Protein: SCYL1
N-terminal kinase-like protein (Coated vesicle-associated kinase of 90 kDa) (SCY1-like protein 1) (Telomerase regulation-associated protein) (Telomerase transcriptional element-interacting factor) (Teratoma-associated tyrosine kinase)

Gene: SCYL1
Organism: Homo sapiens
Interactions: 208
UniProt ID: Q96KG9

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0004672 - protein kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

170288

AURKA
Aurora kinase A

4

17

High-throughput

0.895

High

1396027

SCYL1
N-terminal kinase-like protein

2

17

Small-scale

0.757

High

242607

PRKN
E3 ubiquitin-protein ligase parkin

2

11

High-throughput

0.754

High

831257

CCNF
Cyclin-F

1

2

Small-scale

0.740

High

323902

SC31A
Protein transport protein Sec31A

5

2

High-throughput

0.722

High

1396045

PKHF2
Pleckstrin homology domain-containing family F member 2

2

2

High-throughput

0.700

High

181157

AXIN1
Axin-1

1

2

High-throughput

0.698

High

719170

MPIP1
M-phase inducer phosphatase 1

1

1

High-throughput

0.698

High

920493

DAPK1
Death-associated protein kinase 1

1

13

High-throughput

0.692

High

955479

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.691

High

1061099

SRSF1
Serine/arginine-rich splicing factor 1

1

5

High-throughput

0.691

High

1160250

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

5

High-throughput

0.691

High

1160825

MAPK3
MAP kinase-activated protein kinase 3

1

5

High-throughput

0.691

High

1351860

NEK7
Serine/threonine-protein kinase Nek7

1

17

High-throughput

0.691

High

1396046

CLXN
Calaxin

1

20

High-throughput

0.691

High

1396067

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

13

High-throughput

0.691

High

277467

AVIL
Advillin

2

1

High-throughput

0.628

High

1396053

PLCC
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

2

2

High-throughput

0.628

High

158289

COPE
Coatomer subunit epsilon

2

1

Small-scale

0.619

High

873289

COPD
Coatomer subunit delta

2

2

Small-scale

0.619

High

921749

COPB
Coatomer subunit beta

2

5

Small-scale

0.619

High

921991

COPA
Coatomer subunit alpha

2

4

Small-scale

0.619

High

1396074

COPG1
Coatomer subunit gamma-1

2

6

Small-scale

0.619

High

1359386

DNJB3
DnaJ homolog subfamily B member 3

1

3

High-throughput

0.618

High

363721

EGFR
Epidermal growth factor receptor

1

8

High-throughput

0.618

High

412448

NTRK1
High affinity nerve growth factor receptor

1

16

High-throughput

0.618

High

910167

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

1095293

REST
RE1-silencing transcription factor

1

1

Small-scale

0.618

High

1255101

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.618

High

1360800

ASB11
Ankyrin repeat and SOCS box protein 11

1

5

High-throughput

0.618

High

1396044

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.618

High

1396066

ALK
ALK tyrosine kinase receptor

1

15

High-throughput

0.618

High

329093

KLHL2
Kelch-like protein 2

2

4

High-throughput

0.611

High

1214418

GORAB
RAB6-interacting golgin

2

1

Small-scale

0.609

High

684354

DDX6
Probable ATP-dependent RNA helicase DDX6

2

2

High-throughput

0.606

High

1109356

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

2

1

High-throughput

0.606

High

1150158

TCEA2
Transcription elongation factor A protein 2

2

1

High-throughput

0.606

High

1396029

SORT
Sortilin

2

0

High-throughput

0.602

High

3355

A0A0S2Z4M1
Axin-1

1

2

High-throughput

0.590

High

1396047

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

0

Small-scale

0.589

High

791636

SYUA
Alpha-synuclein

2

1

High-throughput

0.586

High

462570

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

7

High-throughput

0.575

High

876969

KC1A
Casein kinase I isoform alpha

1

12

High-throughput

0.575

High

987164

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

4

High-throughput

0.575

High

1009870

NUCB2
Nucleobindin-2

1

1

High-throughput

0.575

High

1316278

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

18

High-throughput

0.575

High

1337635

PDZD8
PDZ domain-containing protein 8

1

1

High-throughput

0.575

High

1340951

MCFD2
Multiple coagulation factor deficiency protein 2

1

1

High-throughput

0.575

High

1396041

RGAP1
Rac GTPase-activating protein 1

1

1

High-throughput

0.575

High

1015091

ARF5
ADP-ribosylation factor 5

2

5

High-throughput

0.571

High

163464

MEIS2
Homeobox protein Meis2

1

2

High-throughput

0.536

High

321630

PRP6
Pre-mRNA-processing factor 6

1

5

High-throughput

0.536

High

352222

MBD3
Methyl-CpG-binding domain protein 3

1

1

High-throughput

0.536

High

391069

TRFL
Lactotransferrin

1

1

High-throughput

0.536

High

773601

COPB2
Coatomer subunit beta'

