HitPredict

Interactor 1: PIAS1 (O75925)
E3 SUMO-protein ligase PIAS1 (EC 2.3.2.-) (DEAD/H box-binding protein 1) (E3 SUMO-protein transferase PIAS1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein)
Gene: PIAS1

Interactor 2: SUMO1 (P63165)
Small ubiquitin-related modifier 1 (SUMO-1) (GAP-modifying protein 1) (GMP1) (SMT3 homolog 3) (Sentrin) (Ubiquitin-homology domain protein PIC1) (Ubiquitin-like protein SMT3C) (Smt3C) (Ubiquitin-like protein UBL1)
Gene: SUMO1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.974

The method score is based on:

Property Details
Experiments 22578841, 11583632, 19217413, 18806873, 27032383, 14609633, 35044719, 16524884
Identification Methods pull down, two hybrid, unspecified method, affinity chromatography technology, phage display
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Rad60-SLD~zf-MIZ
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0016605 - PML body
GO:0016607 - nuclear speck
GO:0016925 - protein sumoylation
and 3 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 651
Hs

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Last updated: 15 Jul 2024