HitPredict

Interactor 1: PRDM1 (O75626)
PR domain zinc finger protein 1 (EC 2.1.1.-) (BLIMP-1) (Beta-interferon gene positive regulatory domain I-binding factor) (PR domain-containing protein 1) (Positive regulatory domain I-binding factor 1) (PRDI-BF1) (PRDI-binding factor 1)
Gene: PRDM1

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.713

Property	Details
Experiments	12626569, 19124609, 10713181, 22555612, 22733990
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:1990841 - promoter-specific chromatin binding
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 825 Hs			1 488
+	Mm
		936395 PRDM1_MOUSE (12-825): 0: 620: 88.47		HDAC2_MOUSE (1-488): 0: 704: 99.39
+	Hs
		1251257 ZN461_HUMAN (576-714): 4e-16: 84.3: 35.25		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Mm
		93753 ZN431_MOUSE (559-629): 6.19e-10: 64.7: 39.44		HDAC2_MOUSE (1-488): 0: 704: 99.39
+	Hs
		271762 PRDM1_HUMAN (344-488): 1.11e-27: 122: 4.76		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Mm
		93752 ZN431_MOUSE (559-629): 6.19e-10: 64.7: 39.44		HDAC1_MOUSE (1-443): 0: 645: 90.29