HitPredict - High confidence protein-protein interactions

Interactor 1: RENR (O75787)
Renin receptor (ATPase H(+)-transporting lysosomal accessory protein 2) (ATPase H(+)-transporting lysosomal-interacting protein 2) (ER-localized type I transmembrane adapter) (Embryonic liver differentiation factor 10) (N14F) (Renin/prorenin receptor) (Vacuolar ATP synthase membrane sector-associated protein M8-9) (ATP6M8-9) (V-ATPase M8.9 subunit) [Cleaved into: Renin receptor N-terminal fragment; Renin receptor C-terminal fragment]
Gene: ATP6AP2

Interactor 2: RENR (O75787)
Renin receptor (ATPase H(+)-transporting lysosomal accessory protein 2) (ATPase H(+)-transporting lysosomal-interacting protein 2) (ER-localized type I transmembrane adapter) (Embryonic liver differentiation factor 10) (N14F) (Renin/prorenin receptor) (Vacuolar ATP synthase membrane sector-associated protein M8-9) (ATP6M8-9) (V-ATPase M8.9 subunit) [Cleaved into: Renin receptor N-terminal fragment; Renin receptor C-terminal fragment]
Gene: ATP6AP2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.55	0.613

Property	Details
Experiments	29127204, 24472541, 21420935
Identification Methods	affinity chromatography technology, pull down, x-ray crystallography
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000139 - Golgi membrane GO:0000220 - vacuolar proton-transporting V-type ATPase, V0 domain GO:0000421 - autophagosome membrane GO:0002003 - angiotensin maturation GO:0005764 - lysosome and 32 others more... GO:0005765 - lysosomal membrane GO:0005789 - endoplasmic reticulum membrane GO:0005886 - plasma membrane GO:0007035 - vacuolar acidification GO:0007042 - lysosomal lumen acidification GO:0009897 - external side of plasma membrane GO:0010008 - endosome membrane GO:0016020 - membrane GO:0016471 - vacuolar proton-transporting V-type ATPase complex GO:0021626 - central nervous system maturation GO:0021903 - rostrocaudal neural tube patterning GO:0030177 - positive regulation of Wnt signaling pathway GO:0030424 - axon GO:0030665 - clathrin-coated vesicle membrane GO:0030672 - synaptic vesicle membrane GO:0032591 - dendritic spine membrane GO:0032914 - positive regulation of transforming growth factor beta1 production GO:0033176 - proton-transporting V-type ATPase complex GO:0038023 - signaling receptor activity GO:0043408 - regulation of MAPK cascade GO:0045211 - postsynaptic membrane GO:0048069 - eye pigmentation GO:0048388 - endosomal lumen acidification GO:0051452 - intracellular pH reduction GO:0060323 - head morphogenesis GO:0061795 - Golgi lumen acidification GO:0070062 - extracellular exosome GO:0070821 - tertiary granule membrane GO:0090263 - positive regulation of canonical Wnt signaling pathway GO:0097401 - synaptic vesicle lumen acidification GO:0101003 - ficolin-1-rich granule membrane GO:1902600 - proton transmembrane transport
Homologous interactions	0

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Last updated: 15 Jul 2024