HitPredict

Interactor 1: GLRX3 (O76003)
Glutaredoxin-3 (PKC-interacting cousin of thioredoxin) (PICOT) (PKC-theta-interacting protein) (PKCq-interacting protein) (Thioredoxin-like protein 2)
Gene: GLRX3

Interactor 2: GRN (P28799)
Progranulin (PGRN) (Acrogranin) (Epithelin precursor) (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Granulin precursor) (PC cell-derived growth factor) (PCDGF) (Proepithelin) (PEPI) [Cleaved into: Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Epithelin-2) (Granulin B); Granulin-4 (Epithelin-1) (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)]
Gene: GRN

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.728

Property	Details
Experiments	25416956, 25910212, 21516116, 29892012, 31515488
Identification Methods	two hybrid, validated two hybrid, two hybrid array, two hybrid prey pooling approach, two hybrid bait and prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 335 Hs			1 593
+	Hs
		660499 PDIA6_HUMAN (1-251): 7.84e-38: 141: 14.78		GRN_HUMAN (1-593): 0: 726: 100.00
+	Hs
		495471 THIO_HUMAN (13-116): 4.03e-37: 130: 26.92		GRN_HUMAN (1-593): 0: 726: 100.00
+	Mm
		1265750 PDIA6_MOUSE (1-251): 3.55e-38: 142: 14.43		Q9D2V3_MOUSE (1-593): 0: 712: 75.04
+	Mm
		498185 THIO_MOUSE (13-116): 1.63e-37: 131: 26.92		Q9D2V3_MOUSE (1-593): 0: 712: 75.04
+	Hs
		423151 PDIA1_HUMAN (1-113): 3.33e-24: 104: 21.01		GRN_HUMAN (1-593): 0: 726: 100.00
+	Hs
		531730 PDIA4_HUMAN (1-115): 7.77e-24: 104: 19.67		GRN_HUMAN (1-593): 0: 726: 100.00
+	Hs
		660605 DJC10_HUMAN (6-196): 1.69e-18: 88.3: 10.36		GRN_HUMAN (1-593): 0: 726: 100.00
+	Mm
		447646 PDIA1_MOUSE (1-144): 1.48e-23: 102: 18.00		Q9D2V3_MOUSE (1-593): 0: 712: 75.04
+	Mm
		434694 PDIA4_MOUSE (1-125): 6.66e-23: 101: 17.42		Q9D2V3_MOUSE (1-593): 0: 712: 75.04
+	Mm
		1322002 DJC10_MOUSE (6-191): 5.79e-20: 92.9: 11.17		Q9D2V3_MOUSE (1-593): 0: 712: 75.04