HitPredict

Interactor 1: BCAR3 (O75815)
Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B)
Gene: BCAR3

Interactor 2: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	16273093
Identification Methods	unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0007165 - signal transduction GO:0008284 - positive regulation of cell population proliferation GO:0016020 - membrane GO:0043410 - positive regulation of MAPK cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 825 Hs			1 1255
+	Hs
		383882 SH2D3_HUMAN (8-825): 0: 686: 39.39		ERBB2_HUMAN (1-1255): 0: 1282: 100.00
+	Hs
		275573 BCAR3_HUMAN (1-825): 0: 867: 100.00		ERBB4_HUMAN (6-1237): 0: 1098: 45.45
+	Hs
		275521 BCAR3_HUMAN (1-825): 0: 867: 100.00		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		275537 BCAR3_HUMAN (1-825): 0: 867: 100.00		ERBB3_HUMAN (5-1254): 0: 1041: 38.55
+	Hs
		383953 SH23A_HUMAN (141-817): 1.02e-175: 520: 34.71		ERBB2_HUMAN (1-1255): 0: 1282: 100.00
+	Hs
		1070984 SH2D3_HUMAN (8-825): 0: 686: 39.39		ERBB4_HUMAN (6-1237): 0: 1098: 45.45
+	Hs
		338698 SH2D3_HUMAN (8-825): 0: 686: 39.39		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		601949 SH2D3_HUMAN (8-825): 0: 686: 39.39		ERBB3_HUMAN (5-1254): 0: 1041: 38.55
+	Hs
		338911 SH23A_HUMAN (141-817): 1.02e-175: 520: 34.71		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		601989 SH23A_HUMAN (141-817): 1.02e-175: 520: 34.71		ERBB3_HUMAN (5-1254): 0: 1041: 38.55
+	Hs
		383538 YES_HUMAN (2-333): 6.77e-61: 217: 13.14		ERBB2_HUMAN (1-1255): 0: 1282: 100.00
+	Rn
		1225226 SRC_RAT (22-349): 4.06e-61: 217: 14.37		Q8K3F9_RAT (1-1255): 0: 1275: 87.98
+	Rn
		1351588 SRC_RAT (22-349): 4.06e-61: 217: 14.37		Q9QX70_RAT (21-1254): 0: 1116: 48.96
+	Hs
		433359 YES_HUMAN (2-333): 6.77e-61: 217: 13.14		ERBB4_HUMAN (6-1237): 0: 1098: 45.45
+	Hs
		337789 YES_HUMAN (2-333): 6.77e-61: 217: 13.14		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		433253 YES_HUMAN (2-333): 6.77e-61: 217: 13.14		ERBB3_HUMAN (5-1254): 0: 1041: 38.55
+	Hs
		433265 YES_HUMAN (2-333): 6.77e-61: 217: 13.14		EPHB2_HUMAN (650-1103): 2.29e-122: 406: 29.47
+	Rn
		936859 SRC_RAT (22-349): 4.06e-61: 217: 14.37		FAK2_RAT (724-982): 4.66e-54: 207: 40.08
+	Hs
		433329 YES_HUMAN (2-333): 6.77e-61: 217: 13.14		FAK1_HUMAN (706-984): 1.9e-53: 206: 39.07
+	Hs
		111147 YES_HUMAN (2-333): 6.77e-61: 217: 13.14		I6L996_HUMAN (706-984): 3.35e-54: 204: 39.07