1

5

High-throughput

0.536

High

862939

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

5

High-throughput

0.536

High

867346

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.536

High

888961

TMEDA
Transmembrane emp24 domain-containing protein 10

1

5

High-throughput

0.536

High

925740

SC24C
Protein transport protein Sec24C

1

1

High-throughput

0.536

High

938268

SEC13
Protein SEC13 homolog

1

2

High-throughput

0.536

High

964051

COPZ1
Coatomer subunit zeta-1

1

2

High-throughput

0.536

High

1066165

NSUN2
RNA cytosine C(5)-methyltransferase NSUN2

1

1

High-throughput

0.536

High

1090001

LMAN2
Vesicular integral-membrane protein VIP36

1

1

High-throughput

0.536

High

1102629

MTA1
Metastasis-associated protein MTA1

1

2

High-throughput

0.536

High

1136997

SEPT2
Septin-2

1

3

High-throughput

0.536

High

1199022

KLH12
Kelch-like protein 12

1

4

High-throughput

0.536

High

1251412

GGYF2
GRB10-interacting GYF protein 2

1

13

High-throughput

0.536

High

1259137

LARP4
La-related protein 4

1

1

High-throughput

0.536

High

1270396

SND1
Staphylococcal nuclease domain-containing protein 1

1

1

High-throughput

0.536

High

1271662

EIF3M
Eukaryotic translation initiation factor 3 subunit M

1

1

High-throughput

0.536

High

1293398

CARM1
Histone-arginine methyltransferase CARM1

1

1

High-throughput

0.536

High

1336274

LS14A
Protein LSM14 homolog A

1

6

High-throughput

0.536

High

1363301

DDX1
ATP-dependent RNA helicase DDX1

1

3

High-throughput

0.536

High

1365729

GCN1
Stalled ribosome sensor GCN1

1

11

High-throughput

0.536

High

1396030

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.536

High

1396035

DDX23
Probable ATP-dependent RNA helicase DDX23

1

2

High-throughput

0.536

High

1396036

DUS23
Dual specificity protein phosphatase 23

1

9

High-throughput

0.536

High

1396037

BTBD2
BTB/POZ domain-containing protein 2

1

5

High-throughput

0.536

High

1396068

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

1

High-throughput

0.536

High

1396069

TR150
Thyroid hormone receptor-associated protein 3

1

5

High-throughput

0.536

High

1145655

RCN1
Reticulocalbin-1

1

3

High-throughput

0.514

High

64093

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

High-throughput

0.513

High

187776

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

0

High-throughput

0.513

High

335494

SLU7
Pre-mRNA-splicing factor SLU7

1

0

High-throughput

0.513

High

423825

APOD
Apolipoprotein D

1

0

High-throughput

0.513

High

784802

VATE1
V-type proton ATPase subunit E 1

1

0

High-throughput

0.513

High

834355

GARS
Glycine--tRNA ligase

1

0

High-throughput

0.513

High

949423

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

0

High-throughput

0.513

High

1032772

SATB1
DNA-binding protein SATB1

1

0

High-throughput

0.513

High

1258672

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

1

0

High-throughput

0.513

High

1396062

NXF1
Nuclear RNA export factor 1

1

0

High-throughput

0.513

High

422894

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

958809

ARF3
ADP-ribosylation factor 3

1

5

Small-scale

0.501

High

1014942

ARF1
ADP-ribosylation factor 1

1

5

Small-scale

0.501

High

1396048

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

5

Small-scale

0.501

High

1254273

UBR3
E3 ubiquitin-protein ligase UBR3

1

0

High-throughput

0.493

High

261251

NSMA
Sphingomyelin phosphodiesterase 2

1

1

High-throughput

0.489

High

1053379

CTSL2
CTD small phosphatase-like protein 2

1

3

High-throughput

0.489

High

1179018

S35G1
Solute carrier family 35 member G1

1

1

High-throughput

0.489

High

800052

COIL
Coilin

1

0

High-throughput

0.486

High

1396050

C1QR1
Complement component C1q receptor

1

3

Small-scale

0.481

High

1292504

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

1

1

High-throughput

0.481

High

129336

MEN1
Menin

1

1

High-throughput

0.479

High

173238

XPO1
Exportin-1

1

11

High-throughput

0.479

High

191381

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

2

High-throughput

0.479

High

291492

