Protein: KDM2A
Lysine-specific demethylase 2A (EC 1.14.11.27) (CXXC-type zinc finger protein 8) (F-box and leucine-rich repeat protein 11) (F-box protein FBL7) (F-box protein Lilina) (F-box/LRR-repeat protein 11) (JmjC domain-containing histone demethylation protein 1A) ([Histone-H3]-lysine-36 demethylase 1A)

Gene: KDM2A
Organism: Homo sapiens
Interactions: 83
UniProt ID: Q9Y2K7

Gene Ontology (top 5):
GO:0003712 - transcription coregulator activity
GO:0005654 - nucleoplasm
GO:0005694 - chromosome
GO:0006303 - double-strand break repair via nonhomologous end joining
GO:0006338 - chromatin remodeling

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

992400

SKP1
S-phase kinase-associated protein 1

8

20

Small-scale

0.966

High

981187

H2B1C
Histone H2B type 1-C/E/F/G/I

2

11

High-throughput

0.754

High

998967

H31
Histone H3.1

2

20

High-throughput

0.754

High

1163306

H2B2E
Histone H2B type 2-E

1

11

High-throughput

0.691

High

1099829

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

3

2

High-throughput

0.662

High

1162088

H31T
Histone H3.1t

1

20

Small-scale

0.647

High

1258987

H32
Histone H3.2

1

20

Small-scale

0.647

High

277855

H2AY
Core histone macro-H2A.1

1

6

High-throughput

0.618

High

355622

NSD2
Histone-lysine N-methyltransferase NSD2

1

7

Small-scale

0.618

High

591896

H2AX
Histone H2AX

1

6

High-throughput

0.618

High

883738

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.618

High

1017315

H33
Histone H3.3

1

20

High-throughput

0.618

High

1114700

CUL3
Cullin-3

1

20

High-throughput

0.618

High

1399979

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

10

Small-scale

0.618

High

980570

H4
Histone H4

2

5

High-throughput

0.611

High

1145566

RBBP5
Retinoblastoma-binding protein 5

2

11

High-throughput

0.611

High

1400628

KI20B
Kinesin-like protein KIF20B

2

5

Small-scale

0.611

High

1368534

CBP
CREB-binding protein

2

13

Small-scale

0.586

High

373546

MYC
Myc proto-oncogene protein

2

9

High-throughput

0.584

High

1045935

TF65
Transcription factor p65

1

8

Small-scale

0.578

High

1067859

EP300
Histone acetyltransferase p300

1

13

Small-scale

0.578

High

442835

RB
Retinoblastoma-associated protein

1

3

Small-scale

0.561

High

1029177

E2F1
Transcription factor E2F1

1

9

Small-scale

0.561

High

370819

FOS
Protein c-Fos

1

5

High-throughput

0.541

High

129832

CBX4
E3 SUMO-protein ligase CBX4

1

13

High-throughput

0.536

High

832844

BCL6
B-cell lymphoma 6 protein

1

3

Small-scale

0.536

High

965348

WDR5
WD repeat-containing protein 5

1

8

High-throughput

0.536

High

1014235

CBX1
Chromobox protein homolog 1

1

13

High-throughput

0.536

High

1054823

SUH
Recombining binding protein suppressor of hairless

1

2

High-throughput

0.536

High

1399381

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

1

High-throughput

0.536

High

1412839

PCGF1
Polycomb group RING finger protein 1

1

20

High-throughput

0.536

High

1420487

DPY30
Protein dpy-30 homolog

1

1

High-throughput

0.536

High

1458474

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

5

High-throughput

0.536

High

1380693

FBX32
F-box only protein 32

1

0

High-throughput

0.518

High

986287

RL8
Large ribosomal subunit protein uL2

1

0

High-throughput

0.513

High

1116626

FHL3
Four and a half LIM domains protein 3

1

0

High-throughput

0.513

High

1330477

HORM2
HORMA domain-containing protein 2

1

0

High-throughput

0.513

High

1363657

H1X
Histone H1.10

1

0

High-throughput

0.513

High

177732

SMAD7
Mothers against decapentaplegic homolog 7

1

3

High-throughput

0.508

High

1014667

SMAD3
Mothers against decapentaplegic homolog 3

1

3

High-throughput

0.508

High

1396154

Z512B
Zinc finger protein 512B

1

4

High-throughput

0.508

High

952484

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

8

High-throughput

0.494

High

596434

H12
Histone H1.2

1

5

High-throughput

0.489

High

901111

RAB5C
Ras-related protein Rab-5C

1

1

High-throughput

0.489

High

976040

RL7A
Large ribosomal subunit protein eL8

1

1

High-throughput

0.489

High

1417738

RTF2
Replication termination factor 2

1

1

High-throughput

0.489

High

129571

MEN1
Menin

1

3

High-throughput

0.479

High

158010

CTRO
Citron Rho-interacting kinase

1

9

High-throughput

0.479

High

191166

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

5

High-throughput

0.479

High

260631

BRD4
Bromodomain-containing protein 4

1

11

High-throughput

0.479

High

285530

EED
Polycomb protein EED

1

9

High-throughput

0.479

High

386378

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

1

High-throughput

0.479

High

397266

ESR1
Estrogen receptor

1

20

Small-scale

0.479

High

487898

PARP1
Poly [ADP-ribose] polymerase 1

1

7

High-throughput

0.479

High

664835

CCND1
G1/S-specific cyclin-D1

1

12

Small-scale

0.479

High

861849

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

13

Small-scale

0.479

High

862571

YAP1
Transcriptional coactivator YAP1

1

16

High-throughput

0.479

High

928369

ATN1
Atrophin-1

1

6

Small-scale

0.479

High

1089071

TP53B
TP53-binding protein 1

1

1

Small-scale

0.479

High

1095855

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

4

High-throughput

0.479

High

1097640

CBX3
Chromobox protein homolog 3

1

13

High-throughput

0.479

High

1102300

ATM
Serine-protein kinase ATM

1

4

Small-scale

0.479

High

1217780

GFI1B
Zinc finger protein Gfi-1b

1

4

Small-scale

0.479

High

1219378

ECM29
Proteasome adapter and scaffold protein ECM29

1

4

Small-scale

0.479

High

1256170

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

1281644

SLN11
Schlafen family member 11

1

1

High-throughput

0.479

High

1339049

NUP43
Nucleoporin Nup43

1

17

High-throughput

0.479

High

1367633

ESR2
Estrogen receptor beta

1

19

High-throughput

0.479

High

1387651

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

9

High-throughput

0.479

High

1460389

KLF15
Krueppel-like factor 15

1

15

High-throughput

0.479

High

1490808

ZN330
Zinc finger protein 330

1

4

High-throughput

0.479

High

248153

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

711682

3MG
DNA-3-methyladenine glycosylase

1

0

Small-scale

0.458

High

1050577

UBE3A
Ubiquitin-protein ligase E3A

1

12

High-throughput

0.445

High

346526

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.437

High

986826

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

High-throughput

0.437

High

1238074

CGB2
Choriogonadotropin subunit beta variant 2

2

0

High-throughput

0.288

High

446094

ENOA
Alpha-enolase

1

0

High-throughput

0.282

High

428555

RLA2
Large ribosomal subunit protein P2

1

0

High-throughput

0.279

Low

1027241

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.279

Low

1126790

BECN1
Beclin-1

1

0

Small-scale

0.249

Low

1213485

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.249

Low

1092687

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025