HitPredict

Interactor 1: BCAR3 (O75815)
Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B)
Gene: BCAR3

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~SH3_1, SH2~SH3_2
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005737 - cytoplasm GO:0007165 - signal transduction GO:0016020 - membrane GO:0019900 - kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 825 Hs			1 304
+	Dm
		1370843 Q9VMJ4_DROME (46-815): 0: 637: 26.35		CRK_DROME (5-302): 8.8e-52: 173: 43.14
+	Dm
		1250598 Q8T9B3_DROME (46-815): 0: 637: 26.47		Q95RW2_DROME (5-302): 3.29e-46: 158: 40.47
+	Hs
		548657 VAV_HUMAN (10-316): 3.02e-58: 215: 16.33		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		522848 SRC_HUMAN (33-349): 1.87e-59: 213: 13.95		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		433280 YES_HUMAN (2-333): 6.77e-61: 217: 13.14		CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07
+	Hs
		548628 VAV_HUMAN (10-316): 3.02e-58: 215: 16.33		VAV_HUMAN (11-189): 6.6e-47: 170: 28.21
+	Hs
		411981 FYN_HUMAN (12-349): 2.18e-58: 210: 11.85		VAV_HUMAN (11-189): 6.6e-47: 170: 28.21
+	Hs
		548634 VAV_HUMAN (10-316): 3.02e-58: 215: 16.33		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		522758 SRC_HUMAN (33-349): 1.87e-59: 213: 13.95		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		548630 VAV_HUMAN (10-316): 3.02e-58: 215: 16.33		PLCG2_HUMAN (1-301): 1.03e-25: 109: 15.89
+	Hs
		412000 FYN_HUMAN (12-349): 2.18e-58: 210: 11.85		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		411992 FYN_HUMAN (12-349): 2.18e-58: 210: 11.85		PLCG2_HUMAN (1-301): 1.03e-25: 109: 15.89
+	Mm
		763400 FYN_MOUSE (12-349): 2.32e-58: 210: 11.85		PLCG2_MOUSE (11-301): 1.34e-25: 108: 16.40
+	Hs
		548677 VAV_HUMAN (10-316): 3.02e-58: 215: 16.33		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		924777 Q96D37_HUMAN (10-316): 1.64e-58: 215: 16.33		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		522887 SRC_HUMAN (33-349): 1.87e-59: 213: 13.95		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Mm
		763393 FYN_MOUSE (12-349): 2.32e-58: 210: 11.85		GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67
+	Hs
		523104 SRC_HUMAN (33-349): 1.87e-59: 213: 13.95		SH3K1_HUMAN (114-192): 4.08e-10: 62.5: 22.22
+	Hs
		411986 FYN_HUMAN (12-349): 2.18e-58: 210: 11.85		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Mm
		763403 FYN_MOUSE (12-349): 2.32e-58: 210: 11.85		NCK1_MOUSE (2-100): 1.35e-10: 63.3: 18.00