Protein: HIP1
Huntingtin-interacting protein 1 (HIP-1) (Huntingtin-interacting protein I) (HIP-I)

Gene: HIP1
Organism: Homo sapiens
Interactions: 155
UniProt ID: O00291

Gene Ontology (top 5):
GO:0005154 - epidermal growth factor receptor binding
GO:0005200 - structural constituent of cytoskeleton
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005794 - Golgi apparatus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

130884

HIP1
Huntingtin-interacting protein 1

6

15

Small-scale

0.943

High

130900

HIP1R
Huntingtin-interacting protein 1-related protein

5

16

Small-scale

0.935

High

130911

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

8

Small-scale

0.793

High

130931

RD23B
UV excision repair protein RAD23 homolog B

2

6

High-throughput

0.783

High

130925

HD
Huntingtin

7

3

Small-scale

0.749

High

130942

CLH1
Clathrin heavy chain 1

7

4

Small-scale

0.744

High

130945

DEUP1
Deuterosome assembly protein 1

3

19

High-throughput

0.667

High

131031

GLSL
Glutaminase liver isoform, mitochondrial

3

5

High-throughput

0.665

High

130908

CLCB
Clathrin light chain B

3

6

Small-scale

0.664

High

130907

CLCA
Clathrin light chain A

3

6

High-throughput

0.662

High

131008

LITAF
Lipopolysaccharide-induced tumor necrosis factor-alpha factor

3

0

High-throughput

0.632

High

131004

CPNE2
Copine-2

2

2

High-throughput

0.628

High

130894

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.618

High

130960

TCEA2
Transcription elongation factor A protein 2

2

3

High-throughput

0.606

High

130989

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

2

3

High-throughput

0.606

High

130994

LNX1
E3 ubiquitin-protein ligase LNX

2

3

High-throughput

0.606

High

131011

SYT17
Synaptotagmin-17

2

2

High-throughput

0.606

High

130956

DAZP2
DAZ-associated protein 2

2

0

High-throughput

0.601

High

131024

IFT57
Intraflagellar transport protein 57 homolog

2

0

Small-scale

0.593

High

130903

EGFR
Epidermal growth factor receptor

2

10

Small-scale

0.584

High

130937

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.584

High

130955

CASP8
Caspase-8

2

3

Small-scale

0.584

High

131021

RPRM
Protein reprimo

2

0

High-throughput

0.580

High

131023

CYRIB
CYFIP-related Rac1 interactor B

2

0

High-throughput

0.580

High

130944

REL
Proto-oncogene c-Rel

1

2

High-throughput

0.573

High

130905

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

130929

CLH2
Clathrin heavy chain 2

1

4

Small-scale

0.568

High

130886

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

6

High-throughput

0.560

High

131006

CFA53
Cilia- and flagella-associated protein 53

2

13

High-throughput

0.553

High

130913

TAU
Microtubule-associated protein tau

2

9

High-throughput

0.552

High

131010

KXDL1
KxDL motif-containing protein 1

2

1

High-throughput

0.549

High

130902

AP2A1
AP-2 complex subunit alpha-1

1

5

Small-scale

0.541

High

130926

RS10
Small ribosomal subunit protein eS10

1

3

High-throughput

0.541

High

130888

GAK
Cyclin-G-associated kinase

1

15

High-throughput

0.536

High

130899

AUXI
Auxilin

1

7

High-throughput

0.536

High

130910

PARP1
Poly [ADP-ribose] polymerase 1

1

4

High-throughput

0.536

High

130917

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

5

High-throughput

0.536

High

130921

MYH9
Myosin-9

1

18

High-throughput

0.536

High

130927

CAPZB
F-actin-capping protein subunit beta

1

4

High-throughput

0.536

High

130952

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

17

High-throughput

0.536

High

130973

ZFP1
Zinc finger protein 1 homolog

1

1

High-throughput

0.536

High

131017

PAAT
ATPase PAAT

1

1

High-throughput

0.536

High

131026

GTSE1
G2 and S phase-expressed protein 1

1

3

High-throughput

0.536

High

131035

MB212
Protein mab-21-like 2

1

1

High-throughput

0.536

High

130898

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.518

High

130957

PLEC
Plectin

1

12

High-throughput

0.515

High

130891

TGM5
Protein-glutamine gamma-glutamyltransferase 5

1

2

High-throughput

0.515

High

130896

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

4

High-throughput

0.515

High

130904

CO2A1
Collagen alpha-1(II) chain

