Protein: KDM2B
Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B)

Gene: KDM2B
Organism: Homo sapiens
Interactions: 150
UniProt ID: Q8NHM5

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003677 - DNA binding
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

992266

SKP1
S-phase kinase-associated protein 1

13

20

Small-scale

0.981

High

1250624

BCOR
BCL-6 corepressor

8

6

Small-scale

0.970

High

998569

H31
Histone H3.1

4

20

Small-scale

0.893

High

1340152

PCGF1
Polycomb group RING finger protein 1

12

20

Small-scale

0.760

High

1112608

CUL1
Cullin-1

2

20

Small-scale

0.754

High

1325996

RYBP
RING1 and YY1-binding protein

9

4

Small-scale

0.752

High

1340149

RING2
E3 ubiquitin-protein ligase RING2

8

20

Small-scale

0.749

High

1314022

YAF2
YY1-associated factor 2

7

4

High-throughput

0.745

High

591745

H2AX
Histone H2AX

1

7

High-throughput

0.691

High

1204623

BCORL
BCL-6 corepressor-like protein 1

1

4

High-throughput

0.691

High

1258884

H32
Histone H3.2

1

20

High-throughput

0.691

High

1340139

KDM2B
Lysine-specific demethylase 2B

1

6

Small-scale

0.647

High

1055830

RING1
E3 ubiquitin-protein ligase RING1

2

20

High-throughput

0.628

High

370729

FOS
Protein c-Fos

2

4

Small-scale

0.624

High

883619

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.618

High

980940

H2B1C
Histone H2B type 1-C/E/F/G/I

1

6

High-throughput

0.618

High

1017040

H33
Histone H3.3

1

20

High-throughput

0.618

High

1340147

PF21A
PHD finger protein 21A

1

6

High-throughput

0.618

High

338912

CBX6
Chromobox protein homolog 6

2

10

High-throughput

0.611

High

983894

RBX1
E3 ubiquitin-protein ligase RBX1

2

6

Small-scale

0.611

High

1340162

CBX8
Chromobox protein homolog 8

2

10

High-throughput

0.611

High

1087881

NFIA
Nuclear factor 1 A-type

2

16

High-throughput

0.601

High

1133544

NFIX
Nuclear factor 1 X-type

2

16

High-throughput

0.601

High

143129

NFIB
Nuclear factor 1 B-type

2

12

High-throughput

0.584

High

372630

MYC
Myc proto-oncogene protein

2

8

High-throughput

0.584

High

474139

NFIC
Nuclear factor 1 C-type

2

16

High-throughput

0.584

High

872552

SOX2
Transcription factor SOX-2

2

6

Small-scale

0.584

High

1103279

CTBP1
C-terminal-binding protein 1

2

4

High-throughput

0.584

High

1185926

PCGF3
Polycomb group RING finger protein 3

2

20

High-throughput

0.584

High

1340143

CBP
CREB-binding protein

1

12

Small-scale

0.578

High

396556

ESR1
Estrogen receptor

2

18

High-throughput

0.571

High

1340144

KAT5
Histone acetyltransferase KAT5

1

1

Small-scale

0.561

High

1152985

CEBPE
CCAAT/enhancer-binding protein epsilon

1

2

High-throughput

0.541

High

129774

CBX4
E3 SUMO-protein ligase CBX4

1

10

High-throughput

0.536

High

407662

S100B
Protein S100-B

1

3

High-throughput

0.536

High

1340155

RTF2
Replication termination factor 2

1

1

High-throughput

0.536

High

1063455

GOGA2
Golgin subfamily A member 2

2

6

High-throughput

0.533

High

1097439

CBX3
Chromobox protein homolog 3

1

10

High-throughput

0.515

High

1316945

FAM9B
Protein FAM9B

1

0

High-throughput

0.513

High

906712

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

3

Small-scale

0.501

High

1328743

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

12

High-throughput

0.494

High

909110

NEK4
Serine/threonine-protein kinase Nek4

1

5

High-throughput

0.489

High

130551

SPT5H
Transcription elongation factor SPT5

1

8

High-throughput

0.479

High

181539

TBXT
T-box transcription factor T

1

3

High-throughput

0.479

High

191005

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

3

High-throughput

0.479

High

210059

CRX
Cone-rod homeobox protein

1

8

High-throughput

0.479

High

216964

KLF4
Krueppel-like factor 4

1

11

High-throughput

0.479

High

225067

TLX3
T-cell leukemia homeobox protein 3

1

9

High-throughput

0.479

High

226576

TLX2
T-cell leukemia homeobox protein 2

1

4

High-throughput

0.479

High

246782

KDM1A
Lysine-specific histone demethylase 1A

1

1

High-throughput

0.479

High

282755

E2F6
Transcription factor E2F6

1

5

High-throughput

0.479

High

289161

PRDM1
PR domain zinc finger protein 1

1

1

High-throughput

0.479

High

339805

KLF8
Krueppel-like factor 8

1

11

High-throughput

0.479

High

404244

GCR
Glucocorticoid receptor

1

18

High-throughput

0.479

High

414252

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

430149

JUN
Transcription factor Jun

1

2

Small-scale

0.479

High

487548

PARP1
Poly [ADP-ribose] polymerase 1

1

6

High-throughput

0.479

High

517484

GLI2
Zinc finger protein GLI2

1

2

High-throughput

0.479

High

517547

GLI3
Transcriptional activator GLI3

1

2

High-throughput

0.479

High

519404

MYB
Transcriptional activator Myb

1

3

High-throughput

0.479

High

520212

ANDR
Androgen receptor

1

16

High-throughput

0.479

High

540911

ERG
Transcriptional regulator ERG

1

16

High-throughput

0.479

High

543585

ERR1
Steroid hormone receptor ERR1

1

15

Small-scale

0.479

High

577469

ETS1
Protein C-ets-1

1

17

High-throughput

0.479

High

581695

MYOD1
Myoblast determination protein 1

1

4

High-throughput

0.479

High

590459

GATA1
Erythroid transcription factor

1

2

High-throughput

0.479

High

625510

CSK22
Casein kinase II subunit alpha'

