HitPredict

Interactor 1: KRT36 (O76013)
Keratin, type I cuticular Ha6 (Hair keratin, type I Ha6) (Keratin-36) (K36)
Gene: KRT36

Interactor 2: K2C8 (P05787)
Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8)
Gene: KRT8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005829 - cytosol GO:0030280 - structural constituent of skin epidermis GO:0045095 - keratin filament GO:0045109 - intermediate filament organization GO:0045111 - intermediate filament cytoskeleton and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 467 Hs			1 483
+	Hs
		444534 K1C17_HUMAN (85-465): 6.17e-149: 433: 56.69		K2C7_HUMAN (1-464): 4.13e-154: 448: 60.34
+	Hs
		359297 K1C14_HUMAN (4-466): 4.36e-147: 429: 49.90		K2C3_HUMAN (63-424): 5.15e-135: 405: 65.95
+	Hs
		359348 K1C14_HUMAN (4-466): 4.36e-147: 429: 49.90		KRT81_HUMAN (12-418): 1.03e-88: 282: 53.07
+	Hs
		213924 K1C14_HUMAN (4-466): 4.36e-147: 429: 49.90		KRT86_HUMAN (12-418): 3.09e-87: 277: 53.32
+	Hs
		980271 K1C17_HUMAN (85-465): 6.17e-149: 433: 56.69		K2C79_HUMAN (8-415): 2.02e-76: 250: 57.39
+	Hs
		359368 K1C14_HUMAN (4-466): 4.36e-147: 429: 49.90		K2C79_HUMAN (8-415): 2.02e-76: 250: 57.39
+	Hs
		318773 K1C13_HUMAN (82-444): 9.39e-143: 418: 53.30		K2C75_HUMAN (2-405): 3.9e-79: 258: 64.04
+	Hs
		980257 K1C17_HUMAN (85-465): 6.17e-149: 433: 56.69		K2C72_HUMAN (10-405): 1.57e-71: 237: 58.33
+	Hs
		359351 K1C14_HUMAN (4-466): 4.36e-147: 429: 49.90		K2C72_HUMAN (10-405): 1.57e-71: 237: 58.33
+	Hs
		821648 K1C17_HUMAN (85-465): 6.17e-149: 433: 56.69		K2C6C_HUMAN (56-405): 2.63e-66: 225: 70.74
+	Hs
		531555 K1C17_HUMAN (85-465): 6.17e-149: 433: 56.69		K2C5_HUMAN (56-405): 9.54e-66: 223: 71.02
+	Hs
		359315 K1C14_HUMAN (4-466): 4.36e-147: 429: 49.90		K2C6C_HUMAN (56-405): 2.63e-66: 225: 70.74
+	Hs
		359482 K1C17_HUMAN (85-465): 6.17e-149: 433: 56.69		K2C6A_HUMAN (56-405): 8.09e-65: 220: 70.74
+	Hs
		359299 K1C14_HUMAN (4-466): 4.36e-147: 429: 49.90		K2C5_HUMAN (56-405): 9.54e-66: 223: 71.02
+	Hs
		409054 K1C17_HUMAN (85-465): 6.17e-149: 433: 56.69		K2C8_HUMAN (1-483): 2.44e-63: 215: 100.00
+	Hs
		359290 K1C14_HUMAN (4-466): 4.36e-147: 429: 49.90		K2C8_HUMAN (1-483): 2.44e-63: 215: 100.00
+	Hs
		380441 K1C13_HUMAN (82-444): 9.39e-143: 418: 53.30		K2C6B_HUMAN (56-405): 2.25e-66: 225: 70.46
+	Hs
		359460 K1C13_HUMAN (82-444): 9.39e-143: 418: 53.30		K2C6A_HUMAN (56-405): 8.09e-65: 220: 70.74
+	Hs
		408990 K1C13_HUMAN (82-444): 9.39e-143: 418: 53.30		K2C8_HUMAN (1-483): 2.44e-63: 215: 100.00
+	Hs
		359330 K1C14_HUMAN (4-466): 4.36e-147: 429: 49.90		KRT85_HUMAN (145-469): 2.62e-09: 61.4: 12.65