Protein: PELI1
E3 ubiquitin-protein ligase pellino homolog 1 (Pellino-1) (EC 2.3.2.27) (Pellino-related intracellular-signaling molecule) (RING-type E3 ubiquitin transferase pellino homolog 1)

Gene: PELI1
Organism: Homo sapiens
Interactions: 69
UniProt ID: Q96FA3

Gene Ontology (top 5):
GO:0001819 - positive regulation of cytokine production
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0008592 - regulation of Toll signaling pathway
GO:0030890 - positive regulation of B cell proliferation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

848448

IRAK1
Interleukin-1 receptor-associated kinase 1

11

10

Small-scale

0.761

High

1291025

IRAK4
Interleukin-1 receptor-associated kinase 4

9

2

Small-scale

0.757

High

1291030

TRAF6
TNF receptor-associated factor 6

4

3

Small-scale

0.694

High

896518

UBE2N
Ubiquitin-conjugating enzyme E2 N

3

4

Small-scale

0.655

High

1033131

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

3

5

Small-scale

0.655

High

169301

MDM4
Protein Mdm4

3

0

Small-scale

0.652

High

1038305

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

2

6

Small-scale

0.634

High

1291027

TBK1
Serine/threonine-protein kinase TBK1

2

1

Small-scale

0.611

High

1291022

P63
Tumor protein 63

2

3

High-throughput

0.606

High

476191

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

2

Small-scale

0.602

High

151621

GOSR2
Golgi SNAP receptor complex member 2

2

0

High-throughput

0.580

High

360267

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

2

0

High-throughput

0.580

High

1077643

PI5PA
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

2

0

High-throughput

0.580

High

236967

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

1

Small-scale

0.578

High

1036808

SQSTM
Sequestosome-1

1

3

Small-scale

0.578

High

1291031

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

2

Small-scale

0.578

High

724561

IRS1
Insulin receptor substrate 1

2

1

High-throughput

0.576

High

942865

SRPK2
SRSF protein kinase 2

1

3

High-throughput

0.569

High

1291019

SRPK1
SRSF protein kinase 1

1

2

High-throughput

0.569

High

338832

EGFR
Epidermal growth factor receptor

1

1

Small-scale

0.561

High

981059

KPCT
Protein kinase C theta type

1

1

Small-scale

0.561

High

781414

BCL6
B-cell lymphoma 6 protein

1

0

Small-scale

0.554

High

1170209

CL17A
C-type lectin domain family 17, member A

2

1

High-throughput

0.553

High

997435

VAC14
Protein VAC14 homolog

1

0

High-throughput

0.549

High

1075957

PCH2
Pachytene checkpoint protein 2 homolog

1

0

High-throughput

0.549

High

1035974

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

Small-scale

0.537

High

206969

SMAD6
Mothers against decapentaplegic homolog 6

1

2

Small-scale

0.529

High

387286

P53
Cellular tumor antigen p53

1

3

Small-scale

0.527

High

930350

UBC9
SUMO-conjugating enzyme UBC9

1

3

Small-scale

0.527

High

1291021

MYD88
Myeloid differentiation primary response protein MyD88

1

2

Small-scale

0.515

High

1271737

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.513

High

158524

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

2

Small-scale

0.501

High

849407

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

4

Small-scale

0.501

High

895877

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

4

Small-scale

0.501

High

919823

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

4

Small-scale

0.501

High

791856

HD
Huntingtin

1

0

High-throughput

0.493

High

1034676

HAP28
28 kDa heat- and acid-stable phosphoprotein

1

0

High-throughput

0.493

High

796481

ZAP70
Tyrosine-protein kinase ZAP-70

1

0

Small-scale

0.480

High

197911

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

11

Small-scale

0.479

High

201396

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

4

Small-scale

0.479

High

263443

DEAF1
Deformed epidermal autoregulatory factor 1 homolog

1

1

Small-scale

0.479

High

697574

HPPD
4-hydroxyphenylpyruvate dioxygenase

1

1

Small-scale

0.479

High

944370

PRKDC
DNA-dependent protein kinase catalytic subunit

1

1

Small-scale

0.479

High

1031582

ATM
Serine-protein kinase ATM

1

1

Small-scale

0.479

High

1039464

IRF5
Interferon regulatory factor 5

1

1

Small-scale

0.479

High

1291020

CTIP
DNA endonuclease RBBP8

1

1

Small-scale

0.479

High

1291028

ASC
Apoptosis-associated speck-like protein containing a CARD

1

1

Small-scale

0.479

High

246261

NBN
Nibrin

1

0

Small-scale

0.458

High

319968

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

Small-scale

0.458

High

455756

PARP1
Poly [ADP-ribose] polymerase 1

1

0

Small-scale

0.458

High

525015

XRCC5
X-ray repair cross-complementing protein 5

1

0

Small-scale

0.458

High

555592

H2AX
Histone H2AX

1

0

Small-scale

0.458

High

579726

XRCC1
DNA repair protein XRCC1

1

0

Small-scale

0.458

High

599711

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

0

Small-scale

0.458

High

837062

MRE11
Double-strand break repair protein MRE11

1

0

Small-scale

0.458

High

862090

DAPK1
Death-associated protein kinase 1

1

0

Small-scale

0.458

High

1019074

TP53B
TP53-binding protein 1

1

0

Small-scale

0.458

High

1216097

TCAM1
TIR domain-containing adapter molecule 1

1

0

Small-scale

0.458

High

1271999

RAD50
DNA repair protein RAD50

1

0

Small-scale

0.458

High

403675

AP2A
Transcription factor AP-2-alpha

1

0

High-throughput

0.438

High

1291024

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

540397

IL1R1
Interleukin-1 receptor type 1

1

1

Small-scale

0.437

High

824274

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

Small-scale

0.437

High

945714

NGAL
Neutrophil gelatinase-associated lipocalin

2

0

High-throughput

0.316

High

1230161

CNTRB
Centrobin

2

0

High-throughput

0.316

High

1291023

RIMS4
Regulating synaptic membrane exocytosis protein 4

2

0

High-throughput

0.316

High

47287

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

1291029

WASC3
WASH complex subunit 3

1

0

High-throughput

0.268

Low

1291026

SAE2
SUMO-activating enzyme subunit 2

1

0

Small-scale

0.261

Low


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Last updated: 15 Jul 2024