HitPredict

Interactor 1: RFIP3 (O75154)
Rab11 family-interacting protein 3 (FIP3) (FIP3-Rab11) (Rab11-FIP3) (Arfophilin-1) (EF hands-containing Rab-interacting protein) (Eferin) (MU-MB-17.148)
Gene: RAB11FIP3

Interactor 2: RB11B (Q15907)
Ras-related protein Rab-11B (EC 3.6.5.2) (GTP-binding protein YPT3)
Gene: RAB11B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.744

Property	Details
Experiments	11495908, unassigned3799
Identification Methods	two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	RBD-FIP~Ras
Common GO terms	GO:0005829 - cytosol GO:0032456 - endocytic recycling GO:0055037 - recycling endosome GO:0055038 - recycling endosome membrane GO:2001135 - regulation of endocytic recycling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 756 Hs			1 218
+	Hs
		273131 RFIP3_HUMAN (1-756): 4.47e-163: 491: 100.00		RB11A_HUMAN (1-218): 3.63e-90: 265: 90.37
+	Hs
		273129 RFIP3_HUMAN (1-756): 4.47e-163: 491: 100.00		RAB25_HUMAN (2-218): 1.31e-83: 249: 60.63
+	Dm
		197342 Q8SYQ0_DROME (420-756): 3.62e-52: 191: 28.77		O18335_DROME (1-216): 1.86e-85: 253: 83.80
+	Dm
		197322 Q6NN29_DROME (460-756): 7.29e-50: 185: 29.90		O18335_DROME (1-216): 1.86e-85: 253: 83.80
+	Hs
		1155362 RFIP4_HUMAN (188-756): 1.14e-32: 136: 33.33		RB11B_HUMAN (1-218): 6.92e-94: 275: 100.00
+	Hs
		976390 RFIP4_HUMAN (188-756): 1.14e-32: 136: 33.33		RB11A_HUMAN (1-218): 3.63e-90: 265: 90.37
+	Hs
		976228 GOGA2_HUMAN (162-756): 4.67e-27: 120: 11.93		RB11A_HUMAN (1-218): 3.63e-90: 265: 90.37
+	Hs
		981262 GOGA2_HUMAN (162-756): 4.67e-27: 120: 11.93		RAB1A_HUMAN (1-215): 5.62e-90: 264: 43.26
+	Hs
		976324 MRCKA_HUMAN (255-752): 2.85e-25: 114: 10.00		RB11A_HUMAN (1-218): 3.63e-90: 265: 90.37
+	Hs
		976588 MYO5C_HUMAN (415-756): 1e-24: 112: 12.47		RB11A_HUMAN (1-218): 3.63e-90: 265: 90.37
+	Hs
		1063607 GOGA2_HUMAN (162-756): 4.67e-27: 120: 11.93		RAB1B_HUMAN (4-215): 1.04e-86: 256: 44.81
+	Hs
		1063475 GOGA2_HUMAN (162-756): 4.67e-27: 120: 11.93		RAB2B_HUMAN (7-215): 1.34e-83: 249: 46.98
+	Hs
		976290 ITSN1_HUMAN (367-749): 1.27e-20: 99.8: 10.59		RB11A_HUMAN (1-218): 3.63e-90: 265: 90.37
+	Hs
		157196 CTRO_HUMAN (191-750): 2.22e-20: 99: 10.61		RAB1A_HUMAN (1-215): 5.62e-90: 264: 43.26
+	Hs
		157837 CTRO_HUMAN (191-750): 2.22e-20: 99: 10.61		RAB1B_HUMAN (4-215): 1.04e-86: 256: 44.81
+	Hs
		944975 TMF1_HUMAN (316-748): 1.6e-13: 76.7: 20.36		RAB25_HUMAN (2-218): 1.31e-83: 249: 60.63
+	Hs
		956269 GOGA2_HUMAN (162-756): 4.67e-27: 120: 11.93		RAB2A_HUMAN (8-178): 5.92e-61: 191: 55.56
+	Hs
		956337 MRCKA_HUMAN (255-752): 2.85e-25: 114: 10.00		RAB2A_HUMAN (8-178): 5.92e-61: 191: 55.56
+	Hs
		956430 MY18A_HUMAN (384-755): 2.93e-23: 108: 12.80		RAB2A_HUMAN (8-178): 5.92e-61: 191: 55.56
+	Hs
		956291 DCTN1_HUMAN (553-756): 1.17e-13: 77: 16.36		RAB2A_HUMAN (8-178): 5.92e-61: 191: 55.56