Protein: PHF8
Histone lysine demethylase PHF8 (EC 1.14.11.27) (EC 1.14.11.65) (PHD finger protein 8) ([histone H3]-dimethyl-L-lysine(36) demethylase PHF8) ([histone H3]-dimethyl-L-lysine(9) demethylase PHF8)

Gene: PHF8
Organism: Homo sapiens
Interactions: 184
UniProt ID: Q9UPP1

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0003682 - chromatin binding
GO:0003712 - transcription coregulator activity
GO:0005506 - iron ion binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

998947

H31
Histone H3.1

8

20

Small-scale

0.975

High

1162080

H31T
Histone H3.1t

3

20

Small-scale

0.820

High

1163291

H2B2E
Histone H2B type 2-E

2

17

High-throughput

0.811

High

74645

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

2

High-throughput

0.691

High

175950

SET1A
Histone-lysine N-methyltransferase SETD1A

1

16

Small-scale

0.691

High

277852

H2AY
Core histone macro-H2A.1

1

10

High-throughput

0.691

High

848839

MAGAA
Melanoma-associated antigen 10

4

1

High-throughput

0.691

High

629176

CCNA2
Cyclin-A2

5

0

Small-scale

0.682

High

1260553

NOL8
Nucleolar protein 8

1

0

High-throughput

0.656

High

1371780

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

3

Small-scale

0.646

High

1364305

TOPB1
DNA topoisomerase 2-binding protein 1

2

2

Small-scale

0.639

High

174642

TRI66
Tripartite motif-containing protein 66

1

6

High-throughput

0.618

High

260617

BRD4
Bromodomain-containing protein 4

1

15

High-throughput

0.618

High

639850

TAF1
Transcription initiation factor TFIID subunit 1

1

11

Small-scale

0.618

High

883733

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.618

High

1017303

H33
Histone H3.3

1

20

High-throughput

0.618

High

1141365

BRD3
Bromodomain-containing protein 3

1

17

High-throughput

0.618

High

1194456

LARP7
La-related protein 7

1

3

High-throughput

0.618

High

1239490

H3C
Histone H3.3C

1

20

High-throughput

0.618

High

1418644

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

2

High-throughput

0.618

High

1446440

BRD7
Bromodomain-containing protein 7

1

11

High-throughput

0.618

High

1461510

BRPF3
Bromodomain and PHD finger-containing protein 3

1

3

High-throughput

0.618

High

1462515

ZN711
Zinc finger protein 711

2

0

Small-scale

0.612

High

668073

CDK2
Cyclin-dependent kinase 2

2

3

Small-scale

0.611

High

1086939

CDC20
Cell division cycle protein 20 homolog

2

8

Small-scale

0.611

High

423464

A4
Amyloid-beta precursor protein

2

1

High-throughput

0.602

High

520647

RARA
Retinoic acid receptor alpha

2

17

Small-scale

0.602

High

1211287

SNPC4
snRNA-activating protein complex subunit 4

2

5

High-throughput

0.601

High

980547

H4
Histone H4

2

8

Small-scale

0.595

High

1461906

FZR1
Fizzy-related protein homolog

2

9

Small-scale

0.584

High

1136762

MD2BP
MAD2L1-binding protein

2

0

High-throughput

0.576

High

1448907

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

2

0

High-throughput

0.576

High

272848

PHF2
Lysine-specific demethylase PHF2

1

11

High-throughput

0.575

High

667512

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

5

Small-scale

0.561

High

272552

OBSL1
Obscurin-like protein 1

2

3

High-throughput

0.558

High

857596

NOTC1
Neurogenic locus notch homolog protein 1

1

1

High-throughput

0.554

High

905514

HCFC1
Host cell factor 1

1

8

Small-scale

0.554

High

1054821

SUH
Recombining binding protein suppressor of hairless

1

2

High-throughput

0.554

High

130657

SPT5H
Transcription elongation factor SPT5

1

8

High-throughput

0.536

High

275926

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

1

2

High-throughput

0.536

High

407731

S100B
Protein S100-B

1

1

High-throughput

0.536

