HitPredict

Interactor 1: PIAS2 (O75928)
E3 SUMO-protein ligase PIAS2 (EC 2.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (E3 SUMO-protein transferase PIAS2) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)
Gene: PIAS2

Interactor 2: SUMO2 (P61956)
Small ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3B) (Smt3B)
Gene: SUMO2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.926

Property	Details
Experiments	22578841, 19394292, 32786267, 19217413, 16524884
Identification Methods	pull down, fluorescent resonance energy transfer, two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Rad60-SLD~zf-MIZ
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016605 - PML body GO:0016925 - protein sumoylation GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 621 Hs			1 95
+	Hs
		278250 PIAS2_HUMAN (1-621): 0: 811: 100.00		SUMO3_HUMAN (1-94): 3.76e-41: 132: 96.81
+	Hs
		278256 PIAS2_HUMAN (1-621): 0: 811: 100.00		SUMO1_HUMAN (1-93): 7.76e-35: 116: 45.36
+	Hs
		102147 PIAS2_HUMAN (1-621): 0: 811: 100.00		SUMO5_HUMAN (1-93): 1.8e-34: 115: 44.33
+	Rn
		1140374 PIAS2_RAT (1-550): 0: 749: 97.82		SUMO3_RAT (1-94): 2.04e-42: 135: 95.75
+	Hs
		902827 PIAS3_HUMAN (1-621): 0: 666: 55.25		SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00
+	Hs
		879167 PIAS3_HUMAN (1-621): 0: 666: 55.25		SUMO3_HUMAN (1-94): 3.76e-41: 132: 96.81
+	Hs
		278020 PIAS1_HUMAN (1-621): 0: 653: 54.10		SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00
+	Hs
		278009 PIAS1_HUMAN (1-621): 0: 653: 54.10		SUMO3_HUMAN (1-94): 3.76e-41: 132: 96.81
+	Hs
		928241 PIAS3_HUMAN (1-621): 0: 666: 55.25		SUMO1_HUMAN (1-93): 7.76e-35: 116: 45.36
+	Mm
		222291 PIAS3_MOUSE (1-621): 0: 665: 55.25		SUMO1_MOUSE (1-93): 7.76e-35: 116: 45.36
+	Hs
		278040 PIAS1_HUMAN (1-621): 0: 653: 54.10		SUMO1_HUMAN (1-93): 7.76e-35: 116: 45.36
+	Hs
		102146 PIAS1_HUMAN (1-621): 0: 653: 54.10		SUMO5_HUMAN (1-93): 1.8e-34: 115: 44.33
+	Rn
		78200 B5DFF9_RAT (2-499): 3.5e-175: 508: 43.80		SUMO3_RAT (1-94): 2.04e-42: 135: 95.75
+	Hs
		902668 PIAS4_HUMAN (2-499): 1.7e-172: 502: 43.32		SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00
+	Hs
		879136 PIAS4_HUMAN (2-499): 1.7e-172: 502: 43.32		SUMO3_HUMAN (1-94): 3.76e-41: 132: 96.81
+	Rn
		78199 B5DFF9_RAT (2-499): 3.5e-175: 508: 43.80		SUMO1_RAT (1-93): 7.76e-35: 116: 45.36
+	Hs
		928135 PIAS4_HUMAN (2-499): 1.7e-172: 502: 43.32		SUMO1_HUMAN (1-93): 7.76e-35: 116: 45.36
+	Dm
		332592 Q9XYM5_DROME (10-480): 1.63e-153: 453: 40.99		O97102_DROME (1-94): 1.24e-37: 123: 68.09
+	At
		1147333 SIZ1_ARATH (5-521): 5.9e-109: 349: 21.94		SUMO3_ARATH (1-94): 1.6e-36: 120: 40.43
+	At
		878961 SIZ1_ARATH (5-521): 5.9e-109: 349: 21.94		SUMO1_ARATH (1-91): 8.61e-36: 118: 47.25