NU155
Nuclear pore complex protein Nup155

1

2

High-throughput

0.479

High

327412

ZFPL1
Zinc finger protein-like 1

1

3

High-throughput

0.479

High

556286

CADH1
Cadherin-1

1

6

High-throughput

0.479

High

604156

CXA1
Gap junction alpha-1 protein

1

7

High-throughput

0.479

High

696234

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

894977

EMD
Emerin

1

1

High-throughput

0.479

High

1058595

CKAP4
Cytoskeleton-associated protein 4

1

5

High-throughput

0.479

High

1067607

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.479

High

1155666

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

1276648

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

1367034

ESR2
Estrogen receptor beta

1

8

High-throughput

0.479

High

1396040

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

5

High-throughput

0.479

High

1396052

SAR1A
Small COPII coat GTPase SAR1A

1

12

High-throughput

0.479

High

1396055

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.479

High

1396063

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1396064

TES
Testin

1

2

High-throughput

0.479

High

1396065

AGO2
Protein argonaute-2

1

4

Small-scale

0.479

High

1396075

NFS1
Cysteine desulfurase

1

1

High-throughput

0.479

High

1396076

SAR1B
Small COPII coat GTPase SAR1B

1

10

High-throughput

0.479

High

809786

RS19
Small ribosomal subunit protein eS19

1

0

High-throughput

0.458

High

1026511

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

48741

ESYT2
Extended synaptotagmin-2

1

4

High-throughput

0.445

High

50665

HACL2
2-hydroxyacyl-CoA lyase 2

1

1

High-throughput

0.445

High

60396

NBAS
NBAS subunit of NRZ tethering complex

1

1

High-throughput

0.445

High

104360

F5H6I7
Atlastin GTPase 3

1

5

High-throughput

0.445

High

211838

ZW10
Centromere/kinetochore protein zw10 homolog

1

1

High-throughput

0.445

High

213640

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

2

High-throughput

0.445

High

215629

EMC8
ER membrane protein complex subunit 8

1

1

High-throughput

0.445

High

296552

STAM2
Signal transducing adapter molecule 2

1

7

High-throughput

0.445

High

319014

MICA2
[F-actin]-monooxygenase MICAL2

1

6

High-throughput

0.445

High

328978

RTN3
Reticulon-3

1

5

High-throughput

0.445

High

333143

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

5

High-throughput

0.445

High

360079

NB5R3
NADH-cytochrome b5 reductase 3

1

1

High-throughput

0.445

High

535417

BIP
Endoplasmic reticulum chaperone BiP

1

6

High-throughput

0.445

High

567055

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

2

High-throughput

0.445

High

697993

CALR
Calreticulin

1

4

High-throughput

0.445

High

699017

CALX
Calnexin

1

4

High-throughput

0.445

High

883131

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

1

1

High-throughput

0.445

High

904073

BAP31
B-cell receptor-associated protein 31

1

1

High-throughput

0.445

High

1097028

PRDX4
Peroxiredoxin-4

1

2

High-throughput

0.445

High

1131353

GANAB
Neutral alpha-glucosidase AB

1

1

High-throughput

0.445

High

1136319

EMC2
ER membrane protein complex subunit 2

1

3

High-throughput

0.445

High

1139246

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

1

High-throughput

0.445

High

1139366

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

1

High-throughput

0.445

High

1146607

TMED2
Transmembrane emp24 domain-containing protein 2

1

5

High-throughput

0.445

High

1147822

DHC24
Delta(24)-sterol reductase

1

2

High-throughput

0.445

High

1248646

LCLT1
Lysocardiolipin acyltransferase 1

1

2

High-throughput

0.445

High

1258797

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

3

High-throughput

0.445

High

1327934

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

1

High-throughput

0.445

High

1330357

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.445

High

1333955

DHB11
Estradiol 17-beta-dehydrogenase 11

1

5

High-throughput

0.445

High

1338208

VP37A
Vacuolar protein sorting-associated protein 37A

1

1

High-throughput

0.445

High

1340088

ATLA2
Atlastin-2

1

5