1

1

High-throughput

0.515

High

130916

SCP2
Sterol carrier protein 2

1

1

High-throughput

0.515

High

130919

CTNB1
Catenin beta-1

1

6

High-throughput

0.515

High

130922

TRI23
E3 ubiquitin-protein ligase TRIM23

1

2

High-throughput

0.515

High

130924

CDN2C
Cyclin-dependent kinase 4 inhibitor C

1

6

High-throughput

0.515

High

130930

TERF1
Telomeric repeat-binding factor 1

1

4

High-throughput

0.515

High

130946

GABP1
GA-binding protein subunit beta-1

1

4

High-throughput

0.515

High

130948

RBBP4
Histone-binding protein RBBP4

1

3

High-throughput

0.515

High

130951

SNW1
SNW domain-containing protein 1

1

4

High-throughput

0.515

High

130958

RHEB
GTP-binding protein Rheb

1

5

High-throughput

0.515

High

130982

SPART
Spartin

1

9

High-throughput

0.515

High

130987

RNF10
E3 ubiquitin-protein ligase RNF10

1

3

High-throughput

0.515

High

130988

KCD17
BTB/POZ domain-containing protein KCTD17

1

16

High-throughput

0.515

High

130997

RAB2B
Ras-related protein Rab-2B

1

2

High-throughput

0.515

High

131002

SPSB1
SPRY domain-containing SOCS box protein 1

1

15

High-throughput

0.515

High

131003

HBAP1
HSPB1-associated protein 1

1

1

High-throughput

0.515

High

131015

LHX5
LIM/homeobox protein Lhx5

1

1

High-throughput

0.515

High

131020

TIGAR
Fructose-2,6-bisphosphatase TIGAR

1

2

High-throughput

0.515

High

131022

BRWD1
Bromodomain and WD repeat-containing protein 1

1

8

High-throughput

0.515

High

131036

ACL7B
Actin-like protein 7B

1

15

High-throughput

0.515

High

130985

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

0

High-throughput

0.513

High

130964

MK06
Mitogen-activated protein kinase 6

1

11

High-throughput

0.508

High

130949

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

15

Small-scale

0.501

High

130995

FBX25
F-box only protein 25

1

8

Small-scale

0.501

High

131019

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

4

Small-scale

0.501

High

129611

CBX4
E3 SUMO-protein ligase CBX4

1

0

High-throughput

0.493

High

130889

TELT
Telethonin

1

0

High-throughput

0.493

High

130893

ZBT14
Zinc finger and BTB domain-containing protein 14

1

0

High-throughput

0.493

High

130918

MPI
Mannose-6-phosphate isomerase

1

0

High-throughput

0.493

High

130923

8ODP
Oxidized purine nucleoside triphosphate hydrolase

1

0

High-throughput

0.493

High

130947

ECHP
Peroxisomal bifunctional enzyme

1

0

High-throughput

0.493

High

130953

C1D
Nuclear nucleic acid-binding protein C1D

1

0

High-throughput

0.493

High

130954

BAAT
Bile acid-CoA:amino acid N-acyltransferase

1

0

High-throughput

0.493

High

130959

SF3B3
Splicing factor 3B subunit 3

1

0

High-throughput

0.493

High

130961

NAB2
NGFI-A-binding protein 2

1

0

High-throughput

0.493

High

130966

GLYR1
Cytokine-like nuclear factor N-PAC

1

0

High-throughput

0.493

High

130968

ZNG1C
Zinc-regulated GTPase metalloprotein activator 1C

1

0

High-throughput

0.493

High

130977

EST1A
Telomerase-binding protein EST1A

1

0

High-throughput

0.493

High

130979

ARCH
Protein archease

1

0

High-throughput

0.493

High

130993

PEPL1
Probable aminopeptidase NPEPL1

1

0

High-throughput

0.493

High

131001

TET5B
Terminal nucleotidyltransferase 5B

1

0

High-throughput

0.493

High

131007

KAD8
Adenylate kinase 8

1

0

High-throughput

0.493

High

131009

DPYL5
Dihydropyrimidinase-related protein 5

1

0

High-throughput

0.493

High

131012

SHP1L
Testicular spindle-associated protein SHCBP1L

1

0

High-throughput

0.493

High

131014

ATG10
Ubiquitin-like-conjugating enzyme ATG10

1

0

High-throughput

0.493

High

131028

VPS54
Vacuolar protein sorting-associated protein 54

1

0

High-throughput

0.493

High

131029

SPMA2
Sperm microtubule associated protein 2

1

0

High-throughput

0.493

High

131032

JUPI1
Jupiter microtubule associated homolog 1

1

0

High-throughput

0.493

High

131033

OCTC
Peroxisomal carnitine O-octanoyltransferase

1

0

High-throughput

0.493

High

131034

NAGA
N-acetylglucosamine-6-phosphate deacetylase

1

0

High-throughput

0.493

High

130962

ITSN1
Intersectin-1

1

5

High-throughput

0.481

High

131025

TBA8
Tubulin alpha-8 chain