High

443560

CDK1
Cyclin-dependent kinase 1

1

4

High-throughput

0.536

High

948613

APC15
Anaphase-promoting complex subunit 15

1

1

High-throughput

0.536

High

1027852

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

7

High-throughput

0.536

High

1029174

E2F1
Transcription factor E2F1

1

2

Small-scale

0.536

High

1089286

TRI26
Tripartite motif-containing protein 26

1

1

High-throughput

0.536

High

1099825

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

3

High-throughput

0.536

High

1120990

TRI29
Tripartite motif-containing protein 29

1

1

High-throughput

0.536

High

1129396

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

12

High-throughput

0.536

High

1143713

Q15156
Protein PML

1

16

Small-scale

0.536

High

1158205

MK14
Mitogen-activated protein kinase 14

1

6

High-throughput

0.536

High

1217226

RIF1
Telomere-associated protein RIF1

1

3

High-throughput

0.536

High

1357998

RN138
E3 ubiquitin-protein ligase RNF138

1

9

High-throughput

0.536

High

1365160

MAML1
Mastermind-like protein 1

1

3

High-throughput

0.536

High

1447223

INCE
Inner centromere protein

1

2

High-throughput

0.536

High

1460502

SPB13
Serpin B13

1

2

High-throughput

0.536

High

1462513

FBW1A
F-box/WD repeat-containing protein 1A

1

6

High-throughput

0.536

High

522018

H14
Histone H1.4

1

2

High-throughput

0.515

High

595646

H15
Histone H1.5

1

3

High-throughput

0.515

High

1400995

ARX
Homeobox protein ARX

1

5

Small-scale

0.515

High

370374

CYTA
Cystatin-A

1

0

High-throughput

0.513

High

423716

ARGI1
Arginase-1

1

0

High-throughput

0.513

High

451593

CENPB
Major centromere autoantigen B

1

0

High-throughput

0.513

High

671873

ZA2G
Zinc-alpha-2-glycoprotein

1

0

High-throughput

0.513

High

729630

CASPE
Caspase-14

1

0

High-throughput

0.513

High

878289

DPOD2
DNA polymerase delta subunit 2

1

0

High-throughput

0.513

High

941304

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.513

High

956697

CKS1
Cyclin-dependent kinases regulatory subunit 1

1

0

High-throughput

0.513

High

1012377

RT15
Small ribosomal subunit protein uS15m

1

0

High-throughput

0.513

High

1032885

XPC
DNA repair protein complementing XP-C cells

1

0

High-throughput

0.513

High

1118008

PKP1
Plakophilin-1

1

0

High-throughput

0.513

High

1208824

TDIF2
Deoxynucleotidyltransferase terminal-interacting protein 2

1

0

High-throughput

0.513

High

1245233

BRAT1
Integrator complex assembly factor BRAT1

1

0

High-throughput

0.513

High

1330979

CGAS
Cyclic GMP-AMP synthase

1

0

High-throughput

0.513

High

1364424

RT27
Small ribosomal subunit protein mS27

1

0

High-throughput

0.513

High

1385986

ZN653
Zinc finger protein 653

1

0

High-throughput

0.513

High

1389092

THA11
THAP domain-containing protein 11

1

0

High-throughput

0.513

High

1431130

REN3A
Regulator of nonsense transcripts 3A

1

0

High-throughput

0.513

High

1453256

IL37
Interleukin-37

1

0

High-throughput

0.513

High

1454301

RCC2
Protein RCC2

1

0

High-throughput

0.513

High

1460230

CBPA4
Carboxypeptidase A4

1

0

High-throughput

0.513

High

1462512

NIP7
60S ribosome subunit biogenesis protein NIP7 homolog

1

0

High-throughput

0.513

High

964513

SUMO2
Small ubiquitin-related modifier 2

1

4

High-throughput

0.501

High

339897

KLF8
Krueppel-like factor 8

1

11

High-throughput

0.500

High

426598

HMGN2
Non-histone chromosomal protein HMG-17

1

0

High-throughput

0.493

High

289292

SPB7
Serpin B7

1

3

High-throughput

0.489

High

424566

PAI2
Plasminogen activator inhibitor 2

1

2

High-throughput

0.489

High

457935

INVO
Involucrin

1

1

High-throughput

0.489

High

892147

KLK7
Kallikrein-7

1

1