1

12

High-throughput

0.479

High

635204

HNF1A
Hepatocyte nuclear factor 1-alpha

1

1

High-throughput

0.479

High

662251

PAX7
Paired box protein Pax-7

1

7

High-throughput

0.479

High

662463

GATA2
Endothelial transcription factor GATA-2

1

2

High-throughput

0.479

High

662614

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

2

High-throughput

0.479

High

685269

PAX6
Paired box protein Pax-6

1

6

High-throughput

0.479

High

703174

TEAD1
Transcriptional enhancer factor TEF-1

1

1

High-throughput

0.479

High

725287

TLX1
T-cell leukemia homeobox protein 1

1

7

High-throughput

0.479

High

765725

BMI1
Polycomb complex protein BMI-1

1

20

High-throughput

0.479

High

766106

PCGF2
Polycomb group RING finger protein 2

1

20

High-throughput

0.479

High

775885

HNF1B
Hepatocyte nuclear factor 1-beta

1

9

High-throughput

0.479

High

776103

SOX5
Transcription factor SOX-5

1

5

High-throughput

0.479

High

776222

SOX6
Transcription factor SOX-6

1

8

High-throughput

0.479

High

789531

PPARG
Peroxisome proliferator-activated receptor gamma

1

17

High-throughput

0.479

High

799992

COIL
Coilin

1

2

High-throughput

0.479

High

832752

BCL6
B-cell lymphoma 6 protein

1

2

Small-scale

0.479

High

833995

HNF4A
Hepatocyte nuclear factor 4-alpha

1

14

High-throughput

0.479

High

837069

ELK3
ETS domain-containing protein Elk-3

1

16

High-throughput

0.479

High

846922

ETV4
ETS translocation variant 4

1

15

High-throughput

0.479

High

862310

YAP1
Transcriptional coactivator YAP1

1

7

High-throughput

0.479

High

873104

SOX9
Transcription factor SOX-9

1

6

High-throughput

0.479

High

877535

LHX1
LIM/homeobox protein Lhx1

1

5

High-throughput

0.479

High

895760

LHX2
LIM/homeobox protein Lhx2

1

5

High-throughput

0.479

High

920127

PLK1
Serine/threonine-protein kinase PLK1

1

2

Small-scale

0.479

High

938483

PAX9
Paired box protein Pax-9

1

6

High-throughput

0.479

High

942452

GSC
Homeobox protein goosecoid

1

5

High-throughput

0.479

High

944706

KLF3
Krueppel-like factor 3

1

11

High-throughput

0.479

High

980018

H4
Histone H4

1

5

High-throughput

0.479

High

1006863

PHC1
Polyhomeotic-like protein 1

1

5

High-throughput

0.479

High

1033732

PO5F1
POU domain, class 5, transcription factor 1

1

5

High-throughput

0.479

High

1040066

PAX2
Paired box protein Pax-2

1

6

High-throughput

0.479

High

1045545

TF65
Transcription factor p65

1

9

High-throughput

0.479

High

1052894

HME1
Homeobox protein engrailed-1

1

2

High-throughput

0.479

High

1056629

PAX8
Paired box protein Pax-8

1

7

High-throughput

0.479

High

1091233

FOXI1
Forkhead box protein I1

1

5

High-throughput

0.479

High

1091320

FOXL1
Forkhead box protein L1

1

5

High-throughput

0.479

High

1118739

KLF5
Krueppel-like factor 5

1

11

High-throughput

0.479

High

1132219

CBX2
Chromobox protein homolog 2

1

10

High-throughput

0.479

High

1145825

IRF4
Interferon regulatory factor 4

1

1

High-throughput

0.479

High

1155562

EZH2
Histone-lysine N-methyltransferase EZH2

1

6

Small-scale

0.479

High

1160872

TBR1
T-box brain protein 1

1

3

High-throughput

0.479

High

1178670