1

1

High-throughput

0.481

High

130885

CTRO
Citron Rho-interacting kinase

1

19

High-throughput

0.479

High

130887

APAF
Apoptotic protease-activating factor 1

1

8

Small-scale

0.479

High

130892

STX6
Syntaxin-6

1

1

High-throughput

0.479

High

130895

NUPR1
Nuclear protein 1

1

2

High-throughput

0.479

High

130906

NTRK1
High affinity nerve growth factor receptor

1

13

High-throughput

0.479

High

130909

PGFRB
Platelet-derived growth factor receptor beta

1

3

Small-scale

0.479

High

130914

CFTR
Cystic fibrosis transmembrane conductance regulator

1

14

High-throughput

0.479

High

130932

CASP9
Caspase-9

1

3

Small-scale

0.479

High

130934

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

14

High-throughput

0.479

High

130935

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

1

6

Small-scale

0.479

High

130936

H2B1D
Histone H2B type 1-D

1

18

High-throughput

0.479

High

130939

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

130940

AP2B1
AP-2 complex subunit beta

1

6

High-throughput

0.479

High

130941

RHG04
Rho GTPase-activating protein 4

1

3

High-throughput

0.479

High

130943

TOP2B
DNA topoisomerase 2-beta

1

4

High-throughput

0.479

High

130970

A16L1
Autophagy-related protein 16-1

1

8

High-throughput

0.479

High

130974

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.479

High

130975

ATG9A
Autophagy-related protein 9A

1

3

High-throughput

0.479

High

130976

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

130984

RHG18
Rho GTPase-activating protein 18

1

3

High-throughput

0.479

High

130991

SERB1
SERPINE1 mRNA-binding protein 1

1

4

High-throughput

0.479

High

131000

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

131016

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

131018

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

131027

BFAR
Bifunctional apoptosis regulator

1

10

Small-scale

0.479

High

131030

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

1

High-throughput

0.479

High

130928

RGR
RPE-retinal G protein-coupled receptor

1

4

High-throughput

0.470

High

130980

LRC56
Leucine-rich repeat-containing protein 56

1

9

High-throughput

0.470

High

130986

KLH36
Kelch-like protein 36

1

3

High-throughput

0.470

High

130990

WDR31
WD repeat-containing protein 31

1

7

High-throughput

0.470

High

130998

BSND
Barttin

1

1

High-throughput

0.470

High

131005

F167A
Protein FAM167A

1

2

High-throughput

0.470

High

130933

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.460

High

130996

SMAP2
Stromal membrane-associated protein 2

1

0

High-throughput

0.458

High

130897

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

4

High-throughput

0.445

High

130912

CALM3
Calmodulin-3

1

3

High-throughput

0.445

High

130915

VCAM1
Vascular cell adhesion protein 1

1

6

High-throughput

0.445

High

130920

BMI1
Polycomb complex protein BMI-1

1

6

High-throughput

0.445

High

130938

H2B1C
Histone H2B type 1-C/E/F/G/I

1

18

High-throughput

0.445

High

130971

PKHA7
Pleckstrin homology domain-containing family A member 7

1

19

High-throughput

0.445

High

131013

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

130950

CENPR
Centromere protein R

1

0

High-throughput

0.438

High

130890

STX7
Syntaxin-7

1

4

High-throughput

0.437

High

130901

DIRA3
GTP-binding protein Di-Ras3

1

5

High-throughput

0.437

High

130983

CXD3
Gap junction delta-3 protein

1

7

High-throughput

0.437

High

130999

F168A
Protein FAM168A

2

0

High-throughput

0.316

High

130963

LPAL2
Putative apolipoprotein(a)-like protein 2

1

0

High-throughput

0.268

Low

130965

CC036
Uncharacterized protein C3orf36

1

0

High-throughput

0.268

Low

130967

ZC21C
Zinc finger C2HC domain-containing protein 1C

1

0

High-throughput

0.268

Low

130969

SPRY7
SPRY domain-containing protein 7

1

0

High-throughput

0.268

Low

130972

OGFD2
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2

1

0

High-throughput

0.268

Low

130981

FAM9A
Protein FAM9A

1

0

High-throughput

0.268

Low

130992

PRCA1
Protein PROCA1

1

0

High-throughput

0.268

Low

130978

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025