High-throughput

0.445

High

1340189

ARK74
Aflatoxin B1 aldehyde reductase member 4

1

2

High-throughput

0.445

High

1358339

SCFD1
Sec1 family domain-containing protein 1

1

4

High-throughput

0.445

High

1360557

ATLA1
Atlastin-1

1

5

High-throughput

0.445

High

1381489

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

1

High-throughput

0.445

High

1386176

ASTRA
Protein Aster-A

1

1

High-throughput

0.445

High

1396028

NUDC1
NudC domain-containing protein 1

1

1

High-throughput

0.445

High

1396031

PXL2A
Peroxiredoxin-like 2A

1

1

High-throughput

0.445

High

1396032

ERP44
Endoplasmic reticulum resident protein 44

1

1

High-throughput

0.445

High

1396033

ESYT1
Extended synaptotagmin-1

1

6

High-throughput

0.445

High

1396034

NDC1
Nucleoporin NDC1

1

1

High-throughput

0.445

High

1396038

WDR11
WD repeat-containing protein 11

1

1

High-throughput

0.445

High

1396039

LNP
Endoplasmic reticulum junction formation protein lunapark

1

1

High-throughput

0.445

High

1396042

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

1

High-throughput

0.445

High

1396049

APMAP
Adipocyte plasma membrane-associated protein

1

1

High-throughput

0.445

High

1396051

RTN4
Reticulon-4

1

5

High-throughput

0.445

High

1396054

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

2

High-throughput

0.445

High

1396056

TM38B
Trimeric intracellular cation channel type B

1

1

High-throughput

0.445

High

1396057

GPTC2
G patch domain-containing protein 2

1

1

High-throughput

0.445

High

1396059

TECR
Very-long-chain enoyl-CoA reductase

1

1

High-throughput

0.445

High

1396060

VAPA
Vesicle-associated membrane protein-associated protein A

1

5

High-throughput

0.445

High

1396061

COPG2
Coatomer subunit gamma-2

1

6

High-throughput

0.445

High

1396071

DHRS7
Dehydrogenase/reductase SDR family member 7

1

3

High-throughput

0.445

High

1396072

TMED5
Transmembrane emp24 domain-containing protein 5

1

5

High-throughput

0.445

High

1396073

SERC
Phosphoserine aminotransferase

1

1

High-throughput

0.445

High

106473

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

139963

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

4

High-throughput

0.437

High

768914

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

1293113

TMM17
Transmembrane protein 17

1

4

High-throughput

0.437

High

1322951

CXD3
Gap junction delta-3 protein

1

7

High-throughput

0.437

High

1388482

ZMY19
Zinc finger MYND domain-containing protein 19

1

0

High-throughput

0.426

High

94323

D6R9G5
Kelch like family member 2

1

7

High-throughput

0.407

High

275551

RTN2
Reticulon-2

1

5

High-throughput

0.407

High

283336

ERLN1
Erlin-1

1

1

High-throughput

0.407

High

903767

SSRD
Translocon-associated protein subunit delta

1

1

High-throughput

0.407

High

1027140

REEP5
Receptor expression-enhancing protein 5

1

1

High-throughput

0.407

High

1045038

PRB3
Basic salivary proline-rich protein 3

1

3

High-throughput

0.407

High

1152839

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

2

High-throughput

0.407

High

1199238

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

6

High-throughput

0.407

High

1396043

TMX1
Thioredoxin-related transmembrane protein 1

1

3

High-throughput

0.407

High

1396058

PSD3
PH and SEC7 domain-containing protein 3

1

5

High-throughput

0.407

High

1385248

LENG1
Leukocyte receptor cluster member 1

2

0

High-throughput

0.316

High

143972

EST2
Cocaine esterase

1

0

High-throughput

0.279

Low

1200585

CTSRT
Cation channel sperm-associated targeting subunit tau

1

0

High-throughput

0.279

Low

1396070

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

High-throughput

0.279

Low

377690

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

657656

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.249

Low

1249125

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1382910

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.249

Low

71605

RUXGL
Putative small nuclear ribonucleoprotein G-like protein 15

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025