High-throughput

0.489

High

1143305

PLEC
Plectin

1

1

High-throughput

0.489

High

1187936

KR197
Keratin-associated protein 19-7

1

1

High-throughput

0.489

High

1200027

KLH26
Kelch-like protein 26

1

2

High-throughput

0.489

High

1308612

NUDC3
NudC domain-containing protein 3

1

1

High-throughput

0.489

High

1309634

SPA12
Serpin A12

1

3

High-throughput

0.489

High

1369025

EVPL
Envoplakin

1

1

High-throughput

0.489

High

1413684

P4K2A
Phosphatidylinositol 4-kinase type 2-alpha

1

1

High-throughput

0.489

High

129559

MEN1
Menin

1

4

High-throughput

0.479

High

132380

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

6

High-throughput

0.479

High

141170

NOP56
Nucleolar protein 56

1

1

High-throughput

0.479

High

143331

NFIB
Nuclear factor 1 B-type

1

15

High-throughput

0.479

High

186123

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

3

Small-scale

0.479

High

191161

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

4

High-throughput

0.479

High

254450

CC14B
Dual specificity protein phosphatase CDC14B

1

3

High-throughput

0.479

High

302669

RNF8
E3 ubiquitin-protein ligase RNF8

1

5

Small-scale

0.479

High

334126

SMC2
Structural maintenance of chromosomes protein 2

1

3

Small-scale

0.479

High

373506

MYC
Myc proto-oncogene protein

1

8

High-throughput

0.479

High

463843

LYN
Tyrosine-protein kinase Lyn

1

2

High-throughput

0.479

High

474378

NFIC
Nuclear factor 1 C-type

1

19

High-throughput

0.479

High

487888

PARP1
Poly [ADP-ribose] polymerase 1

1

12

High-throughput

0.479

High

519437

MYB
Transcriptional activator Myb

1

5

High-throughput

0.479

High

538128

HSP7C
Heat shock cognate 71 kDa protein

1

1

Small-scale

0.479

High

621797

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

Small-scale

0.479

High

667020

CCNE1
G1/S-specific cyclin-E1

1

1

Small-scale

0.479

High

697294

APEX1
DNA repair nuclease/redox regulator APEX1

1

3

High-throughput

0.479

High

704998

RBL1
Retinoblastoma-like protein 1

1

1

Small-scale

0.479

High

718664

CDC27
Cell division cycle protein 27 homolog

1

6

Small-scale

0.479

High

800172

COIL
Coilin

1

2

High-throughput

0.479

High

837108

ELK3
ETS domain-containing protein Elk-3

1

17

High-throughput

0.479

High

862555

YAP1
Transcriptional coactivator YAP1

1

13

High-throughput

0.479

High

926435

BLM
RecQ-like DNA helicase BLM

1

3

Small-scale

0.479

High

954312

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.479

High

965334

WDR5
WD repeat-containing protein 5

1

9

Small-scale

0.479

High

982878

RS24
Small ribosomal subunit protein eS24

1

1

High-throughput

0.479

High

985073

RL31
Large ribosomal subunit protein eL31

1

2

High-throughput

0.479

High

988829

RAC1
Ras-related C3 botulinum toxin substrate 1

1

5

High-throughput

0.479

High

995351

CSK2B
Casein kinase II subunit beta

1

4

High-throughput

0.479

High

1045914

TF65
Transcription factor p65

1

5

High-throughput

0.479

High

1088104

NFIA
Nuclear factor 1 A-type

1

19

High-throughput

0.479

High

1093090

CDC16
Cell division cycle protein 16 homolog

1

6

Small-scale

0.479

High

1114667

CUL3
Cullin-3

1

5

High-throughput

0.479

High

1118698

KLF9
Krueppel-like factor 9

1

9

High-throughput

0.479

High

1133740

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

1152761

ELF2
ETS-related transcription factor Elf-2

1

15

High-throughput

0.479

High

1220892

RN123
E3 ubiquitin-protein ligase RNF123

1

7

High-throughput

0.479

High

1276974

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.479

High

1314486

SLX4
Structure-specific endonuclease subunit SLX4

1

5

High-throughput

0.479

High

1339039

NUP43