ISX
Intestine-specific homeobox

1

6

High-throughput

0.479

High

1217746

GFI1B
Zinc finger protein Gfi-1b

1

3

Small-scale

0.479

High

1219304

ECM29
Proteasome adapter and scaffold protein ECM29

1

4

Small-scale

0.479

High

1276510

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

1286249

PCGF5
Polycomb group RING finger protein 5

1

20

High-throughput

0.479

High

1310093

MGAP
MAX gene-associated protein

1

3

High-throughput

0.479

High

1312465

PHC2
Polyhomeotic-like protein 2

1

5

High-throughput

0.479

High

1336921

PHC3
Polyhomeotic-like protein 3

1

9

High-throughput

0.479

High

1340140

SP7
Transcription factor Sp7

1

9

High-throughput

0.479

High

1340142

ESR2
Estrogen receptor beta

1

17

High-throughput

0.479

High

1340145

LHX4
LIM/homeobox protein Lhx4

1

5

High-throughput

0.479

High

1340146

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

1

High-throughput

0.479

High

1340150

FEV
Protein FEV

1

15

High-throughput

0.479

High

1340151

ELF4
ETS-related transcription factor Elf-4

1

17

High-throughput

0.479

High

1340153

SOX7
Transcription factor SOX-7

1

6

High-throughput

0.479

High

1340154

KLF16
Krueppel-like factor 16

1

9

High-throughput

0.479

High

1340156

PCGF6
Polycomb group RING finger protein 6

1

20

High-throughput

0.479

High

1340157

FOXQ1
Forkhead box protein Q1

1

6

High-throughput

0.479

High

1340158

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

3

High-throughput

0.479

High

1340159

SOX17
Transcription factor SOX-17

1

6

High-throughput

0.479

High

1340160

NANOG
Homeobox protein NANOG

1

7

High-throughput

0.479

High

1340166

VSX1
Visual system homeobox 1

1

8

High-throughput

0.479

High

1340167

LHX3
LIM/homeobox protein Lhx3

1

5

High-throughput

0.479

High

1340168

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1340169

XPO7
Exportin-7

1

5

High-throughput

0.479

High

1340170

KLF15
Krueppel-like factor 15

1

11

High-throughput

0.479

High

1340171

RCOR1
REST corepressor 1

1

3

High-throughput

0.479

High

1340172

LHX6
LIM/homeobox protein Lhx6

1

5

High-throughput

0.479

High

1340173

ZN330
Zinc finger protein 330

1

3

High-throughput

0.479

High

1340174

KLF12
Krueppel-like factor 12

1

12

High-throughput

0.479

High

1340175

ETV7
Transcription factor ETV7

1

16

High-throughput

0.479

High

538441

EGR2
E3 SUMO-protein ligase EGR2

1

0

High-throughput

0.458

High

1026470

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

1109912

HDAC1
Histone deacetylase 1

1

0

High-throughput

0.458

High

1157322

SSX1
Protein SSX1

1

0

Small-scale

0.458

High

1340141

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.458

High

1340148

SIN3A
Paired amphipathic helix protein Sin3a

1

0

Small-scale

0.458

High

1340163

GCM1
Chorion-specific transcription factor GCMa

1

0

High-throughput

0.458

High

1340165

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1340164

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

5

High-throughput

0.437

High

1025934

NDP
Norrin

1

0

Small-scale

0.249

Low

1340161

FBRS
Probable fibrosin-1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025