FADD

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.857

Property	Details
Experiments	11741985, 9774341, 17193921
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	DED~DED
Common GO terms	GO:0005737 - cytoplasm GO:0008625 - extrinsic apoptotic signaling pathway via death domain receptors
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 318 Hs			1 208
+	Hs
		271700 DEDD_HUMAN (1-318): 0: 576: 100.00		CASP8_HUMAN (1-206): 3.43e-55: 184: 20.35
+	Hs
		271707 DEDD_HUMAN (1-318): 0: 576: 100.00		CASPA_HUMAN (4-206): 3.44e-48: 166: 19.12
+	Hs
		181575 DEDD_HUMAN (1-318): 0: 576: 100.00		CFLAR_HUMAN (6-193): 3.97e-39: 141: 16.67
+	Hs
		1059331 DEDD2_HUMAN (12-309): 1.92e-129: 373: 43.93		CASP8_HUMAN (1-206): 3.43e-55: 184: 20.35
+	Hs
		1263648 DEDD2_HUMAN (12-309): 1.92e-129: 373: 43.93		CASPA_HUMAN (4-206): 3.44e-48: 166: 19.12
+	Hs
		181627 DEDD2_HUMAN (12-309): 1.92e-129: 373: 43.93		CFLAR_HUMAN (6-193): 3.97e-39: 141: 16.67