Nucleoporin Nup43

1

16

High-throughput

0.479

High

1367600

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1387646

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

7

High-throughput

0.479

High

1400051

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

6

Small-scale

0.479

High

1414619

DDX23
Probable ATP-dependent RNA helicase DDX23

1

2

High-throughput

0.479

High

1428674

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

3

High-throughput

0.479

High

1458471

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

11

Small-scale

0.479

High

1459327

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1460730

CDC23
Cell division cycle protein 23 homolog

1

6

Small-scale

0.479

High

1460751

APC7
Anaphase-promoting complex subunit 7

1

6

Small-scale

0.479

High

1460780

ANC2
Anaphase-promoting complex subunit 2

1

6

Small-scale

0.479

High

1462514

ZN330
Zinc finger protein 330

1

3

High-throughput

0.479

High

1462516

LSM4
U6 snRNA-associated Sm-like protein LSm4

1

1

High-throughput

0.479

High

171943

ZN263
Zinc finger protein 263

1

0

Small-scale

0.458

High

279539

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

719187

MPIP1
M-phase inducer phosphatase 1

1

0

Small-scale

0.458

High

766943

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

1340926

CDC26
Anaphase-promoting complex subunit CDC26

1

0

Small-scale

0.458

High

1393828

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1416245

RPAP1
RNA polymerase II-associated protein 1

1

0

High-throughput

0.458

High

1430918

APC1
Anaphase-promoting complex subunit 1

1

0

Small-scale

0.458

High

1435460

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1460761

APC5
Anaphase-promoting complex subunit 5

1

0

Small-scale

0.458

High

1460771

APC4
Anaphase-promoting complex subunit 4

1

0

Small-scale

0.458

High

766012

BMI1
Polycomb complex protein BMI-1

1

20

High-throughput

0.445

High

998111

CSK21
Casein kinase II subunit alpha

1

12

High-throughput

0.445

High

1291607

HOOK3
Protein Hook homolog 3

1

4

High-throughput

0.437

High

1311891

DHX40
Probable ATP-dependent RNA helicase DHX40

1

5

High-throughput

0.437

High

1434245

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

1461698

HECD1
E3 ubiquitin-protein ligase HECTD1

1

11

High-throughput

0.437

High

1451315

PIHD1
PIH1 domain-containing protein 1

1

0

Small-scale

0.426

High

1461791

FZD10
Frizzled-10

1

0

High-throughput

0.426

High

528728

PPGB
Lysosomal protective protein

2

0

High-throughput

0.313

High

593716

BGAL
Beta-galactosidase

2

0

High-throughput

0.313

High

1030342

AMPD2
AMP deaminase 2

2

0

High-throughput

0.313

High

417852

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.279

Low

505209

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

0

High-throughput

0.279

Low

813260

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.279

Low

1011746

RT35
Small ribosomal subunit protein mS35

1

0

High-throughput

0.279

Low

1062317

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

0

High-throughput

0.279

Low

1154358

CYTM
Cystatin-M

1

0

High-throughput

0.279

Low

1242374

PLBL1
Phospholipase B-like 1

1

0

High-throughput

0.279

Low

1248754

SBSN
Suprabasin

1

0

High-throughput

0.279

Low

1416481

LS14B
Protein LSM14 homolog B

1

0

High-throughput

0.279

Low

1462517

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.279

Low

519267

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.249

Low

1340207

ARK74
Aflatoxin B1 aldehyde reductase member 4

1

0

High-throughput

0.232

Low

1395552

S45A3
Solute carrier family 45 member 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025